Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Mathieu Le, Gars"'
Autor:
Craig A. Magaret, Li Li, Allan C. deCamp, Morgane Rolland, Michal Juraska, Brian D. Williamson, James Ludwig, Cindy Molitor, David Benkeser, Alex Luedtke, Brian Simpkins, Fei Heng, Yanqing Sun, Lindsay N. Carpp, Hongjun Bai, Bethany L. Dearlove, Elena E. Giorgi, Mandy Jongeneelen, Boerries Brandenburg, Matthew McCallum, John E. Bowen, David Veesler, Jerald Sadoff, Glenda E. Gray, Sanne Roels, An Vandebosch, Daniel J. Stieh, Mathieu Le Gars, Johan Vingerhoets, Beatriz Grinsztejn, Paul A. Goepfert, Leonardo Paiva de Sousa, Mayara Secco Torres Silva, Martin Casapia, Marcelo H. Losso, Susan J. Little, Aditya Gaur, Linda-Gail Bekker, Nigel Garrett, Carla Truyers, Ilse Van Dromme, Edith Swann, Mary A. Marovich, Dean Follmann, Kathleen M. Neuzil, Lawrence Corey, Alexander L. Greninger, Pavitra Roychoudhury, Ollivier Hyrien, Peter B. Gilbert
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract In the ENSEMBLE randomized, placebo-controlled phase 3 trial (NCT04505722), estimated single-dose Ad26.COV2.S vaccine efficacy (VE) was 56% against moderate to severe–critical COVID-19. SARS-CoV-2 Spike sequences were determined from 484 v
Externí odkaz:
https://doaj.org/article/ae82624b40e944a5925f8f3c70ded9b7
Autor:
Veronica V. Rezelj, Fred Paddenburg, Marie Enajite Diegbe, Julius Nangosyah, Emil C. Reisinger, Weihong Hu, Carla Truyers, Gert Scheper, Mathieu Le Gars, Jenny Hendriks, Frank Struyf, Macaya Douoguih, Hanneke Schuitemaker, Javier Ruiz-Guiñazú
Publikováno v:
Vaccines, Vol 12, Iss 10, p 1136 (2024)
Background: This study aimed to support the end-of-shelf life specification (2.5 × 1010 virus particles [vp]) for the standard Ad26.COV2.S dose (5 × 1010 vp). Methods: This randomized, double-blind Phase 3 study evaluated immunogenicity, reactogeni
Externí odkaz:
https://doaj.org/article/54705ff51339487aa084bce5e1e25b60
Autor:
Catherine Jacob-Dolan, Michelle Lifton, Olivia C. Powers, Jessica Miller, Nicole P. Hachmann, Mya Vu, Nehalee Surve, Camille R. Mazurek, Jana L. Fisher, Stefanie Rodrigues, Robert C. Patio, Trisha Anand, Mathieu Le Gars, Jerald Sadoff, Aaron G. Schmidt, Dan H. Barouch
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109716- (2024)
Summary: The viral vector-based COVID-19 vaccine Ad26.COV2.S has been recommended by the WHO since 2021 and has been administered to over 200 million people. Prior studies have shown that Ad26.COV2.S induces durable neutralizing antibodies (NAbs) tha
Externí odkaz:
https://doaj.org/article/319b65fba338482abc0eb9e090cc8de1
Autor:
Anna Dari, Philippe Jacqmin, Yuki Iwaki, Martine Neyens, Mathieu Le Gars, Jerald Sadoff, Karin Hardt, Javier Ruiz‐Guiñazú, Juan José Pérez‐Ruixo
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 10, Pp 1485-1498 (2023)
Abstract Mechanistic model‐based simulations can be deployed to project the persistence of humoral immune response following vaccination. We used this approach to project the antibody persistence through 24 months from the data pooled across five c
Externí odkaz:
https://doaj.org/article/e5c516261c6749c5aae3b158bce0490e
Autor:
Julie Van Coillie, Tamas Pongracz, Tonći Šuštić, Wenjun Wang, Jan Nouta, Mathieu Le Gars, Sofie Keijzer, Federica Linty, Olvi Cristianawati, Jim B.D. Keijser, Remco Visser, Lonneke A. van Vught, Marleen A. Slim, Niels van Mourik, Merel J. Smit, Adam Sander, David E. Schmidt, Maurice Steenhuis, Theo Rispens, Morten A. Nielsen, Benjamin G. Mordmüller, Alexander P.J. Vlaar, C. Ellen van der Schoot, Ramon Roozendaal, Manfred Wuhrer, Gestur Vidarsson, Brent Appelman, Diederik van de Beek, Marije K. Bomers, Justin de Brabander, Matthijs C. Brouwer, David T.P. Buis, Nora Chekrouni, Marit J. van Gils, Menno D. de Jong, Ayesha H.A. Lavell, Sabine E. Olie, Edgar J.G. Peters, Tom D.Y. Reijnders, Michiel Schinkel, Alex R. Schuurman, Jonne J. Sikkens, Yvo M. Smulders, Joost W. Wiersinga, Antinori Spinello, Cinzia Bassoli, Giovanna Bestetti, Mario Corbellino, Alice Covizzi, Angelica Lupo, Laura Milazzo, Marco Schiuma, Alessandro Torre, Willem A. de Jongh, Ali Salanti, Thor G. Theander, Matthew B.B. McCall, Meral Esen
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107619- (2023)
Summary: IgG antibodies are important mediators of vaccine-induced immunity through complement- and Fc receptor-dependent effector functions. Both are influenced by the composition of the conserved N-linked glycan located in the IgG Fc domain. Here,
Externí odkaz:
https://doaj.org/article/1f6bd129608a46e19f6f87262c09f1b9
Autor:
Lisa H. Tostanoski, Abishek Chandrashekar, Shivani Patel, Jingyou Yu, Catherine Jacob-Dolan, Aiquan Chang, Olivia C. Powers, Daniel Sellers, Sarah Gardner, Julia Barrett, Owen Sanborn, Kathryn E. Stephenson, Jessica L. Ansel, Kate Jaegle, Michael S. Seaman, Maciel Porto, Megan Lok, Brittany Spence, Kathleen Cayer, Danielle Nase, Shaikim Holman, Heath Bradette, Swagata Kar, Hanne Andersen, Mark G. Lewis, Freek Cox, Jeroen T. B. M. Tolboom, Anne Marit de Groot, Dirk Heerwegh, Mathieu Le Gars, Jerald Sadoff, Frank Wegmann, Roland C. Zahn, Hanneke Schuitemaker, Dan H. Barouch
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-6 (2022)
Abstract SARS-CoV-2 Spike-specific binding and neutralizing antibodies, elicited either by natural infection or vaccination, have emerged as potential correlates of protection. An important question, however, is whether vaccine-elicited antibodies in
Externí odkaz:
https://doaj.org/article/2a0525ec444a4d9db1584cc060807b28
Autor:
Ramon Roozendaal, Laura Solforosi, Daniel J. Stieh, Jan Serroyen, Roel Straetemans, Anna Dari, Muriel Boulton, Frank Wegmann, Sietske K. Rosendahl Huber, Joan E. M. van der Lubbe, Jenny Hendriks, Mathieu Le Gars, Liesbeth Dekking, Dominika N. Czapska-Casey, Nuria Guimera, Sarah Janssen, Sarah Tete, Abishek Chandrashekar, Noe B. Mercado, Jingyou Yu, Wouter Koudstaal, Juan J. Perez-Ruixo, Jerry Sadoff, Dan H. Barouch, Hanneke Schuitemaker, Roland Zahn
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Several COVID-19 vaccines have received emergency approval, but durability of protection is unclear. Here, the authors describe correlates of protection (CoP) for the Ad26.COV2.S vaccine in rhesus macaques and report that CoP predict the protection o
Externí odkaz:
https://doaj.org/article/c77c130d228d404b88e0e8b1e5e20f78
Autor:
Anna Lisa Ong-Lim, Georgi Shukarev, Mitzi Trinidad-Aseron, Delia Caparas-Yu, Astrid Greijer, Michel Duchene, Gert Scheper, Vitalija van Paassen, Mathieu Le Gars, Conor P. Cahill, Hanneke Schuitemaker, Macaya Douoguih, Jeanne-Marie Jacquet
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 18, Iss 5 (2022)
An inactivated poliovirus vaccine candidate using Sabin strains (sIPV) grown on the PER.C6® cell line was assessed in infants after demonstrated immunogenicity and safety in adults. The study recruited 300 infants who were randomized (1:1:1:1) to re
Externí odkaz:
https://doaj.org/article/e15b3df185804c61b1c2049c272a25ed
Autor:
Christof Seiler, Anne-Maud Ferreira, Lisa M. Kronstad, Laura J. Simpson, Mathieu Le Gars, Elena Vendrame, Catherine A. Blish, Susan Holmes
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Background Flow and mass cytometry are important modern immunology tools for measuring expression levels of multiple proteins on single cells. The goal is to better understand the mechanisms of responses on a single cell basis by studying di
Externí odkaz:
https://doaj.org/article/27cc448bdff14d00a6742280b3778089
Autor:
Yumi Tsuchiya, Hiroshi Tamura, Koji Fujii, Hirotaka Numaguchi, Kiichiro Toyoizumi, Tina Liu, Mathieu Le Gars, Vicky Cárdenas, Takashi Eto
Publikováno v:
Vaccine. 41:1602-1610
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc4db91b8bee5c5ab7f3ba320550257a
https://doi.org/10.1016/j.vaccine.2023.01.006
https://doi.org/10.1016/j.vaccine.2023.01.006