Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mathieu Lachance"'
Autor:
Elsa Rossignol, Lara Eid, Praveen Kumar Raju, Ludmilla Lokmane, Samuel Boris Tene Tadoum, Xiao Jiang, Karolanne Toulouse, Alexis Lupien-Meilleur, François Charron-Ligez, Asmaa Toumi, Stephanie Backer, Mathieu Lachance, Marisol Lavertu-Jolin, Marie Montseny, Jean-Claude Lacaille, Evelyne Bloch-Gallego
Recessive mutations in the TRIO gene are associated with intellectual deficiency (ID), autism spectrum disorder (ASD) and developmental epileptic encephalopathies (DEE). TRIO is a dual guanine nucleotide exchange factor (GEF) that activates Rac1, Cdc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::122d11c9893b9b419ae75fdb59f866cf
https://doi.org/10.21203/rs.3.rs-2409410/v1
https://doi.org/10.21203/rs.3.rs-2409410/v1
Autor:
Mathieu Lachance, Francis Rosa
Publikováno v:
2022 IEEE Electrical Insulation Conference (EIC).
Publikováno v:
2021 IEEE Electrical Insulation Conference (EIC).
Autor:
Nazzareno D'Avanzo, Tyler Mark Pierson, Elsa Rossignol, Mathieu Lachance, Berge A. Minassian, Julie Pepin, Praveen K. Raju, Jean-Claude Lacaille, François Dubeau, Xiao Jiang, Luis Bello-Espinosa, Wendy G. Mitchell
Publikováno v:
Epilepsia. 60:1881-1894
Objective Developmental epileptic encephalopathies (DEEs) are genetically heterogeneous severe childhood-onset epilepsies with developmental delay or cognitive deficits. In this study, we explored the pathogenic mechanisms of DEE-associated de novo m
Autor:
Alexis Lupien-Meilleur, Elsa Rossignol, Louise Gagnon, Xiao Jiang, Catherine Vanasse, Mathieu Lachance, Vincent Taschereau-Dumouchel, Jean-Claude Lacaille
Publikováno v:
Molecular psychiatry. 26(12)
CACNA1A deletions cause epilepsy, ataxia, and a range of neurocognitive deficits, including inattention, impulsivity, intellectual deficiency and autism. To investigate the underlying mechanisms, we generated mice carrying a targeted Cacna1a deletion
Autor:
Roberto Araya, Mathieu Lachance, Jean-Claude Lacaille, Elsa Rossignol, Xiao Jiang, Elena Samarova, Alexis Lupien-Meilleur, Sabrina Tazerart
Publikováno v:
Annals of Neurology. 84:436-451
Objective Deletions of CACNA1A, encoding the α1 subunit of CaV 2.1 channels, cause epilepsy with ataxia in humans. Whereas the deletion of Cacna1a in γ-aminobutyric acidergic (GABAergic) interneurons (INs) derived from the medial ganglionic eminenc
Publikováno v:
Journal of Avian Medicine and Surgery. 33:381
Horner syndrome, which results from oculosympathetic denervation, has rarely been reported in birds. A retrospective study was conducted in a raptor rehabilitation program to gain further insight into Horner syndrome in birds. Data from 5128 live rap
Publikováno v:
Journal of Visualized Experiments.
GABAergic interneurons (INs) are critical components of neuronal networks that drive cognition and behavior. INs destined to populate the cortex migrate tangentially from their place of origin in the ventral telencephalon (including from the medial a
Publikováno v:
Progress in brain research. 226
GABAergic interneurons of the parvalbumin-positive fast-spiking basket cells subtype (PV INs) are important regulators of cortical network excitability and of gamma oscillations, involved in signal processing and cognition. Impaired development or fu
Autor:
Mathieu Lachance, Louis Saint-Amant, Joel Ryan, Ian G. Woods, Alexander F. Schier, Sean E. Low
Publikováno v:
Journal of Neurophysiology. 108:148-159
The molecular and physiological basis of the touch-unresponsive zebrafish mutant fakir has remained elusive. Here we report that the fakir phenotype is caused by a missense mutation in the gene encoding voltage-gated calcium channel 2.1b ( CACNA1Ab).