Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen

Autor: Mathieu Deygas, Rudy Gadet, Germain Gillet, Ruth Rimokh, Philippe Gonzalo, Ivan Mikaelian

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Aerotaxis, chemotaxis towards oxygen, occurs in bacteria and likely in cancer cells. Here the authors find that confined cells from different tissues escape hypoxia by aerotaxis, a process independent of mitochondria and the HIF pathway, and dependen

Externí odkaz: https://doaj.org/article/a4e51a68e65c470bac0c6a0d616c2971

Atypical CXCL12 signaling enhances neutrophil migration by modulating nuclear deformability

Autor: Bianca Calì, Mathieu Deygas, Fabio Munari, Elisabetta Marcuzzi, Antonino Cassará, Lara Toffali, Massimo Vetralla, Mathilde Bernard, Matthieu Piel, Onelia Gagliano, Marta Mastrogiovanni, Carlo Laudanna, Nicola Elvassore, Barbara Molon, Pablo Vargas, Antonella Viola

Publikováno v: Science Signaling. 15

To reach inflamed tissues from the circulation, neutrophils must overcome physical constraints imposed by the tissue architecture, such as the endothelial barrier or the three-dimensional (3D) interstitial space. In these microenvironments, neutrophi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326fdfdc1fbcad00e99fdce4d26c45cf
https://doi.org/10.1126/scisignal.abk2552

HIF2α is a direct regulator of neutrophil motility

Autor: Anja Krüger, Pablo J. Sáez, Alessandra Palladini, Ünal Coskun, Ioannis Kourtzelis, Ben Wielockx, Pablo Vargas, Jochen Guck, Sundary Sormendi, Gregoire Le Lay, Triantafyllos Chavakis, Ana Meneses, Mathilde Bernard, Martin Kräter, Anupam Sinha, Michael Gerlach, Mathieu Deygas, Kristin Franke

Publikováno v: Blood 137, 3416-3427 (2021)
Blood

Orchestrated recruitment of neutrophils to inflamed tissue is essential during initiation of inflammation. Inflamed areas are usually hypoxic, and adaptation to reduced oxygen pressure is typically mediated by hypoxia pathway proteins. However, it is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a16d554cddb1928ac205c116569a3b
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=61487

RNA Helicases DDX5 and DDX17 Dynamically Orchestrate Transcription, miRNA, and Splicing Programs in Cell Differentiation

Autor: Hussein Mortada, Lise Gratadou, Ruth Rimokh, Mathieu Deygas, Didier Auboeuf, Cyril F. Bourgeois, Samaan Samaan, Helen Neil, Eleonora Zonta, Micaela Polay Espinoza, Laurent Fattet, Fatima Zahra Chakrama, Martin Dutertre, Sophie Germann, François-Olivier Desmet, Marie-Pierre Lambert, Etienne Dardenne, Léon-Charles Tranchevent

Publikováno v: Cell Reports, Vol 7, Iss 6, Pp 1900-1913 (2014)

SummaryThe RNA helicases DDX5 and DDX17 are members of a large family of highly conserved proteins that are involved in gene-expression regulation; however, their in vivo targets and activities in biological processes such as cell differentiation, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6abe1c7cea58d2e451fc7d6062172b

TIF1γ interferes with TGFβ1/SMAD4 signaling to promote poor outcome in operable breast cancer patients

Autor: Isabelle Treilleux, Thomas Bachelot, Jonathan Lopez, Thibaut Goulvent, Mathieu Deygas, Emilie Lavergne, Nicolas Chopin, Nicolas Carrabin, Germain Gillet, Sylvie Chabaud, Ruth Rimokh, Laurent Fattet, Loay Kassem

Publikováno v: BMC Cancer
BMC Cancer, BioMed Central, 2015, 15, pp.453. ⟨10.1186/s12885-015-1471-y⟩
BMC Cancer, 2015, 15, pp.453. ⟨10.1186/s12885-015-1471-y⟩

Background The Transforming growth factor β (TGFβ) signaling has a paradoxical role in cancer development and outcome. Besides, the prognostic significance of the TGFβ1, SMAD4 in breast cancer patients is an area of many contradictions. The transc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7688db8e8515fd76339dd0f5001bcc6
https://www.hal.inserm.fr/inserm-01188071/file/s12885-015-1471-y.pdf