Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Mathieu, Dubé"'
Autor:
Jonathan Richard, Gérémy Sannier, Li Zhu, Jérémie Prévost, Lorie Marchitto, Mehdi Benlarbi, Guillaume Beaudoin-Bussières, Hongil Kim, Yaping Sun, Debashree Chatterjee, Halima Medjahed, Catherine Bourassa, Gloria-Gabrielle Delgado, Mathieu Dubé, Frank Kirchhoff, Beatrice H. Hahn, Priti Kumar, Daniel E. Kaufmann, Andrés Finzi
Publikováno v:
mBio, Vol 15, Iss 11 (2024)
ABSTRACT HIV-1 envelope glycoprotein (Env) conformation substantially impacts antibody-dependent cellular cytotoxicity (ADCC). Envs from primary HIV-1 isolates adopt a prefusion “closed” conformation, which is targeted by broadly neutralizing ant
Externí odkaz:
https://doaj.org/article/e5ef3dc6caf5435fa447f314f7bf4a25
Autor:
Alexandre Nicolas, Gérémy Sannier, Mathieu Dubé, Manon Nayrac, Alexandra Tauzin, Mark M. Painter, Rishi R. Goel, Mélanie Laporte, Gabrielle Gendron-Lepage, Halima Medjahed, Justine C. Williams, Nathalie Brassard, Julia Niessl, Laurie Gokool, Chantal Morrisseau, Pascale Arlotto, Cécile Tremblay, Valérie Martel-Laferrière, Andrés Finzi, Allison R. Greenplate, E. John Wherry, Daniel E. Kaufmann
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105904- (2023)
Summary: Spacing the first two doses of SARS-CoV-2 mRNA vaccines beyond 3–4 weeks raised initial concerns about vaccine efficacy. While studies have since shown that long-interval regimens induce robust antibody responses, their impact on B and T c
Externí odkaz:
https://doaj.org/article/cb87a511664f4979acf3c0bb560c1dde
Autor:
Elsa Brunet-Ratnasingham, Antigoni Morou, Mathieu Dubé, Julia Niessl, Amy E. Baxter, Olivier Tastet, Nathalie Brassard, Gloria Ortega-Delgado, Roxanne Charlebois, Gordon J. Freeman, Cécile Tremblay, Jean-Pierre Routy, Daniel E. Kaufmann
Publikováno v:
EBioMedicine, Vol 84, Iss , Pp 104254- (2022)
Summary: Background: Immune checkpoint blockade (ICB) partially reverses the dysfunctional state of antigen-specific T cell in chronic infections. However, its impact on the diverse subsets of CD4+ T cells in humans is largely unknown. Methods: We ex
Externí odkaz:
https://doaj.org/article/5afb9923fb4d41e4805be2e33fee7a57
Autor:
Alexandra Tauzin, Gabrielle Gendron-Lepage, Manon Nayrac, Sai Priya Anand, Catherine Bourassa, Halima Medjahed, Guillaume Goyette, Mathieu Dubé, Renée Bazin, Daniel E. Kaufmann, Andrés Finzi
Publikováno v:
Viruses, Vol 14, Iss 3, p 532 (2022)
SARS-CoV-2 infection rapidly elicits anti-Spike antibodies whose quantity in plasma gradually declines upon resolution of symptoms. This decline is part of the evolution of an immune response leading to B cell differentiation into short-lived antibod
Externí odkaz:
https://doaj.org/article/fc18a81e44324399bc198b3c2281f6e0
Autor:
Julia Niessl, Amy E. Baxter, Antigoni Morou, Elsa Brunet-Ratnasingham, Gérémy Sannier, Gabrielle Gendron-Lepage, Jonathan Richard, Gloria-Gabrielle Delgado, Nathalie Brassard, Isabelle Turcotte, Rémi Fromentin, Nicole F. Bernard, Nicolas Chomont, Jean-Pierre Routy, Mathieu Dubé, Andrés Finzi, Daniel E. Kaufmann
Publikováno v:
EBioMedicine, Vol 54, Iss , Pp - (2020)
Background: Untreated HIV infection leads to alterations in HIV-specific CD4+ T cells including increased expression of co-inhibitory receptors (IRs) and skewing toward a T follicular helper cell (Tfh) signature. However, which changes are maintained
Externí odkaz:
https://doaj.org/article/b9c632e219604240ae02b8e6379da988
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
The need for definitive answers probably explains our natural tendency to seek simplicity. The reductionist “bulk” approach, in which a mean behavior is attributed to a heterogeneous cell population, fulfills this need by considerably helping the
Externí odkaz:
https://doaj.org/article/05a8051a85394443afd400b5e282acf0
Autor:
Jérémie Prévost, Suzanne Pickering, Mitchell J. Mumby, Halima Medjahed, Gabrielle Gendron-Lepage, Gloria G. Delgado, Brennan S. Dirk, Jimmy D. Dikeakos, Christina M. Stürzel, Daniel Sauter, Frank Kirchhoff, Frederic Bibollet-Ruche, Beatrice H. Hahn, Mathieu Dubé, Daniel E. Kaufmann, Stuart J. D. Neil, Andrés Finzi, Jonathan Richard
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT The HIV-1 accessory protein Vpu enhances viral release by counteracting the restriction factor BST-2. Furthermore, Vpu promotes NK cell evasion by downmodulating cell surface NTB-A and PVR, known ligands of the NK cell receptors NTB-A and DN
Externí odkaz:
https://doaj.org/article/a9c7f1cd222240a497b7cabeef046a5f
Publikováno v:
Viruses, Vol 7, Iss 4, Pp 2147-2167 (2015)
Alphaviruses such as chikungunya virus (CHIKV) and Semliki Forest virus (SFV) are small enveloped RNA viruses that bud from the plasma membrane. Tetherin/BST2 is an interferon-induced host membrane protein that inhibits the release of many enveloped
Externí odkaz:
https://doaj.org/article/255822c8f1194e118084b9ade7cdfcc0
Autor:
Gérémy Sannier, Alexandre Nicolas, Mathieu Dubé, Lorie Marchitto, Manon Nayrac, Olivier Tastet, Alexandra Tauzin, Raphaël Lima-Barbosa, Mélanie Laporte, Rose Cloutier, Alina Sreng Flores, Marianne Boutin, Shang Yu Gong, Mehdi Benlarbi, Shilei Ding, Catherine Bourassa, Gabrielle Gendron-Lepage, Halima Medjahed, Guillaume Goyette, Nathalie Brassard, Gloria-Gabrielle Ortega-Delgado, Julia Niessl, Laurie Gokool, Chantal Morrisseau, Pascale Arlotto, Norka Rios, Cécile Tremblay, Valérie Martel-Laferrière, Alexandre Prat, Justin Bélair, William Beaubien-Souligny, Rémi Goupil, Annie-Claire Nadeau-Fredette, Caroline Lamarche, Andrés Finzi, Rita S. Suri, Daniel E. Kaufmann
Cellular immune defects associated with suboptimal responses to SARS-CoV-2 mRNA vaccination in people receiving hemodialysis (HD) are poorly understood. We longitudinally analyzed antibody, B cell, CD4+ and CD8+ T cell vaccine responses in 27 HD pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a632be7466520b808ebf6ca712c2aad
https://doi.org/10.1101/2022.09.05.506622
https://doi.org/10.1101/2022.09.05.506622
Autor:
Alexandre Nicolas, Gérémy Sannier, Mathieu Dubé, Manon Nayrac, Mark M. Painter, Rishi R. Goel, Mélanie Laporte, Halima Medjahed, Justine C. Williams, Nathalie Brassard, Julia Niessl, Laurie Gokool, Chantal Morrisseau, Pascale Arlotto, Cécile Tremblay, Valérie Martel-Laferrière, Andrés Finzi, Allison R. Greenplate, E. John Wherry, Daniel E. Kaufmann
SUMMARYSpacing the first two doses of SARS-CoV-2 mRNA vaccines beyond 3-4 weeks raised initial concerns about vaccine efficacy. While studies have since shown that long-interval regimens induce robust antibody responses, their impact on B and T cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f43ad386718a907b6def47c102af1f
https://doi.org/10.1101/2022.08.03.502672
https://doi.org/10.1101/2022.08.03.502672