Methotrexate treatment hampers induction of vaccine-specific CD4 T cell responses in patients with IMID

Autor: Sander W Tas, Joep Killestein, Joost Raaphorst, Taco W Kuijpers, Alexandre E Voskuyl, Gertjan Wolbink, Theo Rispens, Anneke J van der Kooi, Anja Ten Brinke, Karina de Leeuw, Abraham Rutgers, Juan J Garcia-Vallejo, Frederike J Bemelman, YK Onno Teng, Phyllis I Spuls, Mark Löwenberg, Jelle de Wit, Diane van der Woude, Marcel W Bekkenk, Luuk Wieske, Esther Brusse, Laura Boekel, Filip Eftimov, Eileen W Stalman, Maurice Steenhuis, Sofie Keijzer, Olvi Cristianawati, Koos P J van Dam, Adriaan G Volkers, Annelie H Musters, Nicoline F Post, Angela L Bosma, Marc L Hilhorst, Yosta Vegting, Bo Broens, Barbara Horváth, Annabel M Ruiter, Matthias H Busch, Dirk Jan Hijnen, Niels J M Verstegen, Pieter A van Doorn, Jan JGM Verschuuren, Laura Y L Kummer, Ruth R Hagen, Christine Kreher, Lisan H Kuijper, Mariël C Duurland, Veronique A L Konijn, Carolien E van de Sandt, Laura Fernández Blanco, Amélie Bos, Charlotte Menage, Tineke Jorritsma, Jet van den Dijssel, Rivka de Jongh, Tom Ashhurst, Marit J van Gils, Mathieu Claireaux, Sija Marieke van Ham, Renée CF van Allaart, Adája E Baars, George Elias, Cécile ACM van Els, H Stephan Goedee, Geert RAM D’Haens, Papay BP Jallah, Elham S Mirfazeli, Jim BD Keijser, Lotte van Ouwerkerk, Pieter van Paassen, Agner R Parra Sanchez, W Ludo van der Pol, Corine RG Schreurs, R Bart Takkenberg, Koos AH Zwinderman

Publikováno v: RMD Open, Vol 10, Iss 4 (2024)

Objectives Methotrexate (MTX) is one of the most commonly used medications to treat rheumatoid arthritis (RA). However, the effect of MTX treatment on cellular immune responses remains incompletely understood. This raises concerns about the vulnerabi

Externí odkaz: https://doaj.org/article/afff65e4600e4deabe9d42545d2637c0

Systematic evaluation of B-cell clonal family inference approaches

Autor: Daria Balashova, Barbera D. C. van Schaik, Maria Stratigopoulou, Jeroen E. J. Guikema, Tom G. Caniels, Mathieu Claireaux, Marit J. van Gils, Anne Musters, Dornatien C. Anang, Niek de Vries, Victor Greiff, Antoine H. C. van Kampen

Publikováno v: BMC Immunology, Vol 25, Iss 1, Pp 1-22 (2024)

Abstract The reconstruction of clonal families (CFs) in B-cell receptor (BCR) repertoire analysis is a crucial step to understand the adaptive immune system and how it responds to antigens. The BCR repertoire of an individual is formed throughout lif

Externí odkaz: https://doaj.org/article/4721851a60424610a3e66446a8304cfe

A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike

Autor: Mathieu Claireaux, Tom G. Caniels, Marlon de Gast, Julianna Han, Denise Guerra, Gius Kerster, Barbera D. C. van Schaik, Aldo Jongejan, Angela I. Schriek, Marloes Grobben, Philip J. M. Brouwer, Karlijn van der Straten, Yoann Aldon, Joan Capella-Pujol, Jonne L. Snitselaar, Wouter Olijhoek, Aafke Aartse, Mitch Brinkkemper, Ilja Bontjer, Judith A. Burger, Meliawati Poniman, Tom P. L. Bijl, Jonathan L. Torres, Jeffrey Copps, Isabel Cuella Martin, Steven W. de Taeye, Godelieve J. de Bree, Andrew B. Ward, Kwinten Sliepen, Antoine H. C. van Kampen, Perry D. Moerland, Rogier W. Sanders, Marit J. van Gils

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

To fully understand the potential shortcomings of SARS-CoV-2 vaccination, it is necessary to delineate the properties of the antibodies elicited, during immunization, and also infection. Through investigation of the SARS-CoV-2 spike-reactive B cell r

Externí odkaz: https://doaj.org/article/86312e11f65b467f911c74e87e292a4a

Primary antibody response after influenza virus infection is first dominated by low-mutated HA-stem antibodies followed by higher-mutated HA-head antibodies

Autor: Aafke Aartse, Daniella Mortier, Petra Mooij, Sam Hofman, Marlies M. van Haaren, Martin Corcoran, Gunilla B. Karlsson Hedestam, Dirk Eggink, Mathieu Claireaux, Willy M. J. M. Bogers, Marit J. van Gils, Gerrit Koopman

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Several studies have shown that the first encounter with influenza virus shapes the immune response to future infections or vaccinations. However, a detailed analysis of the primary antibody response is lacking as this is difficult to study in humans

Externí odkaz: https://doaj.org/article/ed98b50c9d954d01b3e2bfe78460e7bc

Distinct dynamics of antigen-specific induction and differentiation of different CD11c + Tbet + B cell subsets

Autor: Juulke Steuten, Amélie V. Bos, Lisan H. Kuijper, Mathieu Claireaux, Wouter Olijhoek, George Elias, Mariel C. Duurland, Tineke Jorritsma, Casper Marsman, Alberta G.A. Paul, Juan J. Garcia Vallejo, Marit J. van Gils, Luuk Wieske, Taco W. Kuijpers, Filip Eftimov, S. Marieke van Ham, Anja ten Brinke

Publikováno v: Journal of Allergy and Clinical Immunology. Mosby Inc.
T2B Consortium 2023, ' Distinct dynamics of antigen-specific induction and differentiation of different CD11c + Tbet + B cell subsets. ', Journal of Allergy and Clinical Immunology . https://doi.org/10.1016/j.jaci.2023.02.020
Journal of allergy and clinical immunology. Mosby Inc.

Background: CD11c +Tbet + B cells are enriched in autoimmunity and chronic infections and also expand on immune challenge in healthy individuals. CD11c +Tbet + B cells remain an enigmatic B-cell population because of their intrinsic heterogeneity. Ob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::604f718f52008bcbcb9e655ea8e887ef
https://research.vumc.nl/en/publications/175c9325-86e9-453d-93da-3a5bd11c29c6