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Impact of methodological choices in comparative effectiveness studies: application in natalizumab versus fingolimod comparison among patients with multiple sclerosis.

Autor: Lefort M; Arènes - UMR 6051, RSMS (Recherche sur les Services et Management en Santé) - U 1309, Univ Rennes, EHESP, CNRS, Inserm, Rennes, France.; Univ Rennes, CHU Rennes, Investigation Clinique de Rennes)], CIC 1414 [(Centre d, 35000, InsermRennes, France., Sharmin S; Department of Medicine, University of Melbourne, Melbourne, Australia.; Melbourne MS Centre, Department of Neurology, Royal Melbourne Hospital, Melbourne, Australia., Andersen JB; Department of Neurology, The Danish Multiple Sclerosis Registry, Copenhagen University Hospital, Rigshospitalet Glostrup, Denmark., Vukusic S; Service de Neurologie, Sclérose en Plaques, Pathologies de La Myéline Et Neuro-Inflammation, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, 69677, Lyon/Bron, France.; Centre Des Neurosciences de Lyon, UMR5292, Observatoire Français de La Sclérose en Plaques, INSERM, 1028 et CNRS, 69003, Lyon, France.; Université, Claude Bernard Lyon 1, Faculté de médecine Lyon Est, 69000, Lyon, France., Casey R; Service de Neurologie, Sclérose en Plaques, Pathologies de La Myéline Et Neuro-Inflammation, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, 69677, Lyon/Bron, France.; Centre Des Neurosciences de Lyon, UMR5292, Observatoire Français de La Sclérose en Plaques, INSERM, 1028 et CNRS, 69003, Lyon, France.; Université, Claude Bernard Lyon 1, Faculté de médecine Lyon Est, 69000, Lyon, France.; Eugene Devic EDMUS Foundation, 69677, Lyon/Bron, France., Debouverie M; Centre Hospitalier Régional Universitaire de Nancy, Hôpital Central, Service de neurologie, Nancy, France., Edan G; Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou, Service de neurologie, Rennes, France., Ciron J; Centre Hospitalier Universitaire de Toulouse, Hôpital Purpan, CRC-SEP, Département de neurologie, Toulouse, France., Ruet A; Centre Hospitalier Universitaire de Bordeaux, Hôpital Pellegrin, Service de neurologie, Bordeaux, France., De Sèze J; Service des maladies inflammatoires du système nerveux - neurologie, centre d'investigation clinique de Strasbourg, Hôpitaux Universitaire de Strasbourg, Hôpital de Hautepierre, INSERM 1434, Strasbourg, France., Maillart E; Assistance Publique Des Hôpitaux de Paris, Hôpital de La Pitié-Salpêtrière, Service de neurologie, Paris, France., Zephir H; Centre Hospitalier Universitaire de Lille, Hôpital Salengro, Service de neurologie D, Lille, France., Labauge P; Centre Hospitalier Universitaire de Montpellier, Hôpital Gui de Chauliac, Service de neurologie, Montpellier, France., Defer G; Centre Hospitalier Universitaire de Caen Normandie, Hôpital Côte de Nacre, Service de neurologie, Caen, France., Lebrun-Frenay C; Centre Hospitalier Universitaire de Nice, UR2CA-URRIS,, Université Nice Côte d'Azur, Hôpital, Pasteur 2, Service de neurologie, Nice, France., Moreau T; Centre Hospitalier Universitaire Dijon Bourgogne, Hôpital François Mitterrand, Maladies Inflammatoires du Système Nerveux Et Neurologie Générale, Service de neurologie, Dijon, France., Berger E; Centre Hospitalier Régional Universitaire de Besançon, Hôpital Jean Minjoz, Service de neurologie, Besançon, France., Clavelou P; Centre Hospitalier Universitaire de Clermont-Ferrand, Hôpital Gabriel-Montpied, Service de neurologie, Clermont-Ferrand, France., Pelletier J; Service de Neurologie, Aix Marseille Univ, APHM, Hôpital de La Timone, Pôle de Neurosciences Cliniques, 13005, Marseille, France., Stankoff B; Assistance Publique Des Hôpitaux de Paris, Hôpital Saint-Antoine, Service de neurologie, Paris, France., Gout O; Fondation Adolphe de Rothschild de L'œil Et du Cerveau, Service de neurologie, Paris, France., Thouvenot E; Centre Hospitalier Universitaire de Nîmes, Hôpital Carémeau, Service de neurologie, Nîmes, France., Heinzlef O; Centre Hospitalier Intercommunal de Poissy Saint-Germain-en-Laye, Service de neurologie, Poissy, France., Al-Khedr A; Centre Hospitalier Universitaire d'Amiens Picardie, Site sud, Service de neurologie, Amiens, France., Bourre B; Rouen University Hospital, 76000, Rouen, France., Casez O; Centre Hospitalier Universitaire Grenoble-Alpes, Site nord, Service de neurologie, Grenoble/La Tronche, France., Cabre P; Centre Hospitalier Universitaire de Martinique, Hôpital Pierre Zobda-Quitman, Service de neurologie, Fort-de-France, France., Montcuquet A; Centre Hospitalier Universitaire Limoges, Hôpital Dupuytren, Service de neurologie, Limoges, France., Wahab A; Assistance Publique Des Hôpitaux de Paris, Hôpital Henri Mondor, Service de neurologie, Créteil, France., Camdessanché JP; Centre Hospitalier Universitaire de Saint-Étienne, Hôpital Nord, Service de neurologie, Saint-Étienne, France., Maurousset A; Centre Hospitalier Régional Universitaire de Tours, Hôpital Bretonneau, Service de neurologie, Tours, France., Ben Nasr H; Centre Hospitalier Sud Francilien, Service de neurologie, Corbeil-Essonnes, France., Hankiewicz K; Centre Hospitalier de Saint-Denis, Hôpital Casanova, Service de neurologie, Saint-Denis, France., Pottier C; Centre Hospitalier de Pontoise, Service de neurologie, Pontoise, France., Maubeuge N; Centre Hospitalier Universitaire de Poitiers, Site de La Milétrie, Service de neurologie, Poitiers, France., Dimitri-Boulos D; Assistance Publique Des Hôpitaux de Paris, Hôpital Bicêtre, Service de neurologie, Le Kremlin-Bicêtre, France., Nifle C; Centre Hospitalier de Versailles, Hôpital André-Mignot, Service de neurologie, Le Chesnay, France., Laplaud DA; CHU de Nantes, Service de Neurologie & CIC015 INSERM, 44093, Nantes, France.; INSERM CR1064, 44000, Nantes, France., Horakova D; Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic., Havrdova EK; Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic., Alroughani R; Division of Neurology, Department of Medicine, Amiri Hospital, Sharq, Kuwait., Izquierdo G; Hospital Universitario Virgen Macarena, Seville, Spain., Eichau S; Hospital Universitario Virgen Macarena, Seville, Spain., Ozakbas S; Dokuz Eylul University, Konak/Izmir, Turkey., Patti F; GF Ingrassia Department, University of Catania, Catania, Italy.; Policlinico G Rodolico, Catania, Italy., Onofrj M; Department of Neuroscience, Imaging, and Clinical Sciences, University G. d'Annunzio, Chieti, Italy., Lugaresi A; Dipartimento Di Scienze Biomediche E Neuromotorie, Università Di Bologna, Bologna, Italy.; IRCCS Istituto Delle Scienze Neurologiche Di Bologna, Bologna, Italy., Terzi M; Medical Faculty, 19 Mayis University, Samsun, Turkey., Grammond P; CISSS Chaudiere-Appalache, Levis, Canada., Grand'Maison F; Neuro Rive-Sud, Longueuil, QC, Canada., Yamout B; Nehme and Therese Tohme Multiple Sclerosis Center, American University of Beirut Medical Center, Beirut, Lebanon., Prat A; Hopital Notre Dame, Montreal, Canada.; CHUM and Universite de Montreal, Montreal, Canada., Girard M; Hopital Notre Dame, Montreal, Canada.; CHUM and Universite de Montreal, Montreal, Canada., Duquette P; Hopital Notre Dame, Montreal, Canada.; CHUM and Universite de Montreal, Montreal, Canada., Boz C; KTU Medical Faculty Farabi Hospital, Trabzon, Turkey., Trojano M; Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, Bari, Italy., McCombe P; University of Queensland, Brisbane, Australia.; Royal Brisbane and Women's Hospital, Herston, Australia., Slee M; Flinders University, Adelaide, Australia., Lechner-Scott J; School of Medicine and Public Health, University Newcastle, Newcastle, Australia.; Department of Neurology, John Hunter Hospital, Hunter New England Health, Newcastle, Australia., Turkoglu R; Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey., Sola P; Department of Neuroscience, Azienda Ospedaliera Universitaria, Modena, Italy., Ferraro D; Department of Neuroscience, Azienda Ospedaliera Universitaria, Modena, Italy., Granella F; Department of Medicine and Surgery, University of Parma, Parma, Italy.; Department of Emergency and General Medicine, Parma University Hospital, Parma, Italy., Shaygannejad V; Isfahan University of Medical Sciences, Isfahan, Iran., Prevost J; CSSS Saint-Jérôme, Saint-Jerome, Canada., Maimone D; Garibaldi Hospital, Catania, Italy., Skibina O; Monash University, Melbourne, Australia., Buzzard K; Monash University, Melbourne, Australia., Van der Walt A; Monash University, Melbourne, Australia., Karabudak R; Hacettepe University, Ankara, Turkey., Van Wijmeersch B; Rehabilitation and MS-Centre Overpelt and Hasselt University, Hasselt, Belgium., Csepany T; Department of Neurology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Spitaleri D; Azienda Ospedaliera Di Rilievo Nazionale San Giuseppe Moscati Avellino, Avellino, Italy., Vucic S; Westmead Hospital, Sydney, Australia., Koch-Henriksen N; Department of Clinical Epidemiology, Aarhus University Hospital Aarhus, Aarhus, Denmark., Sellebjerg F; Danish Multiple Sclerosis Centre, Department of Neurology, Copenhagen University Hospital, Rigshospitalet Glostrup, 2600, Glostrup, Denmark., Soerensen PS; Danish Multiple Sclerosis Centre, Department of Neurology, Copenhagen University Hospital, Rigshospitalet Glostrup, 2600, Glostrup, Denmark., Hilt Christensen CC; Department of Neurology, Aalborg University Hospital, Multiple Sclerosis Unit, Aalborg, Denmark., Rasmussen PV; Aarhus University Hospital, Neurology, PJJ Boulevard, DK-8200, Aarhus N, Denmark., Jensen MB; Department of Neurology, University Hospital of Northern Sealand, Copenhagen, Denmark., Frederiksen JL; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Bramow S; Danish Multiple Sclerosis Centre, Department of Neurology, Copenhagen University Hospital, Rigshospitalet Glostrup, 2600, Glostrup, Denmark., Mathiesen HK; Department of Neurology, Copenhagen University Hospital Herlev, Copenhagen, Denmark., Schreiber KI; Danish Multiple Sclerosis Centre, Department of Neurology, Copenhagen University Hospital, Rigshospitalet Glostrup, 2600, Glostrup, Denmark., Butzkueven H; Central Clinical School, Monash University, Melbourne, Australia.; Department of Neurology, The Alfred Hospital, Melbourne, Australia.; Department of Neurology, Box Hill Hospital, Monash University, Melbourne, Australia., Magyari M; Melbourne MS Centre, Department of Neurology, Royal Melbourne Hospital, Melbourne, Australia.; Danish Multiple Sclerosis Centre, Department of Neurology, Copenhagen University Hospital, Rigshospitalet Glostrup, 2600, Glostrup, Denmark., Kalincik T; Department of Medicine, University of Melbourne, Melbourne, Australia. tomas.kalincik@unimelb.edu.au., Leray E; Arènes - UMR 6051, RSMS (Recherche sur les Services et Management en Santé) - U 1309, Univ Rennes, EHESP, CNRS, Inserm, Rennes, France. emmanuelle.leray@ehesp.fr.; Univ Rennes, CHU Rennes, Investigation Clinique de Rennes)], CIC 1414 [(Centre d, 35000, InsermRennes, France. emmanuelle.leray@ehesp.fr.

Publikováno v: BMC medical research methodology [BMC Med Res Methodol] 2022 May 30; Vol. 22 (1), pp. 155. Date of Electronic Publication: 2022 May 30.

Natalizumab Versus Fingolimod in Patients with Relapsing-Remitting Multiple Sclerosis: A Subgroup Analysis From Three International Cohorts.

Autor: Sharmin S; CORe, Department of Medicine, University of Melbourne, L4 East, Grattan St, Melbourne, VIC, 3050, Australia., Lefort M; Rennes University, EHESP, REPERES, EA, 7449, Rennes, France.; Univ Rennes, CHU Rennes, Inserm, CIC 1414 (Centre d'Investigation Clinique de Rennes), Rennes, France., Andersen JB; The Danish Multiple Sclerosis Registry, Department of Neurology, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark., Leray E; Rennes University, EHESP, REPERES, EA, 7449, Rennes, France.; Univ Rennes, CHU Rennes, Inserm, CIC 1414 (Centre d'Investigation Clinique de Rennes), Rennes, France., Horakova D; Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic., Havrdova EK; Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic., Alroughani R; Division of Neurology, Department of Medicine, Amiri Hospital, Sharq, Kuwait., Izquierdo G; Hospital Universitario Virgen Macarena, Seville, Spain., Ozakbas S; Dokuz Eylul University, Konak, Izmir, Turkey., Patti F; Department of Medical and Surgical Sciences and Advanced Technologies, GF Ingrassia, Catania, Italy.; Multiple Sclerosis Center, University of Catania, Catania, Italy., Onofrj M; Department of Neuroscience, Imaging, and Clinical Sciences, University G. d'Annunzio, Chieti, Italy., Lugaresi A; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.; Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italia., Terzi M; Medical Faculty, 19 Mayis University, Samsun, Turkey., Grammond P; CISSS Chaudière-Appalache, Levis, Canada., Grand'Maison F; Neuro Rive-Sud, Greenfield Park, Quebec, Canada., Yamout B; Nehme and Therese Tohme Multiple Sclerosis Center, American University of Beirut Medical Center, Beirut, Lebanon., Prat A; CHUM MS Center and Universite de Montreal, Montreal, Canada., Girard M; CHUM MS Center and Universite de Montreal, Montreal, Canada., Duquette P; CHUM MS Center and Universite de Montreal, Montreal, Canada., Boz C; KTU Medical Faculty Farabi Hospital, Trabzon, Turkey., Trojano M; Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, Bari, Italy., McCombe P; University of Queensland, Brisbane, Australia.; Royal Brisbane and Women's Hospital, Brisbane, Australia., Slee M; College of Medicine and Public Health, Flinders University, Adelaide, Australia., Lechner-Scott J; School of Medicine and Public Health, University Newcastle, Newcastle, Australia.; Department of Neurology, John Hunter Hospital, Hunter New England Health, Newcastle, Australia., Turkoglu R; Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey., Sola P; Department of Neuroscience, Azienda Ospedaliera Universitaria, Modena, Italy., Ferraro D; Department of Neuroscience, Azienda Ospedaliera Universitaria, Modena, Italy., Granella F; Department of Medicine and Surgery, University of Parma, Parma, Italy.; Department of Emergency and General Medicine, Parma University Hospital, Parma, Italy., Prevost J; CSSS Saint-Jérôme, Saint-Jerome, Canada., Maimone D; Neurology Unit, Garibaldi Hospital, Catania, Italy., Skibina O; Department of Neuroscience, Monash University, Melbourne, Australia.; Department of Neurology, The Alfred Hospital, Melbourne, Australia., Buzzard K; Department of Neurology, The Alfred Hospital, Melbourne, Australia.; Central Clinical School, Monash University, Melbourne, Australia., Van der Walt A; Department of Neurology, The Alfred Hospital, Melbourne, Australia.; Central Clinical School, Monash University, Melbourne, Australia., Van Wijmeersch B; Rehabilitation and MS-Centre Overpelt and Hasselt University, Hasselt, Belgium., Csepany T; Department of Neurology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Spitaleri D; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino, Avellino, Italy., Vucic S; Neurophysiology Department, Westmead Hospital, Sydney, Australia., Casey R; Université de Lyon, Université, Claude Bernard Lyon 1, F-69000, Lyon, France.; Service de neurologie, sclérose en plaques, pathologies de la myéline et neuro-inflammation, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Bron, Lyon, France.; Observatoire Français de la Sclérose en Plaques, Centre de Recherche en Neurosciences de Lyon, INSERM 1028 et CNRS UMR 5292, 69003, Lyon, France.; EUGENE DEVIC EDMUS Foundation Against Multiple Sclerosis, State-Approved Foundation, 69677, Bron, France., Debouverie M; Department of Neurology, Nancy University Hospital, Nancy, France.; Université de Lorraine, APEMAC, 54000, Nancy, France., Edan G; CHU Pontchaillou, CIC1414 INSERM, 35000, Rennes, France., Ciron J; Department of Neurology, CHU de Toulouse, Hôpital Pierre-Paul Riquet, CRC-SEP, 31059, Toulouse Cedex 9, France., Ruet A; Neurocentre Magendie, Université de Bordeaux, 33000, Bordeaux, France.; INSERM U1215, Neurocentre Magendie, 33000, Bordeaux, France.; Department of Neurology, CHU de Bordeaux, CIC Bordeaux CIC1401, 33000, Bordeaux, France., De Sèze J; Department of Neurology and Clinical Investigation Center, CHU de Strasbourg, CIC 1434, INSERM 1434, 67000, Strasbourg, France., Maillart E; Département de neurologie, Hôpital Pitié-Salpêtrière, APHP, Paris, France.; Centre de Ressources et de Compétences SEP, Paris, France., Zephir H; CHU Lille, CRCSEP Lille, Univ Lille, U1172, 59000, Lille, France., Labauge P; MS Unit, CHU de Montpellier, 34295, Montpellier Cedex 5, France.; University of Montpellier (MUSE), 34000, Montpellier, France., Defer G; Department of Neurology, CHU de Caen, MS Expert Centre, Normandy University, avenue de la Côte-de-Nacre, 14033, Caen, France., Lebrun-Frénay C; CRCSEP Nice, UR2CA, Université Nice Cote d'Azur, Hopital Pasteur2, 06002, Nice, France., Moreau T; Department of Neurology, CHU de Dijon, EA4184, 21000, Dijon, France., Berger E; CHU de Besançon, Service de Neurologie 25 030, Besançon, France., Clavelou P; Department of Neurology, CHU Clermont-Ferrand, 63000, Clermont-Ferrand, France.; Université Clermont Auvergne, Inserm, Neuro-Dol, 63000, Clermont-Ferrand, France., Pelletier J; Aix Marseille Univ, APHM, Hôpital de la Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, 13005, Marseille, France., Stankoff B; Sorbonne Universités, UPMC Paris 06, Brain and Spine Institute, ICM, Hôpital de la Pitié Salpêtrière, Inserm UMR S 1127, CNRS UMR 7225, Paris, France.; Department of Neurology, AP-HP, Saint-Antoine Hospital, 75000, Paris, France., Gout O; Department of Neurology, Fondation Rotschild, 75000, Paris, France., Thouvenot E; Department of Neurology, Nimes University Hospital, 30029, Nimes Cedex 9, France.; Institut de Génomique Fonctionnelle, UMR5203, INSERM 1191, Univ. Montpellier, 34094, Montpellier Cedex 5, France., Heinzlef O; Department of Neurology, Hôpital de Poissy, 78300, Poissy, France., Al-Khedr A; Department of Neurology, CHU d'Amiens, 80000, Amiens, France., Bourre B; Department of Neurology, CHU de Rouen, 76000, Rouen, France., Casez O; Department of Neurology, CHU Grenoble Alpes, La Tronche, 38700, Grenoble, France., Cabre P; Department of Neurology, CHU de la Martinique, 97200, Fort-de-France, France., Montcuquet A; Department of Neurology, CHU de Limoges, Hôpital Dupuytren, 87000, Limoges, France., Wahab A; Department of Neurology, APHP, Hôpital Henri Mondor, 94000, Créteil, France., Camdessanché JP; Department of Neurology, CHU de Saint-Étienne, Hôpital Nord, 42000, Saint-Étienne, France., Maurousset A; CRC SEP and Department of Neurology, CHU de Tours, Hôpital Bretonneau, 37000, Tours, France., Patry I; Department of Neurology, Hôpital Sud Francilien, 91160, Corbeil Essonnes, France., Hankiewicz K; Department of Neurology, Hôpital Pierre Delafontaine, Centre Hospitalier de Saint-Denis, 93200, Saint-Denis, France., Pottier C; Department of Neurology, CH de Pontoise, Hôpital René Dubos, 95300, Pontoise, France., Maubeuge N; Department of Neurology, CHU La Milétrie, Hôpital Jean Bernard, 86000, Poitiers, France., Labeyrie C; Department of Neurology, CHU Bicêtre, 94275, Le Kremlin Bicêtre, France., Nifle C; Department of Neurology, Centre Hospitalier de Versailles, 78150, Le Chesnay, France., Laplaud D; CHU de Nantes, Service de Neurologie & CIC015 INSERM, 44093, Nantes, France.; CRTI-Inserm U1064, 44000, Nantes, France., Koch-Henriksen N; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark., Sellebjerg FT; Department of Neurology, The Danish Multiple Sclerosis Center, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark., Soerensen PS; Department of Neurology, The Danish Multiple Sclerosis Center, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark., Pfleger CC; Multiple Sclerosis Unit, Department of Neurology, Aalborg University Hospital, Aalborg, Denmark., Rasmussen PV; Aarhus University Hospital, Neurology, PPJ Boulevard, 8200, Aarhus N, Denmark., Jensen MB; Department of Neurology, University Hospital of Northern Sealand, Helsingør, Denmark., Frederiksen JL; Department of Neurology, Rigshospitalet Glostrup, Copenhagen, Denmark.; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Bramow S; Department of Neurology, Danish Multiple Sclerosis Centre, Copenhagen University Hospital, Rigshospitalet in Glostrup, 2600, Glostrup, Denmark., Mathiesen HK; Department of Neurology, Copenhagen University Hospital Herlev, Herlev, Denmark., Schreiber KI; Department of Neurology, The Danish Multiple Sclerosis Center, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark., Magyari M; The Danish Multiple Sclerosis Registry, Department of Neurology, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark.; Department of Neurology, The Danish Multiple Sclerosis Center, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark., Vukusic S; Service de neurologie, sclérose en plaques, pathologies de la myéline et neuro-inflammation, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Bron, Lyon, France.; Centre des Neurosciences de Lyon, Observatoire Français de la Sclérose en Plaques, INSERM 1028 et CNRS UMR5292, 69003, Lyon, France.; Université Claude Bernard Lyon 1, Faculté de médecine Lyon Est, F-69000, Lyon, France., Butzkueven H; Department of Neurology, The Alfred Hospital, Melbourne, Australia.; Central Clinical School, Monash University, Melbourne, Australia.; Department of Neurology, Box Hill Hospital, Monash University, Melbourne, Australia., Kalincik T; CORe, Department of Medicine, University of Melbourne, L4 East, Grattan St, Melbourne, VIC, 3050, Australia. tomas.kalincik@unimelb.edu.au.; MS Centre, Department of Neurology, Royal Melbourne Hospital, Melbourne, Australia. tomas.kalincik@unimelb.edu.au.

Publikováno v: CNS drugs [CNS Drugs] 2021 Nov; Vol. 35 (11), pp. 1217-1232. Date of Electronic Publication: 2021 Sep 18.

Cortical N-acetyl aspartate is a predictor of long-term clinical disability in multiple sclerosis.

Autor: Wu X, Hanson LG, Skimminge A, Sorensen PS, Paulson OB, Mathiesen HK, Blinkenberg M

Publikováno v: Neurological research [Neurol Res] 2014 Aug; Vol. 36 (8), pp. 701-8. Date of Electronic Publication: 2014 Jan 21.