Zobrazeno 1 - 10
of 970
pro vyhledávání: '"Mathias V"'
Autor:
Shiladitya Mitra, Ghantasala S. Sameer Kumar, Anumita Samanta, Mathias V. Schmidt, Suman S. Thakur
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-10 (2024)
Abstract The Hypothalmic-Pituitary-Adrenal axis also known as the HPA axis is central to stress response. It also acts as the relay center between the body and the brain. We analysed hypothalamic proteome from mice subjected to chronic social defeat
Externí odkaz:
https://doaj.org/article/7b362935326f46899c4cd90536e5ccb2
Autor:
Jakob Hartmann, Thomas Bajaj, Joy Otten, Claudia Klengel, Tim Ebert, Anne-Kathrin Gellner, Ellen Junglas, Kathrin Hafner, Elmira A. Anderzhanova, Fiona Tang, Galen Missig, Lindsay Rexrode, Daniel T. Trussell, Katelyn X. Li, Max L. Pöhlmann, Sarah Mackert, Thomas M. Geiger, Daniel E. Heinz, Roy Lardenoije, Nina Dedic, Kenneth M. McCullough, Tomasz Próchnicki, Thomas Rhomberg, Silvia Martinelli, Antony Payton, Andrew C. Robinson, Valentin Stein, Eicke Latz, William A. Carlezon, Felix Hausch, Mathias V. Schmidt, Chris Murgatroyd, Sabina Berretta, Torsten Klengel, Harry Pantazopoulos, Kerry J. Ressler, Nils C. Gassen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract High levels of proinflammatory cytokines induce neurotoxicity and catalyze inflammation-driven neurodegeneration, but the specific release mechanisms from microglia remain elusive. Here we show that secretory autophagy (SA), a non-lytic moda
Externí odkaz:
https://doaj.org/article/83209dbad20940cdab3e3f6f4104353f
Autor:
Joeri Bordes, Lucas Miranda, Maya Reinhardt, Sowmya Narayan, Jakob Hartmann, Emily L. Newman, Lea Maria Brix, Lotte van Doeselaar, Clara Engelhardt, Larissa Dillmann, Shiladitya Mitra, Kerry J. Ressler, Benno Pütz, Felix Agakov, Bertram Müller-Myhsok, Mathias V. Schmidt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Severe stress exposure increases the risk of stress-related disorders such as major depressive disorder (MDD). An essential characteristic of MDD is the impairment of social functioning and lack of social motivation. Chronic social defeat st
Externí odkaz:
https://doaj.org/article/2d7b3209212947f594b741833990e1e5
Autor:
Saskia Wedel, Lisa Hahnefeld, Yannick Schreiber, Christian Namendorf, Tim Heymann, Manfred Uhr, Mathias V. Schmidt, Natasja de Bruin, Felix Hausch, Dominique Thomas, Gerd Geisslinger, Marco Sisignano
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-21 (2023)
Abstract Background Chemotherapy-induced neuropathic pain (CIPN) describes a pathological pain state that occurs dose-dependently as a side effect and can limit or even impede an effective cancer therapy. Unfortunately, current treatment possibilitie
Externí odkaz:
https://doaj.org/article/7393b95fee1a48c09212292b2adeaadf
Autor:
Elena Brivio, Aron Kos, Alessandro Francesco Ulivi, Stoyo Karamihalev, Andrea Ressle, Rainer Stoffel, Dana Hirsch, Gil Stelzer, Mathias V. Schmidt, Juan Pablo Lopez, Alon Chen
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112874- (2023)
Summary: Stress-related psychiatric disorders and the stress system show prominent differences between males and females, as well as strongly divergent transcriptional changes. Despite several proposed mechanisms, we still lack the understanding of t
Externí odkaz:
https://doaj.org/article/c83bb0bbab9c4a809d034d9340aeb3b0
Publikováno v:
Stress, Vol 26, Iss 1 (2023)
Stress is a normal response to situational pressures or demands. Exposure to stress activates the hypothalamic-pituitary-adrenal (HPA) axis and leads to the release of corticosteroids, which act in the brain via two distinct receptors: mineralocortic
Externí odkaz:
https://doaj.org/article/6f9345a1a6b04d99a40cfa887b90b50e
Autor:
Nathalie Gerstner, Anthi C. Krontira, Cristiana Cruceanu, Simone Roeh, Benno Pütz, Susann Sauer, Monika Rex-Haffner, Mathias V. Schmidt, Elisabeth B. Binder, Janine Knauer-Arloth
Publikováno v:
Neurobiology of Stress, Vol 21, Iss , Pp 100496- (2022)
Genome-wide gene expression analyses are invaluable tools for studying biological and disease processes, allowing a hypothesis-free comparison of expression profiles. Traditionally, transcriptomic analysis has focused on gene-level effects found by d
Externí odkaz:
https://doaj.org/article/54f05cebe8c844a4b4319b65530cf834
Autor:
Lea M. Brix, Irmak Toksöz, London Aman, Veronika Kovarova, Margherita Springer, Joeri Bordes, Lotte van Doeselaar, Clara Engelhardt, Alexander S. Häusl, Sowmya Narayan, Vera Sterlemann, Huanqing Yang, Jan M. Deussing, Mathias V. Schmidt
Publikováno v:
Molecular Metabolism, Vol 65, Iss , Pp 101579- (2022)
Objective: Steroidogenic factor 1 (SF1) expressing neurons in the ventromedial hypothalamus (VMH) have been directly implicated in whole-body metabolism and in the onset of obesity. The co-chaperone FKBP51 is abundantly expressed in the VMH and was r
Externí odkaz:
https://doaj.org/article/132b10c1b3664edd9b152209aa99d266
Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion
Autor:
Silvia Martinelli, Elmira A. Anderzhanova, Thomas Bajaj, Svenja Wiechmann, Frederik Dethloff, Katja Weckmann, Daniel E. Heinz, Tim Ebert, Jakob Hartmann, Thomas M. Geiger, Michael Döngi, Kathrin Hafner, Max L. Pöhlmann, Lee Jollans, Alexandra Philipsen, Susanne V. Schmidt, Ulrike Schmidt, Giuseppina Maccarrone, Valentin Stein, Felix Hausch, Christoph W. Turck, Mathias V. Schmidt, Anne-Kathrin Gellner, Bernhard Kuster, Nils C. Gassen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Glucocorticoids are associated with stress. Here, the authors show that high levels of glucocorticoid stress promote secretory autophagy of matrix metalloproteinase 9 via a stress responsive chaperone, increasing brain-derived neurotrophic factor pro
Externí odkaz:
https://doaj.org/article/4b82f8ddb5c141baac1137b7deee6057
Autor:
Chi Wang, Hui Liu, Kun Li, Zhen-Zhen Wu, Chen Wu, Jing-Ying Yu, Qian Gong, Ping Fang, Xing-Xing Wang, Shu-Min Duan, Hao Wang, Yan Gu, Ji Hu, Bing-Xing Pan, Mathias V. Schmidt, Yi-Jun Liu, Xiao-Dong Wang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Touch can positively modulate cognitive performance and emotional response. Here the authors demonstrate that enriched tactile experience improves memory and reduces anxiety in adult mice by remodelling the pathway from the primary somatosensory cort
Externí odkaz:
https://doaj.org/article/f4d3fbd4a0014022bbcfa204d1db18d2