Hydrogen Peroxide Induces α-Tubulin Detyrosination and Acetylation and Impacts Breast Cancer Metastatic Phenotypes.

Autor: Stemberger MB; Graduate Program in Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Greene St., Baltimore, MD 21201, USA., Ju JA; Graduate Program in Molecular Medicine, University of Maryland School of Medicine, 800 W. Baltimore St., Baltimore, MD 21201, USA., Thompson KN; Marlene and Stewart Greenebaum NCI Comprehensive Cancer Center, University of Maryland School of Medicine, 22 S. Greene St., Baltimore, MD 21201, USA., Mathias TJ; Graduate Program in Molecular Medicine, University of Maryland School of Medicine, 800 W. Baltimore St., Baltimore, MD 21201, USA., Jerrett AE; Marlene and Stewart Greenebaum NCI Comprehensive Cancer Center, University of Maryland School of Medicine, 22 S. Greene St., Baltimore, MD 21201, USA., Chang KT; Graduate Program in Molecular Medicine, University of Maryland School of Medicine, 800 W. Baltimore St., Baltimore, MD 21201, USA., Ory EC; Marlene and Stewart Greenebaum NCI Comprehensive Cancer Center, University of Maryland School of Medicine, 22 S. Greene St., Baltimore, MD 21201, USA., Annis DA; Graduate Program in Epidemiology and Human Genetics, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA., Mull ML; Graduate Program in Molecular Medicine, University of Maryland School of Medicine, 800 W. Baltimore St., Baltimore, MD 21201, USA., Gilchrist DE; Graduate Program in Molecular Medicine, University of Maryland School of Medicine, 800 W. Baltimore St., Baltimore, MD 21201, USA., Vitolo MI; Graduate Program in Molecular Medicine, University of Maryland School of Medicine, 800 W. Baltimore St., Baltimore, MD 21201, USA.; Marlene and Stewart Greenebaum NCI Comprehensive Cancer Center, University of Maryland School of Medicine, 22 S. Greene St., Baltimore, MD 21201, USA.; Departments of Pharmacology and Physiology, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA., Martin SS; Graduate Program in Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Greene St., Baltimore, MD 21201, USA.; Graduate Program in Molecular Medicine, University of Maryland School of Medicine, 800 W. Baltimore St., Baltimore, MD 21201, USA.; Marlene and Stewart Greenebaum NCI Comprehensive Cancer Center, University of Maryland School of Medicine, 22 S. Greene St., Baltimore, MD 21201, USA.; Graduate Program in Epidemiology and Human Genetics, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA.; Departments of Pharmacology and Physiology, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA.; United States Department of Veterans Affairs, VA Maryland Health Care System, 10 18 N. Greene St., Baltimore, MD 21201, USA.

Publikováno v: Cells [Cells] 2023 Apr 27; Vol. 12 (9). Date of Electronic Publication: 2023 Apr 27.

Model for Integration of Monogenic Diabetes Diagnosis Into Routine Care: The Personalized Diabetes Medicine Program.

Autor: Zhang H; Department of Endocrinology, Peking Union Medical College Hospital, Beijing, China.; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD., Kleinberger JW; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD., Maloney KA; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD., Guan Y; Rollins School of Public Health, Emory University, Atlanta, GA., Mathias TJ; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD., Bisordi K; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD., Streeten EA; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD., Blessing K; Geisinger Health System, Danville, PA., Snyder MN; Geisinger Health System, Danville, PA., Bromberger LA; Metabolism, Osteoporosis/Obesity, Diabetes, Endocrinology and Lipids (MODEL) Clinical Research, Research Division of Bay Endocrinology Associates, Baltimore, MD., Goehringer J; Geisinger Health System, Danville, PA., Kimball A; Harvey Institute for Human Genetics, Greater Baltimore Medical Center, Baltimore, MD., Damcott CM; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD., Taylor CO; Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD., Nicholson M; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD., Nwaba D; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD., Palmer K; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD., Sewell D; University of Maryland Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD., Ambulos N; University of Maryland Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD., Jeng LJB; Division of Rare Diseases and Medical Genetics, US Food and Drug Administration, Silver Spring, MD., Shuldiner AR; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD., Levin P; Bay West Endocrinology Associates, Baltimore, MD., Carey DJ; Geisinger Health System, Danville, PA., Pollin TI; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.

Publikováno v: Diabetes care [Diabetes Care] 2022 Aug 01; Vol. 45 (8), pp. 1799-1806.

Tubulin Carboxypeptidase Activity Promotes Focal Gelatin Degradation in Breast Tumor Cells and Induces Apoptosis in Breast Epithelial Cells That Is Overcome by Oncogenic Signaling.

Autor: Mathias TJ; Marlene and Stewart Greenebaum NCI Comprehensive Cancer Center, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA.; Graduate Program in Molecular Medicine, University of Maryland School of Medicine, 800 W. Baltimore St., Baltimore, MD 21201, USA.; Medical Scientist Training Program (MSTP), University of Maryland School of Medicine, 800 W. Baltimore St., Baltimore, MD 21201, USA., Ju JA; Marlene and Stewart Greenebaum NCI Comprehensive Cancer Center, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA.; Department of Pharmacology and Physiology, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA., Lee RM; Marlene and Stewart Greenebaum NCI Comprehensive Cancer Center, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA.; Department of Pharmacology and Physiology, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA., Thompson KN; Marlene and Stewart Greenebaum NCI Comprehensive Cancer Center, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA.; Department of Pharmacology and Physiology, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA., Mull ML; Marlene and Stewart Greenebaum NCI Comprehensive Cancer Center, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA.; Graduate Program in Molecular Medicine, University of Maryland School of Medicine, 800 W. Baltimore St., Baltimore, MD 21201, USA., Annis DA; Marlene and Stewart Greenebaum NCI Comprehensive Cancer Center, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA.; Graduate Program in Epidemiology and Human Genetics, University of Maryland School of Medicine, 800 W. Baltimore St., Baltimore, MD 21201, USA., Chang KT; Marlene and Stewart Greenebaum NCI Comprehensive Cancer Center, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA.; Graduate Program in Molecular Medicine, University of Maryland School of Medicine, 800 W. Baltimore St., Baltimore, MD 21201, USA., Ory EC; Marlene and Stewart Greenebaum NCI Comprehensive Cancer Center, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA.; Department of Pharmacology and Physiology, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA., Stemberger MB; Marlene and Stewart Greenebaum NCI Comprehensive Cancer Center, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA.; Graduate Program in Biochemistry & Molecular Biology, University of Maryland School of Medicine, 108 N. Greene St., Baltimore, MD 21201, USA., Hotta T; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA., Ohi R; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA., Vitolo MI; Marlene and Stewart Greenebaum NCI Comprehensive Cancer Center, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA.; Department of Pharmacology and Physiology, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA., Moutin MJ; Grenoble Institut Neurosciences, University Grenoble Alpes, Inserm, U1216, CEA, CNRS, 38000 Grenoble, France., Martin SS; Marlene and Stewart Greenebaum NCI Comprehensive Cancer Center, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA.; Department of Pharmacology and Physiology, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA.; United States Department of Veterans Affairs, VA Maryland Health Care System, Baltimore, MD 21201, USA.

Publikováno v: Cancers [Cancers (Basel)] 2022 Mar 28; Vol. 14 (7). Date of Electronic Publication: 2022 Mar 28.

Long Noncoding RNA DANCR Activates Wnt/β-Catenin Signaling through MiR-216a Inhibition in Non-Small Cell Lung Cancer.

Autor: Yu JE; Program in Molecular Medicine, University of Maryland Graduate Program in Life Sciences, Baltimore, MD 21201, USA., Ju JA; Marlene and Stewart Greenebaum NCI Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Musacchio N; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Mathias TJ; Program in Molecular Medicine, University of Maryland Graduate Program in Life Sciences, Baltimore, MD 21201, USA., Vitolo MI; Marlene and Stewart Greenebaum NCI Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA.; Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Publikováno v: Biomolecules [Biomolecules] 2020 Dec 08; Vol. 10 (12). Date of Electronic Publication: 2020 Dec 08.

Mechanoactivation of NOX2-generated ROS elicits persistent TRPM8 Ca ²⁺ signals that are inhibited by oncogenic KRas.

Autor: Pratt SJP; Program in Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, MD 21201; sjppratt@umaryland.edu ssmartin@som.umaryland.edu.; Department of Pharmacology, School of Medicine, University of Maryland, Baltimore, MD 21201.; Department of Physiology, School of Medicine, University of Maryland, Baltimore, MD 21201.; Marlene and Stewart Greenebaum National Cancer Institute Comprehensive Cancer Center, School of Medicine, University of Maryland, Baltimore, MD 21201., Lee RM; Department of Pharmacology, School of Medicine, University of Maryland, Baltimore, MD 21201.; Department of Physiology, School of Medicine, University of Maryland, Baltimore, MD 21201.; Marlene and Stewart Greenebaum National Cancer Institute Comprehensive Cancer Center, School of Medicine, University of Maryland, Baltimore, MD 21201., Chang KT; Department of Pharmacology, School of Medicine, University of Maryland, Baltimore, MD 21201.; Department of Physiology, School of Medicine, University of Maryland, Baltimore, MD 21201.; Marlene and Stewart Greenebaum National Cancer Institute Comprehensive Cancer Center, School of Medicine, University of Maryland, Baltimore, MD 21201., Hernández-Ochoa EO; Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, MD 21201., Annis DA; Department of Pharmacology, School of Medicine, University of Maryland, Baltimore, MD 21201.; Marlene and Stewart Greenebaum National Cancer Institute Comprehensive Cancer Center, School of Medicine, University of Maryland, Baltimore, MD 21201., Ory EC; Department of Pharmacology, School of Medicine, University of Maryland, Baltimore, MD 21201.; Department of Physiology, School of Medicine, University of Maryland, Baltimore, MD 21201.; Marlene and Stewart Greenebaum National Cancer Institute Comprehensive Cancer Center, School of Medicine, University of Maryland, Baltimore, MD 21201., Thompson KN; Department of Pharmacology, School of Medicine, University of Maryland, Baltimore, MD 21201.; Department of Physiology, School of Medicine, University of Maryland, Baltimore, MD 21201.; Marlene and Stewart Greenebaum National Cancer Institute Comprehensive Cancer Center, School of Medicine, University of Maryland, Baltimore, MD 21201., Bailey PC; Program in Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, MD 21201.; Department of Pharmacology, School of Medicine, University of Maryland, Baltimore, MD 21201.; Department of Physiology, School of Medicine, University of Maryland, Baltimore, MD 21201.; Marlene and Stewart Greenebaum National Cancer Institute Comprehensive Cancer Center, School of Medicine, University of Maryland, Baltimore, MD 21201., Mathias TJ; Department of Pharmacology, School of Medicine, University of Maryland, Baltimore, MD 21201.; Department of Physiology, School of Medicine, University of Maryland, Baltimore, MD 21201.; Marlene and Stewart Greenebaum National Cancer Institute Comprehensive Cancer Center, School of Medicine, University of Maryland, Baltimore, MD 21201., Ju JA; Department of Pharmacology, School of Medicine, University of Maryland, Baltimore, MD 21201.; Department of Physiology, School of Medicine, University of Maryland, Baltimore, MD 21201.; Marlene and Stewart Greenebaum National Cancer Institute Comprehensive Cancer Center, School of Medicine, University of Maryland, Baltimore, MD 21201., Vitolo MI; Department of Pharmacology, School of Medicine, University of Maryland, Baltimore, MD 21201.; Department of Physiology, School of Medicine, University of Maryland, Baltimore, MD 21201.; Marlene and Stewart Greenebaum National Cancer Institute Comprehensive Cancer Center, School of Medicine, University of Maryland, Baltimore, MD 21201., Schneider MF; Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, MD 21201., Stains JP; Department of Orthopaedics, School of Medicine, University of Maryland, Baltimore, MD 21201., Ward CW; Department of Orthopaedics, School of Medicine, University of Maryland, Baltimore, MD 21201.; School of Nursing, University of Maryland, Baltimore, MD 21201., Martin SS; Department of Pharmacology, School of Medicine, University of Maryland, Baltimore, MD 21201; sjppratt@umaryland.edu ssmartin@som.umaryland.edu.; Department of Physiology, School of Medicine, University of Maryland, Baltimore, MD 21201.; Marlene and Stewart Greenebaum National Cancer Institute Comprehensive Cancer Center, School of Medicine, University of Maryland, Baltimore, MD 21201.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Oct 20; Vol. 117 (42), pp. 26008-26019. Date of Electronic Publication: 2020 Oct 05.