Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mathias Schenk"'
Autor:
Nicole Bäumer, Annika Scheller, Lisa Wittmann, Andreas Faust, Mara Apel, Subbaiah Chary Nimmagadda, Christiane Geyer, Katharina Grunert, Neele Kellmann, Matthias Peipp, Sareetha Kailayangiri, Matias Ezequiel Gutierrez Suburu, Cristian A. Strassert, Mathias Schenk, Lilo Greune, Christian Rüter, Petra Dersch, Wolfgang Hartmann, Claudia Rossig, Dario Neri, Carsten Müller-Tidow, Christian Schwöppe, Christoph Schliemann, Cyrus Khandanpour, Georg Lenz, Wolfgang E. Berdel, Sebastian Bäumer
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-26 (2022)
Abstract Background Acute myeloid leukemia (AML) is a fatal clonal hematopoietic malignancy, which results from the accumulation of several genetic aberrations in myeloid progenitor cells, with a worldwide 5-year survival prognosis of about 30%. Ther
Externí odkaz:
https://doaj.org/article/522914dd6cf246468f2f5d959f5f9ca1
Autor:
Kathrin Gnoth, Anke Piechotta, Martin Kleinschmidt, Sandra Konrath, Mathias Schenk, Nadine Taudte, Daniel Ramsbeck, Vera Rieckmann, Stefanie Geissler, Rico Eichentopf, Susan Barendrecht, Maike Hartlage-Rübsamen, Hans-Ulrich Demuth, Steffen Roßner, Holger Cynis, Jens-Ulrich Rahfeld, Stephan Schilling
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-20 (2020)
Abstract Background Amyloid β (Aβ)-directed immunotherapy has shown promising results in preclinical and early clinical Alzheimer’s disease (AD) trials, but successful translation to late clinics has failed so far. Compelling evidence suggests th
Externí odkaz:
https://doaj.org/article/2c961e761ce84b74a60f7925a3750699
Autor:
Praveen Bathini, Tao Sun, Mathias Schenk, Stephan Schilling, Nathan J. McDannold, Cynthia A. Lemere
Publikováno v:
Biomolecules, Vol 12, Iss 7, p 951 (2022)
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid plaques and hyperphosphorylated tau in the brain. Currently, therapeutic agents targeting amyloid appear promising for AD, however, delivery to th
Externí odkaz:
https://doaj.org/article/b6aecf123a41413a84c77ded4f7c9733
Autor:
Torsten Hoffmann, Jens-Ulrich Rahfeld, Mathias Schenk, Falk Ponath, Koki Makioka, Birgit Hutter-Paier, Inge Lues, Cynthia A. Lemere, Stephan Schilling
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11791 (2021)
Compelling evidence suggests that pyroglutamate-modified Aβ (pGlu3-Aβ; AβN3pG) peptides play a pivotal role in the development and progression of Alzheimer’s disease (AD). Approaches targeting pGlu3-Aβ by glutaminyl cyclase (QC) inhibition (Var
Externí odkaz:
https://doaj.org/article/89c9c71cfc674b7a85f12930560acd52
Autor:
Torsten Hoffmann, Mathias Schenk, Kathrin Gnoth, Victoria Ilse, Daniela Brunner, Jens‐Ulrich Rahfeld, Stephan Schilling, Michael Schaeffer
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::830309f1b9d1038a7ee85c966e11a23e
https://doi.org/10.1002/alz.069050
https://doi.org/10.1002/alz.069050
Autor:
Praveen Bathini, Tao Sun, Qiaoqiao Shi, Yongzhi Zhang, Nadine Taudte, Mathias Schenk, Thore Hettmann, Stephan Schilling, Nathan McDannold, Cynthia A Lemere
Publikováno v:
Alzheimer's & Dementia. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85f42c5efb2fd17b846866826042117e
https://doi.org/10.1002/alz.058725
https://doi.org/10.1002/alz.058725
Autor:
Qiaoqiao Shi, Tao Sun, Yongzhi Zhang, Chanikarn Power, Camilla Hoesch, Shawna Antonelli, Maren K. Schroeder, Barbara J. Caldarone, Nadine Taudte, Mathias Schenk, Thore Hettmann, Stephan Schilling, Nathan J. McDannold, Cynthia A. Lemere
Pyroglutamate-3 amyloid-β (pGlu3 Aβ) is an N-terminally modified, toxic form of amyloid-β that is present in cerebral amyloid plaques and vascular deposits. Using the Fc-competent murine anti-pGlu3 Aβ monoclonal antibody (mAb), 07/2a, we present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bd07fbc6dd87e4dd38fa550336015da
https://doi.org/10.1101/2021.01.15.426806
https://doi.org/10.1101/2021.01.15.426806
Autor:
Chanikarn Power, Qiaoqiao Shi, Yongzhi Zhang, Camilla Hoesch, Shawna Antonelli, Stephan Schilling, Tao Sun, Cynthia A. Lemere, Maren K. Schroeder, Thore Hettmann, Barbara J. Caldarone, Nadine Taudte, Nathan McDannold, Mathias Schenk
Publikováno v:
J Control Release
Pyroglutamate-3 amyloid-β (pGlu3 Aβ) is an N-terminally modified, pathogenic form of amyloid-β that is present in cerebral amyloid plaques and vascular deposits. Here, for the first time, wee used focused ultrasound (FUS) with microbubbles to enha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e514f32241a3a463973af4fe3ba17c4
https://pubmed.ncbi.nlm.nih.gov/34186148
https://pubmed.ncbi.nlm.nih.gov/34186148
Autor:
Stephan Schilling, Jens-Ulrich Rahfeld, Birgit Hutter-Paier, Cynthia A. Lemere, Koki Makioka, Torsten Hoffmann, Falk Ponath, Mathias Schenk, Inge Lues
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11791, p 11791 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Compelling evidence suggests that pyroglutamate-modified Aβ (pGlu3-Aβ; AβN3pG) peptides play a pivotal role in the development and progression of Alzheimer’s disease (AD). Approaches targeting pGlu3-Aβ by glutaminyl cyclase (QC) inhibition (Var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615b33175f138d92c3cb295fd67db3fc
https://publica.fraunhofer.de/handle/publica/270938
https://publica.fraunhofer.de/handle/publica/270938
Autor:
Andreas Hartmann, Koushik Sreenivasa, Mathias Schenkel, Neharika Chamachi, Philipp Schake, Georg Krainer, Michael Schlierf
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Single-molecule FRET (smFRET) has become a versatile tool for probing the structure and functional dynamics of biomolecular systems, and is extensively used to address questions ranging from biomolecular folding to drug discovery. Confocal s
Externí odkaz:
https://doaj.org/article/d542ad7af121497796c786fb44eed64e