Výsledky vyhledávání - "Mathias Gruen"

Isotopic labeling of recombinant proteins expressed in the protozoan host Leishmania tarentolae

Autor: Mathias Gruen, Ion Cristian Cirstea, Reinhard Breitling, Tim Bergbrede, Kirill Alexandrov, Regina Pietrucha, Peter Bayer, Anca Niculae

Publikováno v: Protein Expression and Purification. 48:167-172

Isotope labeling of recombinant proteins is a prerequisite for application of nuclear magnetic resonance spectroscopy (NMR) for the characterization of the three-dimensional structures and dynamics of proteins. Overexpression of isotopically labeled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a59fb260a1300e3d494f55fed1c929
https://doi.org/10.1016/j.pep.2006.04.006

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Myosin Binding Protein C, a Phosphorylation-Dependent Force Regulator in Muscle That Controls the Attachment of Myosin Heads by Its Interaction With Myosin S2

Autor: Mathias Gruen, Mathias Gautel, Gudrun Kunst, Rainer H. Fink, Kai R. Kress, Dietmar Uttenweiler

Publikováno v: Circulation Research. 86:51-58

Abstract —Myosin binding protein C (MyBP-C) is one of the major sarcomeric proteins involved in the pathophysiology of familial hypertrophic cardiomyopathy (FHC). The cardiac isoform is tris -phosphorylated by cAMP-dependent protein kinase (cAPK) o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3127d8f39a68b4de281a65b51fc5d27a
https://doi.org/10.1161/01.res.86.1.51

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cAPK-phosphorylation controls the interaction of the regulatory domain of cardiac myosin binding protein C with myosin-S2 in an on-off fashion

Autor: Mathias Gruen, Heino Prinz, Mathias Gautel

Publikováno v: FEBS Letters. 453:254-259

Myosin binding protein C is a protein of the myosin filaments of striated muscle which is expressed in isoforms specific for cardiac and skeletal muscle. The cardiac isoform is phosphorylated rapidly upon adrenergic stimulation of myocardium by cAMP-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0023261221abb74ff9fa597e5860c50
https://doi.org/10.1016/s0014-5793(99)00727-9

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Synthesis of 2′-Iodo- and 2′-Bromo-ATP and GTP Analogues as Potential Phasing Tools for X-ray Crystallography

Autor: Roger S. Goody, Andrea Beste, Christoph Siethoff, Axel J. Scheidig, Mathias Gruen, Christian F. W. Becker

Publikováno v: Nucleosides and Nucleotides. 18:137-151

Ara-adenosine (adenine 9-β-D-arabinofuranoside) and ara-guanosine (guanine 9-β-D-arabinofuranoside) are converted into 2′ halogenated ATP and GTP analogues by triflation and subsequent inversion of configuration at C-2′. For the commercially un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed8737d9636939a8168f3695e657fbc8
https://doi.org/10.1080/07328319908045600

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Fluorescent nucleotides: a powerful toolbox for labeling of biological macromolecules

Autor: Mathias Gruen, Thomas Waldbach, Buerk Schaefer, Frank Bieber, Thomas Billert

Publikováno v: Collection Symposium Series.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b079469e637aa0a866080809950efdf
https://doi.org/10.1135/css201414180

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An in vivo selection system for homing endonuclease activity

Autor: Mathias Gruen, Kathy Chang, Irina Serbanescu, David R. Liu

Homing endonucleases are enzymes that catalyze the highly sequence-specific cleavage of DNA. We have developed an in vivo selection in Escherichia coli that links cell survival with homing endonuclease-mediated DNA cleavage activity and sequence spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2154c165bbb7a5573cff06fe4cf8777a
https://europepmc.org/articles/PMC101853/

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