Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mathias Färnegårdh"'
Autor:
Ulrica Westermark, Yumei Diao, Karl-Johan Fasth, Mathias Färnegårdh, Katarina Färnegårdh, Kristin Hammer, Fredrik Lehmann, Klara Acs, Stefan Svensson Gelius
Publikováno v:
Biochemical and Biophysical Research Communications. 656:122-130
Autor:
Martin Hegen, David C. Wood, Patrik Rhönnstad, Felix Vajdos, Atli Thorarensen, Mark E. Schnute, Timothy Braden, Kimberly Crouse, Maria Sjöberg, John I. Trujillo, Ravi G. Kurumbail, Bolette Husman, Konrad F. Koehler, Mattias Wennerstål, Tomas Bonn, Joakim Löfstedt, Eva Backström-Rydin, Bo Carlsson, Aron Sundell, Ming Z. Chen, Steven E. Heasley, John David Trzupek, Annika Goos-Nilsson, Carol A. Menard, Peter Harris, James R. Kiefer, Martin Bengtsson, Leon P. Collis, Michael J. Prinsen, Philippe Nuhant, Jennifer Alley, Scott A. Long, Alexander E. Hromockyj, Andrew C. Flick, Johnny Sandberg, Christoph W. Zapf, Edouard Zamaratski, Xiao Hu, Lee Napierata, Björn Kauppi, Nicole Caspers, Kimberly F. Fennell, Robert E. Kyne, Gabriel Berstein, Neelu Kaila, Lars Kruger, Wei Li, Li Xing, Ray Unwalla, Elisabet Kallin, Matthew J. Pelc, Susan Fish, James Robert Blinn, Hjalmar Gullberg, Marvin J. Meyers, Scot Richard Mente, Chulho Choi, Falgun Shah, Mathias Färnegårdh, Dean Messing, Peter G. Jones, Yajuan Zhao, Alexandria P. Taylor, Maria Sandström, Charles W. Bolten, Daniel Nöteberg, Robin A. Weinberg, Tomasz Janosik, John D. Knafels, Anna Wilhelmsson
Publikováno v:
Journal of medicinal chemistry. 61(23)
The nuclear hormone receptor retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) is a promising target for the treatment of autoimmune diseases. A small molecule, inverse agonist of the receptor is anticipated to reduce production
Autor:
Liang Chen, Ponnal Nambi, Qiang-Yuan Liu, Rayomand J Unwalla, Valerie Clerin, Michael D Basso, Mathias Färnegårdh, Irene Feingold, Dawn A. Savio, James Carl Keith, Christopher P. Miller, Jay Wrobel, Anita R Halpern, Farooq Azam, Anna Wilhelmsson, Annika Goos-Nilsson, Robert R. Singhaus, Christine Resmini, Christine Huselton, Baihua Hu, Michael D. Collini, Elaine M. Quinet, Tomas Bonn, Cristofer Enroth
Publikováno v:
Journal of Medicinal Chemistry. 49:6151-6154
A structure-based approach was used to optimize our new class of quinoline LXR modulators leading to phenyl acetic acid substituted quinolines 15 and 16. Both compounds displayed good binding affinity for LXRbeta and LXRalpha and were potent activato
Autor:
Harri Ahola, Jan Ljunggren, Jan-Åke Gustafsson, Tomas Bonn, Mathias Färnegårdh, Sherry Sun, Mats Carlquist, Anna Wilhelmsson
Publikováno v:
Journal of Biological Chemistry. 278:38821-38828
The structures of the liver X receptor LXRbeta (NR1H2) have been determined in complexes with two synthetic ligands, T0901317 and GW3965, to 2.1 and 2.4 A, respectively. Together with its isoform LXRalpha (NR1H3) it regulates target genes involved in
Autor:
Karin Calles, Steven W. Muchmore, Anna Karin Ramqvist, Mats Carlquist, Jie Yang, Maria Alarcon, Jan Carlstedt-Duke, Owe Engström, John M. Harlan, Jan-Åke Gustafsson, Susanne Thorell, Harri Ahola, Björn Kauppi, Jonathan Greer, Clarissa G. Jakob, Lars Öhman, Mathias Färnegårdh
Publikováno v:
Journal of Biological Chemistry. 278:22748-22754
Here we describe the three-dimensional crystal structures of human glucocorticoid receptor ligand-binding domain (GR-LBD) in complex with the antagonist RU-486 at 2.3 A resolution and with the agonist dexamethasone ligand together with a coactivator
Autor:
Anna Bäcksbro-Saeidi, Sandra Gordon, Peter Agback, Bo Carlsson, Konrad F. Koehler, Peter Brandt, Stefan Rehnmark, Theresa Apelqvist, Johan Malm, Mathias Färnegårdh, Gary J. Grover, William Nelson, Marlena Grynfarb
Publikováno v:
Journal of Medicinal Chemistry. 49:6635-6637
A new high-affinity thyroid hormone antagonist 6 with druglike properties was designed and synthesized. The compound behaved as an antagonist in a cell transactivation assay, and in a first in vivo experiment in rats.
Publikováno v:
Current medicinal chemistry. 16(25)
Thyroid hormone receptors (TRs) exert profound effects on development, metabolism, and multiple specific organ functions. Principally by regulating crucial genes in a variety of tissues, the thyroid hormones, 3,5,3'-triiodo-L-thyronine (L-T-3, 1) and
Autor:
Fletcher Horace, Elaine Quinet, John W. Ullrich, Mathias Färnegårdh, Annika Goos-Nilsson, Rayomand J. Unwalla, Ronald C. Bernotas, David H. Kaufman, Jay E. Wrobel, Anna Wilhelmsson, Ponnal Nambi, Robert R. Singhaus
Publikováno v:
Bioorganicmedicinal chemistry. 17(4)
A series of 4-(amido-biarylether)-quinolines was prepared as potential LXR agonists. Appropriate substitution with amide groups provided high affinity LXR ligands, some with excellent potency and efficacy in functional assays of LXR activity. Novel a
Autor:
Tomas Bonn, Michael Basso, Edward Martin Matelan, Shuguang Wang, Jay E. Wrobel, George P. Vlasuk, Christine Huselton, Anna Wilhelmsson, S. Marc Bowen, Robert John Steffan, Stephen J. Gardell, Elaine Quinet, Jason I. Reminick, Zamaratski Edouard, Annika Goos Nilsson, Tomas Hansson, Valerie Clerin, Mathias Färnegårdh, Rayomand J. Unwalla, Ronald L. Magolda, Ponnal Nambi, Mark J. Evans, Irene Feingold
Publikováno v:
Journal of medicinal chemistry. 51(22)
A series of substituted 2-benzyl-3-aryl-7-trifluoromethylindazoles were prepared as LXR modulators. These compounds were partial agonists in transactivation assays when compared to 1 (T0901317) and were slightly weaker with respect to potency and eff
Autor:
Liu Ye, Ana-Maria Garcia Collazo, Mathias Färnegårdh, Konrad F. Koehler, Karin Mellström, Johnny Sandberg, Harri Ahola, Bolette Husman, Johan Malm, Jan Ljunggren, Marlena Grynfarb, Neeraj Garg
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(5)
Based on the examination of the crystal structure of rat TRbeta complexed with 3,5,3'-triiodo-l-thyronine (2) a novel TRbeta-selective indole derivative 6b was prepared and tested in vitro. This compound was found to be 14 times selective for TRbeta