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Autor:
Bolette Husman, Yi-Lin Li, Konrad F. Koehler, Johan Malm, Ana Maria Garcia Collazo, Chris Litten, Mathias Färnegård, Neeraj Garg, Karin Mellström, Johnny Sandberg, Marlena Grynfarb
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(4)
Based on the examination of the X-ray crystallographic structures of the LBD of TRalpha and TRbeta in complex with KB-141 (2), a number of novel 4'-hydroxy bioisosteric thyromimetics were prepared. Optimal affinity and beta-selectivity (33 times), wa