Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Mathias Droescher"'
Autor:
Edward F. Greenberg, Martin J. Voorbach, Alexandra Smith, David R. Reuter, Yuchuan Zhuang, Ji-Quan Wang, Dustin W. Wooten, Elizabeth Asque, Min Hu, Carolin Hoft, Ryan Duggan, Matthew Townsend, Karin Orsi, Karen Dalecki, Willi Amberg, Lori Duggan, Heather Knight, Joseph S. Spina, Yupeng He, Kennan Marsh, Vivian Zhao, Suzanne Ybarra, Jennifer Mollon, Yuni Fang, Aparna Vasanthakumar, Susan Westmoreland, Mathias Droescher, Sjoerd J. Finnema, Hana Florian
Publikováno v:
Heliyon, Vol 10, Iss 16, Pp e36483- (2024)
Alzheimer's disease (AD) is the most common global dementia and is universally fatal. Most late-stage AD disease-modifying therapies are intravenous and target amyloid beta (Aβ), with only modest effects on disease progression: there remains a high
Externí odkaz:
https://doaj.org/article/503b4807cc8c4b5188138ba8175721c8
Autor:
Peer B. Jacobson, Robin Goody, Matthew Lawrence, Bernhard K. Mueller, Xiaomeng Zhang, Bradley A. Hooker, Kimberly Pfleeger, Adam Ziemann, Charles Locke, Quentin Barraud, Mathias Droescher, Joerg Bernhard, Andreas Popp, Preethne Boeser, Lili Huang, Jennifer Mollon, Yulia Mordashova, Yi-Fang Cui, John P. Savaryn, Christine Grinnell, Ingeborg Dreher, Michael Gold, Grégoire Courtine, Andrea Mothe, Charles H. Tator, James D. Guest
Publikováno v:
Neurobiology of Disease, Vol 155, Iss , Pp 105385- (2021)
Spinal cord injury (SCI) is a devastating condition characterized by loss of function, secondary to damaged spinal neurons, disrupted axonal connections, and myelin loss. Spontaneous recovery is limited, and there are no approved pharmaceutical treat
Externí odkaz:
https://doaj.org/article/8dc4097a8c454ae6bfbbc5ad5984d8ca
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-2 (2018)
Externí odkaz:
https://doaj.org/article/259b03bbbdba46f7963ffc5065027c06
Autor:
Elaine Smith, Ingeborg Dreher, Mathias Droescher, Bradley A Hooker, Jennifer Mollon, Xiaomeng Zhang, Peer B Jacobson
Publikováno v:
Stroke. 54
Introduction: Current acute interventions for ischemic stroke aim to restore perfusion of affected tissue. There is an unmet need for therapies that protect neurons from ischemic damage and/or enhance natural repair processes to restore function. In
Autor:
Olav M. Andersen, Nikolaj Bøgh, Anne M. Landau, Gro G. Pløen, Anne Mette G. Jensen, Giulia Monti, Benedicte P. Ulhøi, Jens R. Nyengaard, Kirsten R. Jacobsen, Margarita M. Jørgensen, Ida E. Holm, Marianne L. Kristensen, Aage Kristian O. Alstrup, Esben S.S. Hansen, Charlotte E. Teunissen, Laura Breidenbach, Mathias Droescher, Ying Liu, Hanne S. Pedersen, Henrik Callesen, Yonglun Luo, Lars Bolund, David J. Brooks, Christoffer Laustsen, Scott A. Small, Lars F. Mikkelsen, Charlotte B. Sørensen
Publikováno v:
Andersen, O M, Bøgh, N, Landau, A M, Pløen, G G, Jensen, A M G, Monti, G, Ulhøi, B P, Nyengaard, J R, Jacobsen, K R, Jørgensen, M M, Holm, I E, Kristensen, M L, Alstrup, A K O, Hansen, E S S, Teunissen, C E, Breidenbach, L, Droescher, M, Liu, Y, Pedersen, H S, Callesen, H, Luo, Y, Bolund, L, Brooks, D J, Laustsen, C, Small, S A, Mikkelsen, L F & Sørensen, C B 2022, ' A genetically modified minipig model for Alzheimer's disease with SORL1 haploinsufficiency ', Cell reports. Medicine, vol. 3, no. 9, 100740 . https://doi.org/10.1016/j.xcrm.2022.100740
Andersen, O M, Bøgh, N, Landau, A M, Pløen, G G, Jensen, A M G, Monti, G, Ulhøi, B P, Nyengaard, J R, Jacobsen, K R, Jørgensen, M M, Holm, I E, Kristensen, M L, Alstrup, A K O, Hansen, E S S, Teunissen, C E, Breidenbach, L, Droescher, M, Liu, Y, Pedersen, H S, Callesen, H, Luo, Y, Bolund, L, Brooks, D J, Laustsen, C, Small, S A, Mikkelsen, L F & Sørensen, C B 2022, ' A genetically modified minipig model for Alzheimer's disease with SORL1 haploinsufficiency ', Cell Reports Medicine, vol. 3, no. 9, 100740 . https://doi.org/10.1016/j.xcrm.2022.100740
Cell Reports Medicine, 3(9):100740. Cell Press
Andersen, O M, Bøgh, N, Landau, A M, Pløen, G G, Jensen, A M G, Monti, G, Ulhøi, B P, Nyengaard, J R, Jacobsen, K R, Jørgensen, M M, Holm, I E, Kristensen, M L, Alstrup, A K O, Hansen, E S S, Teunissen, C E, Breidenbach, L, Droescher, M, Liu, Y, Pedersen, H S, Callesen, H, Luo, Y, Bolund, L, Brooks, D J, Laustsen, C, Small, S A, Mikkelsen, L F & Sørensen, C B 2022, ' A genetically modified minipig model for Alzheimer's disease with SORL1 haploinsufficiency ', Cell Reports Medicine, vol. 3, no. 9, 100740 . https://doi.org/10.1016/j.xcrm.2022.100740
Cell Reports Medicine, 3(9):100740. Cell Press
The established causal genes in Alzheimer's disease (AD), APP, PSEN1, and PSEN2, are functionally characterized using biomarkers, capturing an in vivo profile reflecting the disease's initial preclinical phase. Mutations in SORL1, encoding the endoso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::692217e27d26c70f47e5caa412c77719
https://vbn.aau.dk/da/publications/871f36d7-57e4-414a-9919-50f1b6541ce5
https://vbn.aau.dk/da/publications/871f36d7-57e4-414a-9919-50f1b6541ce5
Autor:
Christoffer Laustsen, Anne M. Landau, Margarita Melnikova Joergensen, Marianne Lundsgaard Kristensen, Olav M. Andersen, Ida Elisabeth Holm, Lars Friis Mikkelsen, Nikolaj Boegh, Mathias Droescher, Giulia Monti, Hanne Skovsgaard Pedersen, Lars Bolund, Henrik Callesen, Benedicte Parm Ulhoei, Charlotte Brandt Soerensen, Kirsten Rosenmay Jacobsen, Scott A. Small, Laura Breidenbach, Anne Mette G. Jensen, Jens R. Nyengaard, Gro Grunnet Ploeen, Esben Søvsø Szocska Hansen, David J. Brooks, Ying Liu, Charlotte E. Teunissen, Yonglun Luo
The few established causal genes in Alzheimer’s disease (AD), mutations in APP and PSENs, have been functionally characterized using biomarkers, capturing an in vivo profile reflecting the disease’s initial preclinical phase. SORL1, a gene encodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f87bb3d517054a38de8863ae1ace630b
https://doi.org/10.1101/2021.07.13.452149
https://doi.org/10.1101/2021.07.13.452149
Autor:
Giulia Monti, Lars Friis Mikkelsen, Marianne Lundsgaard Kristensen, Kirsten R Jacobsen, Charlotte E. Teunissen, David J. Brooks, Lars Bolund, Anne M. Landau, Christoffer Laustsen, Scott A. Small, Yonglun Luo, Anne Mette G. Jensen, Laura Breidenbach, Gro Grunnet Pløen, Jens R. Nyengaard, Margarita Melnikova Jørgensen, Hanne Skovsgaard Pedersen, Esben Søvsø Szocska Hansen, Charlotte S. Sørensen, Nikolaj Bøgh, Ying Liu, Mathias Droescher, Henrik Callesen, Benedicte Parm Ulhøi, Ida Elisabeth Holm, Olav M. Andersen
Publikováno v:
SSRN Electronic Journal.
The few established causal genes in Alzheimer’s disease (AD), mutations in APP and PSENs, have been functionally characterized using biomarkers, capturing an in vivo profile reflecting the disease’s initial preclinical phase. SORL1, a gene encodi
Autor:
Päivi Sutinen, Susumu Y. Imanishi, Mathias Droescher, Viduth K. Chaugule, Jan Rettich, Kay Hofmann, Esen Dogan, Jorma J. Palvimo, Andrea Pichler, Nathalie Eisenhardt, Stefanie Koidl
Publikováno v:
Nature Structural and Molecular Biology. 22(12):959-967
SUMO chains act as stress-induced degradation tags or repair factor-recruiting signals at DNA lesions. Although E1 activating, E2 conjugating and E3 ligating enzymes efficiently assemble SUMO chains, specific chain-elongation mechanisms are unknown.
The biological effects of cytokines are mediated by STAT proteins, a family of dimeric transcription factors. In order to elicit transcriptional activity, the STATs require activation by phosphorylation of a single tyrosine residue. Our experiments r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31f4056a2e33ff869919d5dca9f46e8
https://europepmc.org/articles/PMC5473235/
https://europepmc.org/articles/PMC5473235/
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-2 (2018)
Nature Communications
Nature Communications
Despite the global impact of macrophage activation in vascular disease, the underlying mechanisms remain obscure. Here we show, with global proteomic analysis of macrophage cell lines treated with either IFNγ or IL-4, that PARP9 and PARP14 regulate