Targeting of the CD161 inhibitory receptor enhances T-cell-mediated immunity against hematological malignancies.

Autor: Alvarez Calderon F; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA.; Harvard Medical School, Boston, MA., Kang BH; Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Cambridge, MA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA., Kyrysyuk O; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA., Zheng S; Department of Genetics and Genomic Sciences, Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Wang H; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.; Department of Immunology, Harvard Medical School, Boston, MA., Mathewson ND; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.; Department of Immunology, Harvard Medical School, Boston, MA.; Department of Neurology, Brigham and Women's Hospital, Boston, MA., Luoma AM; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.; Department of Immunology, Harvard Medical School, Boston, MA., Ning X; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.; Department of Immunology, Harvard Medical School, Boston, MA., Pyrdol J; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA., Cao X; Department of Genetics and Genomic Sciences, Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Suvà ML; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Boston, MA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA., Yuan GC; Department of Genetics and Genomic Sciences, Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Wittrup KD; Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Cambridge, MA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA., Wucherpfennig KW; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.; Harvard Medical School, Boston, MA.; Department of Immunology, Harvard Medical School, Boston, MA.; Department of Neurology, Brigham and Women's Hospital, Boston, MA.

Publikováno v: Blood [Blood] 2024 Mar 21; Vol. 143 (12), pp. 1124-1138.

BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma.

Autor: Panditharatna E; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts., Marques JG; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts., Wang T; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts., Trissal MC; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts., Liu I; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts., Jiang L; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts., Beck A; Center for Neuropathology, Ludwig Maximilian University of Munich, Munich, Germany., Groves A; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts., Dharia NV; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts., Li D; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts., Hoffman SE; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts., Kugener G; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts., Shaw ML; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts., Mire HM; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts., Hack OA; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts., Dempster JM; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts., Lareau C; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts.; Department of Pathology, Stanford University, Stanford, California., Dai L; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts., Sigua LH; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts., Quezada MA; Department of Neurology, Stanford University School of Medicine, Stanford, California., Stanton AJ; Department of Neurosurgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Wyatt M; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts., Kalani Z; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts., Goodale A; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts., Vazquez F; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts., Piccioni F; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts.; Merck Research Laboratories, Cambridge, Massachusetts., Doench JG; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts., Root DE; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts., Anastas JN; Division of Newborn Medicine and Epigenetics Program, Department of Medicine, Boston Children's Hospital, Boston, Massachusetts.; Department of Neurosurgery and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas., Jones KL; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Conway AS; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts., Stopka S; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Regan MS; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Liang Y; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts., Seo HS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts., Song K; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts., Bashyal P; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts., Jerome WP; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts., Mathewson ND; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.; Department of Microbiology and Immunobiology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.; Department of Neurology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Dhe-Paganon S; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts., Suvà ML; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.; Klarman Cell Observatory, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts., Carcaboso AM; Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain., Lavarino C; Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain., Mora J; Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain., Nguyen QD; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Ligon KL; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts.; Department of Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Pathology, Boston Children's Hospital, Boston, Massachusetts.; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts., Shi Y; Division of Newborn Medicine and Epigenetics Program, Department of Medicine, Boston Children's Hospital, Boston, Massachusetts.; Ludwig Institute for Cancer Research, Oxford Branch, Oxford University, Oxford, United Kingdom., Agnihotri S; Department of Neurosurgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Agar NYR; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts.; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Stegmaier K; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts., Stiles CD; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts., Monje M; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California., Golub TR; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts., Qi J; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts., Filbin MG; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts.

Publikováno v: Cancer discovery [Cancer Discov] 2022 Dec 02; Vol. 12 (12), pp. 2880-2905.

Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.

Autor: Hara T; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Chanoch-Myers R; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 761001, Israel., Mathewson ND; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Cancer Immunology and Virology, Department of Microbiology and Immunobiology, Department of Neurology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA., Myskiw C; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Atta L; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA., Bussema L; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Eichhorn SW; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA; Department of Chemistry and Chemical Biology, Department of Physics, Harvard University, Cambridge, MA 02138, USA., Greenwald AC; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 761001, Israel., Kinker GS; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 761001, Israel; Department of Physiology, Institute of Bioscience, University of Sao Paulo, Sao Paulo, Brazil., Rodman C; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Gonzalez Castro LN; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Neurology and Center for Neuro-Oncology, Brigham and Women's - Dana-Farber Cancer Center and Harvard Medical School, Boston, MA 02115, USA., Wakimoto H; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Rozenblatt-Rosen O; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Zhuang X; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA; Department of Chemistry and Chemical Biology, Department of Physics, Harvard University, Cambridge, MA 02138, USA., Fan J; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA., Hunter T; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Verma IM; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Wucherpfennig KW; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Cancer Immunology and Virology, Department of Microbiology and Immunobiology, Department of Neurology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA., Regev A; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Department of Biology, MIT, Cambridge, MA 02139, USA., Suvà ML; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: suva.mario@mgh.harvard.edu., Tirosh I; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 761001, Israel. Electronic address: itayt@weizmann.ac.il.

Publikováno v: Cancer cell [Cancer Cell] 2021 Jun 14; Vol. 39 (6), pp. 779-792.e11. Date of Electronic Publication: 2021 Jun 03.

Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma.

Autor: Jerby-Arnon L; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Neftel C; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Institute of Pathology, Faculty of Biology and Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland., Shore ME; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Weisman HR; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Mathewson ND; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Immunology, Harvard Medical School, Boston, MA, USA.; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., McBride MJ; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA., Haas B; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Izar B; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Columbia Center for Translational Immunology, New York, NY, USA.; Columbia University Medical Center, Division of Hematology and Oncology, New York, NY, USA., Volorio A; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Boulay G; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Cironi L; Institute of Pathology, Faculty of Biology and Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland., Richman AR; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Broye LC; Institute of Pathology, Faculty of Biology and Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland., Gurski JM; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Luo CC; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Mylvaganam R; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Nguyen L; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Mei S; Laboratory for Systems Pharmacology, Harvard Medical School, Boston, MA, USA., Melms JC; Columbia Center for Translational Immunology, New York, NY, USA.; Columbia University Medical Center, Division of Hematology and Oncology, New York, NY, USA., Georgescu C; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Cohen O; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA., Buendia-Buendia JE; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA., Segerstolpe A; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Sud M; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Cuoco MS; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Bioinformatics and Systems Biology Graduate Program, University of California, San Diego, La Jolla, CA, USA., Labes D; Flow Cytometry Facility, Department of Biology and Medicine, University of Lausanne, Lausanne, Switzerland., Gritsch S; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Zollinger DR; NanoString Technologies, Seattle, WA, USA., Ortogero N; NanoString Technologies, Seattle, WA, USA., Beechem JM; NanoString Technologies, Seattle, WA, USA., Petur Nielsen G; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Chebib I; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Nguyen-Ngoc T; Department of Oncology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland., Montemurro M; Department of Oncology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland., Cote GM; Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital, Boston, MA, USA., Choy E; Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital, Boston, MA, USA., Letovanec I; Institute of Pathology, Faculty of Biology and Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland., Cherix S; Department of Orthopedics, Faculty of Biology and Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland., Wagle N; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA., Sorger PK; Laboratory for Systems Pharmacology, Harvard Medical School, Boston, MA, USA., Haynes AB; Department of Surgery, Massachusetts General Hospital, Boston, MA, USA., Mullen JT; Department of Surgery, Massachusetts General Hospital, Boston, MA, USA., Stamenkovic I; Institute of Pathology, Faculty of Biology and Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland., Rivera MN; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Kadoch C; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA., Wucherpfennig KW; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Immunology, Harvard Medical School, Boston, MA, USA., Rozenblatt-Rosen O; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Suvà ML; Broad Institute of Harvard and MIT, Cambridge, MA, USA. Suva.Mario@mgh.harvard.edu.; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA. Suva.Mario@mgh.harvard.edu.; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Suva.Mario@mgh.harvard.edu., Riggi N; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. nicolo.riggi@chuv.ch.; Institute of Pathology, Faculty of Biology and Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. nicolo.riggi@chuv.ch., Regev A; Broad Institute of Harvard and MIT, Cambridge, MA, USA. aregev@broadinstitute.org.; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA. aregev@broadinstitute.org.; Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Department of Biology, MIT, Cambridge, MA, USA. aregev@broadinstitute.org.; Genentech, South San Francisco, CA, USA. aregev@broadinstitute.org.

Publikováno v: Nature medicine [Nat Med] 2021 Feb; Vol. 27 (2), pp. 289-300. Date of Electronic Publication: 2021 Jan 25.

Distinct evolutionary paths in chronic lymphocytic leukemia during resistance to the graft-versus-leukemia effect.

Autor: Bachireddy P; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Ennis C; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Nguyen VN; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Gohil SH; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Academic Haematology, University College London, London WC1E 6BT, UK., Clement K; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA., Shukla SA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Forman J; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Barkas N; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Freeman S; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Bavli N; Division of Hematology and Oncology, UT Southwestern, Dallas, TX 75390, USA., Elagina L; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Leshchiner I; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Mohammad AW; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Mathewson ND; Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Keskin DB; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Rassenti LZ; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92037, USA., Kipps TJ; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92037, USA., Brown JR; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Getz G; Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA., Ho VT; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Gnirke A; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Neuberg D; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Soiffer RJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Ritz J; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Alyea EP; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Kharchenko PV; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.; Harvard Stem Cell Institute, Cambridge, MA 02138, USA., Wu CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. cwu@partners.org.; Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2020 Sep 16; Vol. 12 (561).