Výsledky vyhledávání - "Mathews Michael"

Akademický článek

John William Trevan’s concept of Median Lethal Dose (LD50/LC50) – more misused than used

Autor: Sadasivan Kalathil Pillai, Katsumi Kobayashi, Mathews Michael, Thomson Mathai, Bhavana Sivakumar, Parvathy Sadasivan

Publikováno v: Journal of Pre-Clinical and Clinical Research, Vol 15, Iss 3, Pp 137-141 (2021)

Introduction Median lethal dose (MLD) has been a controversial subject among biologists and animal ethicists since its inception in 1927 by Trevan. Toxicologists use MLD (LD50) as the first step to assess the toxicity of a substance. Animal ethicists

Externí odkaz: https://doaj.org/article/61bd9db9cd9442ecab086ced5539a264

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Akademický článek

Irreproducibility –The deadly sin of preclinical research in drug development

Autor: Sadasivan Kalathil Pillai, Katsumi Kobayashi, Mathews Michael, Meena Arumugam

Publikováno v: Journal of Pre-Clinical and Clinical Research, Vol 14, Iss 4, Pp 165-168 (2020)

Introduction In recent years the irreproducibility of preclinical studies has become a serious concern in drug developmental research. The findings of preclinical studies that cannot be reproduced are a drain on public resources and slow down the dru

Externí odkaz: https://doaj.org/article/3cf67d6b422047818856a4c0ce6b965d

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Akademický článek

Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A

Autor: Saxena Deepti, Palumbo Paul, Hanauske-Abel Hartmut M, Hoque Mainul, D'Alliessi Gandolfi Darlene, Park Myung, Pe'ery Tsafi, Mathews Michael B

Publikováno v: Retrovirology, Vol 6, Iss 1, p 90 (2009)

Abstract Background Eukaryotic translation initiation factor eIF5A has been implicated in HIV-1 replication. This protein contains the apparently unique amino acid hypusine that is formed by the post-translational modification of a lysine residue cat

Externí odkaz: https://doaj.org/article/d146472d3ad64bf6bcac263c5c390d57

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