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Single cell T cell landscape and T cell receptor repertoire profiling of AML in context of PD-1 blockade therapy.

Autor: Abbas HA; Division of Cancer Medicine, Medical Oncology Fellowship, University of Texas M D Anderson Cancer Center, Houston, TX, USA.; Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hao D; Division of Cancer Medicine, Medical Oncology Fellowship, University of Texas M D Anderson Cancer Center, Houston, TX, USA.; Department of Genomic Medicine, University of Texas M D Anderson Cancer Center, Houston, TX, USA., Tomczak K; Department of Genomic Medicine, University of Texas M D Anderson Cancer Center, Houston, TX, USA., Barrodia P; Department of Genomic Medicine, University of Texas M D Anderson Cancer Center, Houston, TX, USA., Im JS; Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Reville PK; Division of Cancer Medicine, Medical Oncology Fellowship, University of Texas M D Anderson Cancer Center, Houston, TX, USA., Alaniz Z; Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wang W; Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wang R; Department of Genomic Medicine, University of Texas M D Anderson Cancer Center, Houston, TX, USA., Wang F; Department of Genomic Medicine, University of Texas M D Anderson Cancer Center, Houston, TX, USA., Al-Atrash G; Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Takahashi K; Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Genomic Medicine, University of Texas M D Anderson Cancer Center, Houston, TX, USA., Ning J; Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ding M; Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Statistics, Rice University, Houston, TX, USA., Beird HC; Department of Genomic Medicine, University of Texas M D Anderson Cancer Center, Houston, TX, USA., Mathews JT; Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Little L; Department of Genomic Medicine, University of Texas M D Anderson Cancer Center, Houston, TX, USA., Zhang J; Department of Genomic Medicine, University of Texas M D Anderson Cancer Center, Houston, TX, USA., Basu S; Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Konopleva M; Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Marques-Piubelli ML; Department Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Solis LM; Department Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Parra ER; Department Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lu W; Department Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Tamegnon A; Department Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Garcia-Manero G; Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Green MR; Department of Genomic Medicine, University of Texas M D Anderson Cancer Center, Houston, TX, USA.; Department of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Sharma P; Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Allison JP; Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kornblau SM; Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Rai K; Department of Genomic Medicine, University of Texas M D Anderson Cancer Center, Houston, TX, USA. KRai@mdanderson.org., Wang L; Department of Genomic Medicine, University of Texas M D Anderson Cancer Center, Houston, TX, USA. lwang22@mdanderson.org.; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. lwang22@mdanderson.org., Daver N; Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA. NDaver@mdanderson.org., Futreal A; Department of Genomic Medicine, University of Texas M D Anderson Cancer Center, Houston, TX, USA. AFutreal@mdanderson.org.; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. AFutreal@mdanderson.org.

Publikováno v: Nature communications [Nat Commun] 2021 Oct 18; Vol. 12 (1), pp. 6071. Date of Electronic Publication: 2021 Oct 18.