Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Mathew T. Pletcher"'
Autor:
Michelle L, Krishnan, Elizabeth, Berry-Kravis, Jamie K, Capal, Randall, Carpenter, Paul, Gringras, Joerg F, Hipp, Meghan T, Miller, Ana, Mingorance, Benjamin D, Philpot, Mathew T, Pletcher, Alexander, Rotenberg, Jorrit, Tjeertes, Paul P, Wang, Tom, Willgoss, Marie-Claire, de Wit, Shafali S, Jeste
Publikováno v:
Nature reviews. Drug discovery. 20(9)
Autor:
Kazuhiro Shimomura, Vivek Kumar, Nobuya Koike, Tae-Kyung Kim, Jason Chong, Ethan D Buhr, Andrew R Whiteley, Sharon S Low, Chiaki Omura, Deborah Fenner, Joseph R Owens, Marc Richards, Seung-Hee Yoo, Hee-Kyung Hong, Martha H Vitaterna, Joseph Bass, Mathew T Pletcher, Tim Wiltshire, John Hogenesch, Phillip L Lowrey, Joseph S Takahashi
Publikováno v:
eLife, Vol 2 (2013)
Genetic and molecular approaches have been critical for elucidating the mechanism of the mammalian circadian clock. Here, we demonstrate that the ClockΔ19 mutant behavioral phenotype is significantly modified by mouse strain genetic background. We m
Externí odkaz:
https://doaj.org/article/d769ffe1cd9845f0911f69fd98294374
Autor:
Shafali S. Jeste, Jorrit Tjeertes, Marie-Claire de Wit, Michelle L. Krishnan, Joerg F. Hipp, Benjamin D. Philpot, Jamie K. Capal, Mathew T. Pletcher, Elizabeth Berry-Kravis, Randall L. Carpenter, Ana Mingorance, Paul P. Wang, Alexander Rotenberg, Paul Gringras, T.G. Willgoss, Meghan T. Miller
Publikováno v:
Nature Reviews Drug Discovery. 20:653-654
Novel clinical evaluation strategies are needed to fulfil the potential of targeted therapies for rare neurodevelopmental disorders. Novel clinical evaluation strategies are needed to fulfil the potential of targeted therapies for rare neurodevelopme
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14458 (2010)
Animal models of human behavioral endophenotypes, such as the Tail Suspension Test (TST) and the Open Field assay (OF), have proven to be essential tools in revealing the genetics and mechanisms of psychiatric diseases. As in the human disorders they
Externí odkaz:
https://doaj.org/article/a566aa5fa5ad45de8ba24e912b5c36dd
Autor:
Salvatore Loguercio, Rupert W Overall, Jacob J Michaelson, Tim Wiltshire, Mathew T Pletcher, Brooke H Miller, John R Walker, Gerd Kempermann, Andrew I Su, Andreas Beyer
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e13920 (2010)
The study of expression quantitative trait loci (eQTL) is a powerful way of detecting transcriptional regulators at a genomic scale and for elucidating how natural genetic variation impacts gene expression. Power and genetic resolution are heavily af
Externí odkaz:
https://doaj.org/article/e1e6da615c0c494e9bd37ca5ba88ea12
Autor:
Mathew T Pletcher, Philip McClurg, Serge Batalov, Andrew I Su, S Whitney Barnes, Erica Lagler, Ron Korstanje, Xiaosong Wang, Deborah Nusskern, Molly A Bogue, Richard J Mural, Beverly Paigen, Tim Wiltshire
Publikováno v:
PLoS Biology, Vol 2, Iss 12, p e393 (2004)
Rapid expansion of available data, both phenotypic and genotypic, for multiple strains of mice has enabled the development of new methods to interrogate the mouse genome for functional genetic perturbations. In silico mapping provides an expedient wa
Externí odkaz:
https://doaj.org/article/efef8b3614124792a4afbd6699289005
Autor:
Erik C. Hett, Parag Sahasrabudhe, Mathew T. Pletcher, R. Aldrin Denny, Alexandria P. Taylor, Shenping Liu, Arindrajit Basak, Andrew C. Flick, Paul D. Bonin, Eugene Lvovich Piatnitski Chekler, Ingrid A. Stock, Lyn H. Jones, Shores C. Salter, Kieran F. Geoghegan
Publikováno v:
MedChemComm. 6:1018-1023
Medicinal chemistry techniques, including structure-based molecular design, fragment replacement and synthetic library enablement, were used to create potent inhibitors of bromodomain and extraterminal domain (BET) and CREB bindingprotein bromodomain
Autor:
Christian R. Marshall, Annette Estes, John Wei, Janet A. Buchanan, Jennifer L. Howe, Christina Chrysler, Weili Li, Tara Paton, Fiona Tsoi, Zhuozhi Wang, Brendan J. Frey, Eric Deneault, Edwin H. Cook, William Van Etten, Stephen W. Scherer, Mohammed Uddin, Mayada Elsabbagh, Emily Kirby, Sylvia Lamoureux, Cheryl Cytrynbaum, Bhooma Thiruvahindrapuram, Mathew T. Pletcher, Lonnie Zwaigenbaum, Wilson W L Sung, Angie Fedele, Daniele Merico, Bartha Maria Knoppers, Ryan K. C. Yuen, Marc Woodbury-Smith, Worrawat Engchuan, Vicki Seifer, Isabel M. Smith, Barbara Kellam, Bonnie Mackinnon Modi, Stephanie Koyanagi, Bridget A. Fernandez, James T. Robinson, Karen Ho, Edward J Higginbotham, Joe Whitney, Krissy A.R. Doyle-Thomas, Beth A. Malow, Susan Walker, Jeremy R. Parr, Louise Gallagher, Rob Nicolson, Jonathan Bingham, Thomas Nalpathamkalam, Lia D’Abate, Sanne Jilderda, Matt Bookman, Jessica Brian, Sarah J. Spence, Ann Thompson, Jonathan Leef, Rosanna Weksberg, Jacob A. S. Vorstman, Tal Savion-Lemieux, Anne Marie Tassé, Peter Szatmari, Alana Iaboni, Xudong Liu, Evdokia Anagnostou, Jeffrey R. MacDonald, Ny Hoang, Mehdi Zarrei, Lizhen Xu, Simon N. Twigger, Robert H. Ring, Stephen R. Dager, Melissa T. Carter, Irene Drmic, Michael J. Szego, Wendy Roberts, Lili Senman, Giovanna Pellecchia, Rohan V. Patel, Sergio L. Pereira, Joachim Hallmayer, David Glazer, Lisa J. Strug, Ada J.S. Chan, Nicole A. Deflaux
Publikováno v:
Nature Neuroscience, 20(4), 602. Nature Publishing Group
Paediatrics Publications
Paediatrics Publications
We are performing whole genome sequencing (WGS) of families with Autism Spectrum Disorder (ASD) to build a resource, named MSSNG, to enable the sub-categorization of phenotypes and underlying genetic factors involved. Here, we report WGS of 5,205 sam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b63f8e721122ea3d6acab7f7535d5d8f
https://europepmc.org/articles/PMC5501701/
https://europepmc.org/articles/PMC5501701/
Autor:
Carl Morris, Lauren D. Wood, Mathew T. Pletcher, Lyn H. Jones, Fan Zhang, Eric T. Wang, Nicole E. Bodycombe, Yumei L. Sun, Keith M. Haskell
Publikováno v:
Human Molecular Genetics
Myotonic dystrophy Type 1 (DM1) is a rare genetic disease caused by the expansion of CTG trinucleotide repeats ((CTG)exp) in the 3' untranslated region of the DMPK gene. The repeat transcripts sequester the RNA binding protein Muscleblind-like protei
Autor:
Amy H. Yang, Prashant R. Nambiar, Robert E. Chapin, Paul Butler, Mathew T. Pletcher, Brett D. Hollingshead, Karen Leach, Michael P. Lawton
Publikováno v:
Epigenetics for Drug Discovery ISBN: 9781849738828
Epigenetic mechanisms have emerged as attractive therapeutic targets because of their pleiotropic role in diseases processes and the ability to pharmacologically modulate their activities. One key question in the safety assessment of epigenetic drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19aca5768438c022dba75b930160638f
https://doi.org/10.1039/9781782628484-00288
https://doi.org/10.1039/9781782628484-00288