Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mathew Sebastiao"'
Publikováno v:
Bio-Protocol, Vol 13, Iss 19 (2023)
Disruptions and perturbations of the cellular plasma membrane by peptides have garnered significant interest in the elucidation of biological phenomena. Typically, these complex processes are studied using liposomes as model membranes—either by enc
Externí odkaz:
https://doaj.org/article/e7184de4b7e440919151dce04c86b46e
Autor:
Phuong Trang Nguyen, Ximena Zottig, Mathew Sebastiao, Alexandre A. Arnold, Isabelle Marcotte, Steve Bourgault
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Nguyen et al identified cytotoxic amyloid fibrils with oligomer-like characteristics, which were assembled from an islet amyloid polypeptide (IAPP) derivative containing an Asn-to-Gln substitution (N21Q). They presented evidence to show that these st
Externí odkaz:
https://doaj.org/article/28feaf14cc72438f8c537516bcfa2027
Autor:
Mathew, Sebastiao, Margaryta, Babych, Noé, Quittot, Kiran, Kumar, Alexandre A, Arnold, Isabelle, Marcotte, Steve, Bourgault
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1865:184118
Numerous pathophysiological conditions are associated with the misfolding and aggregation of proteins into insoluble amyloid fibrils. The mechanisms by which this process leads to cellular dysfunction remain elusive, though several hypotheses point t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6268a1907debf61b767c2f293184e6d
https://doi.org/10.1016/j.bbamem.2022.184118
https://doi.org/10.1016/j.bbamem.2022.184118
Autor:
Kiran Kumar, Mathew Sebastiao, Alexandre A. Arnold, Steve Bourgault, Dror E. Warschawski, Isabelle Marcotte
Publikováno v:
Biophys J
Biophysical Journal
Biophysical Journal, 2022, 121 (8), pp.1512-1524. ⟨10.1016/j.bpj.2022.03.009⟩
Biophysical Journal
Biophysical Journal, 2022, 121 (8), pp.1512-1524. ⟨10.1016/j.bpj.2022.03.009⟩
International audience; Antimicrobial peptides are promising therapeutic agents to mitigate the global rise of antibiotic resistance. They generally act by perturbing the bacterial cell membrane and are thus less likely to induce resistance. Because
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8516d61534607fc2b8bd274e079e0ec
https://europepmc.org/articles/PMC9072582/
https://europepmc.org/articles/PMC9072582/
Publikováno v:
Biochemistry. 58:1214-1225
Amyloids are polypeptide supramolecular assemblies that have been historically associated with numerous pathologies. Nonetheless, recent studies have identified many amyloid structures that accomplish vital physiological functions. Interestingly, amy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::752b4b61a6f2043378788e273a5293d6
https://doi.org/10.1021/acs.biochem.8b01206
https://doi.org/10.1021/acs.biochem.8b01206
Autor:
Mathew Sebastiao, Steve Bourgault, Alexandre A. Arnold, Ximena Zottig, Isabelle Marcotte, Phuong Trang Nguyen
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Protein misfolding and amyloid deposition are associated with numerous diseases. The detailed characterization of the proteospecies mediating cell death remains elusive owing to the (supra)structural polymorphism and transient nature of the assemblie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08cf1794034b37aa2beaf12d201e0da7
https://pubmed.ncbi.nlm.nih.gov/34354242
https://pubmed.ncbi.nlm.nih.gov/34354242
Autor:
Phuong Trang Nguyen, Margaryta Babych, Steve Bourgault, Noé Quittot, Mathilde Fortier, Mathew Sebastiao
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 35(2)
Glycosaminoglycans (GAGs) are long and unbranched anionic heteropolysaccharides that have been associated with virtually all amyloid deposits. Soluble sulfated GAGs are known for their propensity to promote the self-assembly of numerous amyloidogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d5712724718f6c2c1031d0eeec587d
https://pubmed.ncbi.nlm.nih.gov/33475205
https://pubmed.ncbi.nlm.nih.gov/33475205
Publikováno v:
Biochemistry. 56:3808-3817
Deamidation of an asparagine residue is a spontaneous non-enzymatic post-translational modification that results in the conversion of asparagine into a mixture of aspartic acid and isoaspartic acid. This chemical conversion modulates protein conforma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::452763c3266503ec1ca7fe5132239c06
https://doi.org/10.1021/acs.biochem.7b00209
https://doi.org/10.1021/acs.biochem.7b00209
Publikováno v:
Analytical biochemistry. 532
The most frequent method to monitor amyloid formation relies on the fluorescence of thioflavin T (ThT). The present study reports a novel factor of irreproducibility in ThT kinetic assays performed in microplate. Discrepancies among kinetics of amylo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::731dfd6c7b9fa6150b434f737bc1814d
https://pubmed.ncbi.nlm.nih.gov/28623075
https://pubmed.ncbi.nlm.nih.gov/28623075
Publikováno v:
Biochemistry and cell biology = Biochimie et biologie cellulaire. 95(3)
Glycosaminoglycans (GAGs) are long and unbranched polysaccharides that are abundant in the extracellular matrix and basement membrane of multicellular organisms. These linear polyanionic macromolecules are involved in many physiological functions fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a550a91d22cfa18e94d7fba4240892
https://pubmed.ncbi.nlm.nih.gov/28177755
https://pubmed.ncbi.nlm.nih.gov/28177755