Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Mathew P, Martin"'
Autor:
Faiz M Kassim, J H Mark Lim, Sophie V Slawik, Katharina Gaus, Benjamin Peters, Joseph W Y Lee, Emily K Hepple, Jennifer Rodger, Matthew A Albrecht, Mathew T Martin-Iverson
Publikováno v:
PLoS ONE, Vol 18, Iss 7, p e0287538 (2023)
Studies that examined the effect of amphetamine or caffeine on spatial working memory (SWM) and verbal working memory (VWM) have used various tasks. However, there are no studies that have used spatial span tasks (SSTs) to assess the SWM effect of am
Externí odkaz:
https://doaj.org/article/92aa1f5c7e7542568e0fe00d29661f62
Autor:
Alice Douangamath, Daren Fearon, Paul Gehrtz, Tobias Krojer, Petra Lukacik, C. David Owen, Efrat Resnick, Claire Strain-Damerell, Anthony Aimon, Péter Ábrányi-Balogh, José Brandão-Neto, Anna Carbery, Gemma Davison, Alexandre Dias, Thomas D. Downes, Louise Dunnett, Michael Fairhead, James D. Firth, S. Paul Jones, Aaron Keeley, György M. Keserü, Hanna F. Klein, Mathew P. Martin, Martin E. M. Noble, Peter O’Brien, Ailsa Powell, Rambabu N. Reddi, Rachael Skyner, Matthew Snee, Michael J. Waring, Conor Wild, Nir London, Frank von Delft, Martin A. Walsh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The SARS-CoV-2 main protease is an important target for the development of COVID-19 therapeutics. Here, the authors combine X-ray crystallography and mass spectrometry and performed a large scale fragment screening campaign, which yielded 96 liganded
Externí odkaz:
https://doaj.org/article/d499338758524d99942f9963faf75661
Autor:
Duncan C. Miller, Suzannah J. Harnor, Mathew P. Martin, Richard A. Noble, Stephen R. Wedge, Celine Cano
Publikováno v:
Journal of Medicinal Chemistry. 66:4491-4502
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c286d0f072a149458bea662b0d7df668
https://doi.org/10.1021/acs.jmedchem.3c00072
https://doi.org/10.1021/acs.jmedchem.3c00072
Autor:
Steven R. Whittaker, Clare Barlow, Mathew P. Martin, Caterina Mancusi, Steve Wagner, Annette Self, Elaine Barrie, Robert Te Poele, Swee Sharp, Nathan Brown, Stuart Wilson, Wayne Jackson, Peter M. Fischer, Paul A. Clarke, Michael I. Walton, Edward McDonald, Julian Blagg, Martin Noble, Michelle D. Garrett, Paul Workman
Publikováno v:
Molecular Oncology, Vol 12, Iss 3, Pp 287-304 (2018)
Deregulation of the cyclin‐dependent kinases (CDKs) has been implicated in the pathogenesis of multiple cancer types. Consequently, CDKs have garnered intense interest as therapeutic targets for the treatment of cancer. We describe herein the molec
Externí odkaz:
https://doaj.org/article/fe1e3db27bb44f2e82c1a7b2ffc32006
Autor:
Gemma Davison, Mathew P. Martin, Shannon Turberville, Selma Dormen, Richard Heath, Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sanderson, Ian Hope, Daniel J. Wood, Céline Cano, Jane A. Endicott, Ian R. Hardcastle, Martin E. M. Noble, Michael J. Waring
Publikováno v:
Journal of Medicinal Chemistry. 65:15416-15432
The development of ligands for biological targets is critically dependent on the identification of sites on proteins that bind molecules with high affinity. A set of compounds, called FragLites, can identify such sites, along with the interactions re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f5f45f4a2b13dc353a06e52583b772
https://doi.org/10.1021/acs.jmedchem.2c01357
https://doi.org/10.1021/acs.jmedchem.2c01357
Autor:
Julie A. Tucker, Mathew P. Martin
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7560 (2021)
This special issue on Advances in Kinase Drug Discovery provides a selection of research articles and topical reviews covering all aspects of drug discovery targeting the phosphotransferase enzyme family [...]
Externí odkaz:
https://doaj.org/article/7473fe91d35b4a74a1e3e29e2e686ce8
Autor:
Mélanie Uguen, Gemma Davison, Lukas J. Sprenger, James H. Hunter, Mathew P. Martin, Shannon Turberville, Jessica E. Watt, Bernard T. Golding, Martin E. M. Noble, Hannah L. Stewart, Michael J. Waring
Publikováno v:
Journal of Medicinal Chemistry. 65:11322-11339
High-throughput screening provides one of the most common ways of finding hit compounds. Lead-like libraries, in particular, provide hits with compatible functional groups and vectors for structural elaboration and physical properties suitable for op
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6256166e5479fe951e145b5d73e9a32f
https://doi.org/10.1021/acs.jmedchem.2c00897
https://doi.org/10.1021/acs.jmedchem.2c00897
Autor:
Saïd M. Sebti, Nicholas J. Lawrence, Ernst Schönbrunn, Mathew P. Martin, Nan Sun, Ying Sun, Roberta Pireddu, Kara D. Forinash, Ronil A. Patel
PDF file, 58K, Percent tumor volume change after mouse treatment with vehicle. ErbB2 mammary tumor transgenic mice were treated with Vehicle (20% HPCD) as described under Materials and Methods. Percent change in tumor volume was calculated for each t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010cd8795a78124402a30c017fde77c6
https://doi.org/10.1158/0008-5472.22395765
https://doi.org/10.1158/0008-5472.22395765
Autor:
Saïd M. Sebti, Nicholas J. Lawrence, Ernst Schönbrunn, Mathew P. Martin, Nan Sun, Ying Sun, Roberta Pireddu, Kara D. Forinash, Ronil A. Patel
PDF file, 56K, Percent mouse weight change after vehicle treatment. ErbB2 mammary tumor transgenic mice were treated with Vehicle (20% HPCD) as described under Materials and Methods. Final percent change in weight was calculated for each mouse using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b036d791eed5cc9092b87753bb1603
https://doi.org/10.1158/0008-5472.22395759.v1
https://doi.org/10.1158/0008-5472.22395759.v1
Autor:
Saïd M. Sebti, Nicholas J. Lawrence, Ernst Schönbrunn, Mathew P. Martin, Nan Sun, Ying Sun, Roberta Pireddu, Kara D. Forinash, Ronil A. Patel
PDF file, 59K, Percent mouse weight change after RKI-1447 treatment. ErbB2 mammary tumor transgenic mice were treated with RKI-1447 as described under Materials and Methods. Final percent change in weight was calculated for each mouse using the follo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0b7387632b7e2eb8ac99e920405251
https://doi.org/10.1158/0008-5472.22395762.v1
https://doi.org/10.1158/0008-5472.22395762.v1