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Outcome measures from experimental traumatic brain injury in male rats vary with the complete temporal biomechanical profile of the injury event

Autor: Bryan J. Pfister, Mathew Long, Rafael Ordaz, Radia Abdul-Wahab, Bruce G. Lyeth

Publikováno v: Journal of Neuroscience Research. 98:2027-2044

Millions suffer a traumatic brain injury (TBI) each year wherein the outcomes associated with injury can vary greatly between individuals. This study postulates that variations in each biomechanical parameter of a head trauma lead to differences in h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016d7cbd2f8bd0c1c71624af63b4bf4d
https://doi.org/10.1002/jnr.24670

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Long-Lasting Suppression of Acoustic Startle Response after Mild Traumatic Brain Injury

Autor: Vijayalakshmi Santhakumar, Jessica J. Roland, Richard J. Servatius, Kevin C.H. Pang, Neil Nadpara, Swamini Sinha, Mathew Long, Bryan J. Pfister, Pelin Avcu

Publikováno v: Journal of Neurotrauma. 32:801-810

Acoustic startle response (ASR) is a defensive reflex that is largely ignored unless greatly exaggerated. ASR is suppressed after moderate and severe traumatic brain injury (TBI), but the effect of mild TBI (mTBI) on ASR has not been investigated. Be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea8bdbb7a483e74f4432c2d377391447
https://doi.org/10.1089/neu.2014.3451

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RELATIVELY FAST GROWTH AND MODERATE LONGEVITY FOR THE ANTARCTIC SCALLOP, ADAMUSSIUM COLBECKI, LIVING IN THE COLDEST WATERS ON EARTH

Autor: Roger Mann, Sally E. Walker, Samuel S. Bowser, Mathew Long, Kelly E. Cronin, A.S. Chute

Publikováno v: Geological Society of America Abstracts with Programs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9db32f0c0c503544dfbffbb373d16a59
https://doi.org/10.1130/abs/2017am-306175

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Traumatic brain injury induced matrix metalloproteinase2 cleaves CXCL12α (stromal cell derived factor 1α) and causes neurodegeneration

Autor: Bryan J. Pfister, Debanjan Haldar, P. M. Abdul-Muneer, Rachel K. Patel, Christopher M. Overall, Vijayalakshmi Santhakumar, Mathew Long, Adriano Andrea Conte

Publikováno v: Brain, behavior, and immunity. 59

Traumatic brain injury (TBI), even at mild levels, can activate matrix metalloproteinases (MMPs) and the induction of neuroinflammation that can result in blood brain barrier breakdown and neurodegeneration. MMP2 has a significant role in neuroinflam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3a0f6653ed81240eed2645fc6e4db1
https://pubmed.ncbi.nlm.nih.gov/27614125

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High Ca(2+) Influx During Traumatic Brain Injury Leads to Caspase-1-Dependent Neuroinflammation and Cell Death

Autor: Bryan J. Pfister, Vijayalakshmi Santhakumar, Adriano Andrea Conte, Mathew Long, P. M. Abdul-Muneer

Publikováno v: Mol Neurobiol
Molecular neurobiology, vol 54, iss 6

We investigated the hypothesis that high Ca(2+) influx during traumatic brain injury induces the activation of the caspase-1 enzyme, which triggers neuroinflammation and cell apoptosis in a cell culture model of neuronal stretch injury and an in vivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::050f9d8f02de610f5fbd14a7ff562fa1
https://europepmc.org/articles/PMC9527089/

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