Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Mathew J. Koretsky"'
Autor:
Anant Dadu, Vipul K. Satone, Rachneet Kaur, Mathew J. Koretsky, Hirotaka Iwaki, Yue A. Qi, Daniel M. Ramos, Brian Avants, Jacob Hesterman, Roger Gunn, Mark R. Cookson, Michael E. Ward, Andrew B. Singleton, Roy H. Campbell, Mike A. Nalls, Faraz Faghri
Publikováno v:
Patterns, Vol 4, Iss 6, Pp 100741- (2023)
Summary: High-dimensional data analysis starts with projecting the data to low dimensions to visualize and understand the underlying data structure. Several methods have been developed for dimensionality reduction, but they are limited to cross-secti
Externí odkaz:
https://doaj.org/article/ad52d417db9a4335834e045b65448695
Publikováno v:
Journal of Clinical Monitoring and Computing. 37:501-508
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d4e0d65847e1724e2aabaa6447da06a
https://doi.org/10.1007/s10877-022-00908-z
https://doi.org/10.1007/s10877-022-00908-z
Autor:
Chelsea X. Alvarado, Mary B. Makarious, Dan Vitale, Mathew J. Koretsky, Sara Bandres-Ciga, Hirotaka Iwaki, Kristin Levine, Andrew Singleton, Faraz Faghri, Mike A. Nalls, Hampton L. Leonard
Publikováno v:
medRxiv
Treatments for neurodegenerative disorders remain rare, although recent FDA approvals, such as Lecanemab and Aducanumab for Alzheimer’s Disease, highlight the importance of a mechanistic approach in creating disease modifying therapies. As a large
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07acdccbc7c76e9fb254a54189bcc0cf
https://europepmc.org/articles/PMC10120805/
https://europepmc.org/articles/PMC10120805/
Polygenic Parkinson’s disease genetic risk score as risk modifier of parkinsonism in Gaucher disease
Autor:
Cornelis Blauwendraat, Nahid Tayebi, Elizabeth Geena Woo, Grisel Lopez, Luca Fierro, Marco Toffoli, Naomi Limbachiya, Derralynn Hughes, Vanessa Pitz, Dhairya Patel, Dan Vitale, Mathew J. Koretsky, Dena Hernandez, Raquel Real, Roy N. Alcalay, Mike A. Nalls, Huw R. Morris, Anthony H.V. Schapira, Manisha Balwani, Ellen Sidransky
BackgroundBi-allelic pathogenic variants inGBA1are the cause of Gaucher disease (GD1), a lysosomal storage disorder resulting from deficient glucocerebrosidase. HeterozygousGBA1variants are also a common genetic risk factor for Parkinson’s disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284df5aac4e715cbeb128bb7b859b47b
https://doi.org/10.1101/2022.12.19.22280175
https://doi.org/10.1101/2022.12.19.22280175
Autor:
Mathew J Koretsky, Chelsea Alvarado, Mary B Makarious, Dan Vitale, Kristin Levine, Sara Bandres-Ciga, Anant Dadu, Sonja W Scholz, Lana Sargent, Faraz Faghri, Hirotaka Iwaki, Cornelis Blauwendraat, Andrew Singleton, Mike Nalls, Hampton Leonard
Publikováno v:
Brain Advance online publication, n/a (2023). doi:10.1093/brain/awad161
Overlapping symptoms and copathologies are common in closely related neurodegenerative diseases (NDDs). Investigating genetic risk variants across these NDDs can give further insight into disease manifestations. In this study we have leveraged genome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd66ff5a7321395dc339decf8c58597a
https://doi.org/10.1101/2022.12.01.22282945
https://doi.org/10.1101/2022.12.01.22282945
Autor:
Anant Dadu, Vipul K. Satone, Rachneet Kaur, Mathew J. Koretsky, Hirotaka Iwaki, Yue A. Qi, Daniel M. Ramos, Brian Avants, Jacob Hesterman, Roger Gunn, Mark R. Cookson, Michael E. Ward, Andrew B Singleton, Roy H Campbell, Mike A Nalls, Faraz Faghri
Publikováno v:
SSRN Electronic Journal.
Longitudinal multi-dimensional biological datasets are ubiquitous and highly abundant. These datasets are essential to understanding disease progression, identifying subtypes, and drug discovery. Discovering meaningful patterns or disease pathophysio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bbb01592ed132a4175e2bbcd070d13d
https://doi.org/10.2139/ssrn.4292603
https://doi.org/10.2139/ssrn.4292603