Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Mathew D. F. Chiam"'
Autor:
Ming S. Soh, Richard D. Bagnall, Mark F. Bennett, Lauren E. Bleakley, Erlina S. Mohamed Syazwan, A. Marie Phillips, Mathew D. F. Chiam, Chaseley E. McKenzie, Michael Hildebrand, Douglas Crompton, Melanie Bahlo, Christopher Semsarian, Ingrid E. Scheffer, Samuel F. Berkovic, Christopher A. Reid
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 7, Pp 1422-1432 (2021)
Abstract Objective To compare the frequency and impact on the channel function of KCNH2 variants in SUDEP patients with epilepsy controls comprising patients older than 50 years, a group with low SUDEP risk, and establish loss‐of‐function KCNH2 v
Externí odkaz:
https://doaj.org/article/a3cc4ade1c004ddf9b7c1aa827732045
Autor:
Doris Tomas, Victoria M. McLeod, Mathew D. F. Chiam, Nayomi Wanniarachchillage, Wah C. Boon, Bradley J. Turner
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder caused by loss of motor neurons. ALS incidence is skewed towards males with typically earlier age of onset and limb site of onset. The androgen receptor (AR) is
Externí odkaz:
https://doaj.org/article/d568045e10774a8ab9a42419d98dbd32
Autor:
Victoria M. McLeod, Mathew D. F. Chiam, Nirma D. Perera, Chew L. Lau, Wah Chin Boon, Bradley J. Turner
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Sex steroid hormones have been implicated as disease modifiers in the neurodegenerative disorder amyotrophic lateral sclerosis (ALS). Androgens, signalling via the androgen receptor (AR), predominate in males, and have widespread actions in the perip
Externí odkaz:
https://doaj.org/article/92fd79cd0a5a4fa5aab2084315b116af
Autor:
Christopher A. Reid, Christopher Semsarian, Samuel F. Berkovic, A. Marie Phillips, Richard D. Bagnall, Lauren E Bleakley, Erlina S Mohamed Syazwan, Mathew D. F. Chiam, Chaseley E McKenzie, Melanie Bahlo, Mark F. Bennett, Douglas E. Crompton, Michael S. Hildebrand, Ingrid E. Scheffer, Ming S Soh
Publikováno v:
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology, Vol 8, Iss 7, Pp 1422-1432 (2021)
Annals of Clinical and Translational Neurology, Vol 8, Iss 7, Pp 1422-1432 (2021)
Objective To compare the frequency and impact on the channel function of KCNH2 variants in SUDEP patients with epilepsy controls comprising patients older than 50 years, a group with low SUDEP risk, and establish loss‐of‐function KCNH2 variants a
Autor:
Victoria M, McLeod, Mathew D F, Chiam, Nirma D, Perera, Chew L, Lau, Wah Chin, Boon, Bradley J, Turner
Publikováno v:
Frontiers in endocrinology. 13
Sex steroid hormones have been implicated as disease modifiers in the neurodegenerative disorder amyotrophic lateral sclerosis (ALS). Androgens, signalling
Autor:
Doris Tomas, Victoria M. McLeod, Mathew D. F. Chiam, Nayomi Wanniarachchillage, Wah Chin Boon, Bradley J. Turner
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder caused by loss of motor neurons. ALS incidence is skewed towards males with typically earlier age of onset and limb site of onset. The androgen receptor (AR) is the majo
Publikováno v:
genesis. 58
The Cre-loxP strategy for tissue selective gene deletion has become a widely employed tool in neuroscience research. The validity of these models is largely underpinned by the temporal and spatial selectivity of recombinase expression under the promo
Autor:
Thusitha Rupasinghe, Wah Chin Boon, Victoria M. McLeod, Bradley J. Turner, Mathew D. F. Chiam, Chew L. Lau
Publikováno v:
Endocrinology. 161(9)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease targeting motor neurons which shows sexual dimorphism in its incidence, age of onset, and progression rate. All steroid hormones, including androgens, estrogens, and progestogens, hav
Autor:
Philip M Beart, Chew L. Lau, Mathew D. F. Chiam, Samantha K. Barton, Bradley J. Turner, Hakan Muyderman, Doris Tomas
Publikováno v:
Neurochemical research. 45(6)
Motor neuron degeneration in amyotrophic lateral sclerosis (ALS) caused by mutations in superoxide dismutase 1 (SOD1) is partly non-cell autonomous, involving cellular dysfunction of astrocytes. Whether non-cell autonomous effects occur in other form
Autor:
Doris Tomas, Wayne Cawthorne, Nayomi Wanniarachchillage, James M. Murphy, Brittany Cuic, Nirma D Perera, Mathew D. F. Chiam, Andre L. Samson, Bradley J. Turner, Eric N. Valor, Taide Wang
Publikováno v:
Cell Death Differ
Motor neuron degeneration in amyotrophic lateral sclerosis (ALS) is proposed to occur by necroptosis, an inflammatory form of regulated cell death. Prior studies implicated necroptosis in ALS based on accumulation of necroptotic markers in affected t