Výsledky vyhledávání - "Mathew D Minardi"

Akademický článek

Two orthorhombic polymorphs of hydromorphone

Autor: Jaroslaw Mazurek, Marcel Hoffmann, Ana Fernandez Casares, D. Phillip Cox, Mathew D. Minardi, Josh Sasine

Publikováno v: Acta Crystallographica Section E: Crystallographic Communications, Vol 72, Iss 5, Pp 730-733 (2016)

Conditions to obtain two polymorphic forms by crystallization from solution were determined for the analgesic drug hydromorphone [C17H19NO3; systematic name: (4R,4aR,7aR,12bS)-9-hydroxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-

Externí odkaz: https://doaj.org/article/2773389c7854441384ffd46d1e3c9ff0

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Akademický článek

Buprenorphine

Autor: Jaroslaw Mazurek, Marcel Hoffmann, Anna Fernandez Casares, Phillip D. Cox, Mathew D. Minardi

Publikováno v: Acta Crystallographica Section E, Vol 70, Iss 6, Pp o635-o635 (2014)

In the crystal structure of a semi-synthetic opioid drug buprenorphine, C29H41NO4 {systematic name: (2S)-2-[(5R,6R,7R,14S)-9α-cyclopropylmethyl-3-hydroxy-6-methoxy-4,5-epoxy-6,14-ethanomorphinan-7-yl]-3,3-dimethylbutan-2-ol}, the cyclopropylmethyl g

Externí odkaz: https://doaj.org/article/0efa2cbc20c346aa9937a86430beeb1f

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Two orthorhombic polymorphs of hydromorphone

Autor: Marcel Hoffmann, Ana Fernandez Casares, D. Phillip Cox, Josh Sasine, Jaroslaw Mazurek, Mathew D. Minardi

Publikováno v: Acta Crystallographica Section E: Crystallographic Communications
Acta Crystallographica Section E: Crystallographic Communications, Vol 72, Iss 5, Pp 730-733 (2016)

Conditions to obtain two polymorphic forms by crystallization from solution were determined for the analgestic drug hydromorphone. In both polymorphs, the hydromorphone molecules adopt very similar conformations with some small differences obse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f711189a8c21a446482ab29bc5fea0
http://europepmc.org/articles/PMC4908523

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Antineoplastic Agents. 509. Synthesis of Fluorcombstatin Phosphate and Related 3-Halostilbenes,1

Autor: George R. Pettit, Heidi J Rosenberg, Timothy J Cuthbertson, Michael C Bibby, Sandie W Martin, Mathew D Minardi, Jean-Charles Chapuis, Robin K. Pettit, M. Katherine Jung, Ernest Hamel

Publikováno v: Journal of Natural Products. 68:1450-1458

The present SAR study of combretastatin A-3 (3a) focused on replacement of the 3-hydroxyl group by a series of halogens. That approach with Z-stilbenes resulted in greatly enhanced (>10-100-fold) cancer cell growth inhibition against a panel of human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34fa883247b8ee721b353ae0638f28e2
https://doi.org/10.1021/np058038i

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An efficient synthetic strategy for obtaining 4-methoxy carbon isotope labeled combretastatin A-4 phosphate and other Z-combretastatins

Autor: Mathew D. Minardi, Patricia M Price, George R. Pettit, Fiona Hogan

Publikováno v: Journal of natural products. 73(3)

Human cancer and other clinical trials under development employing combretastatin A-4 phosphate (1b, CA4P) should benefit from the availability of a [(11)C]-labeled derivative for positron emission tomography (PET). In order to obtain a suitable prec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e82f9dd95e9d135d4d75ceedb14420
https://pubmed.ncbi.nlm.nih.gov/20028026

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