Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Mathew A. Sloane"'
Autor:
Robyn L. Ward, Jason W.H. Wong, Michael J. Bourke, Nicholas J. Hawkins, Mathew A. Sloane, John E. Pimanda, Caroline E. Ford, Ashraf Dower, Regina Ryan, Dominik Beck, Andrea C. Nunez, Deborah Packham, Chau-To Kwok, Sameer Srivastava, Peter Zarzour, Benedict Ng, Luke B. Hesson
Supplementary Figure S1. LSTs profiled in this study. Supplementary Figure S2. Mutation validation by Sanger sequencing. Supplementary Figure S3. Analytical strategy for identifying LST driver genes and significantly altered pathways. Supplementary F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf457a7e77c5ad70f774c7d2ceabd98
https://doi.org/10.1158/1541-7786.22511728
https://doi.org/10.1158/1541-7786.22511728
Autor:
Robyn L. Ward, Jason W.H. Wong, Michael J. Bourke, Nicholas J. Hawkins, Mathew A. Sloane, John E. Pimanda, Caroline E. Ford, Ashraf Dower, Regina Ryan, Dominik Beck, Andrea C. Nunez, Deborah Packham, Chau-To Kwok, Sameer Srivastava, Peter Zarzour, Benedict Ng, Luke B. Hesson
Laterally spreading tumors (LST) are colorectal adenomas that develop into extremely large lesions with predominantly slow progression to cancer, depending on lesion subtype. Comparing and contrasting the molecular profiles of LSTs and colorectal can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::221fb4456122357be3947d56b7638be5
https://doi.org/10.1158/1541-7786.c.6540025.v1
https://doi.org/10.1158/1541-7786.c.6540025.v1
Autor:
Robyn L. Ward, Jason W.H. Wong, Michael J. Bourke, Nicholas J. Hawkins, Mathew A. Sloane, John E. Pimanda, Caroline E. Ford, Ashraf Dower, Regina Ryan, Dominik Beck, Andrea C. Nunez, Deborah Packham, Chau-To Kwok, Sameer Srivastava, Peter Zarzour, Benedict Ng, Luke B. Hesson
Somatic mutations identified by WES.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0437a134b5b21ebc70c777ab21da6f3e
https://doi.org/10.1158/1541-7786.22511725.v1
https://doi.org/10.1158/1541-7786.22511725.v1
Autor:
John E. Pimanda, Mathew A. Sloane, Luke B. Hesson, Jason W.H. Wong, Robyn L. Ward, Nicholas J. Hawkins, Dominik Beck, Rachel Williams, Rebecca C. Poulos, Deborah Packham, Kathy Knezevic, Yizhou Huang, Andrea C. Nunez, Julie A.I. Thoms, Qing Liu
Supplementary data tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728e2dc12b07d3b367a72ac1efbe46aa
https://doi.org/10.1158/1078-0432.22469436.v1
https://doi.org/10.1158/1078-0432.22469436.v1
Autor:
John E. Pimanda, Mathew A. Sloane, Luke B. Hesson, Jason W.H. Wong, Robyn L. Ward, Nicholas J. Hawkins, Dominik Beck, Rachel Williams, Rebecca C. Poulos, Deborah Packham, Kathy Knezevic, Yizhou Huang, Andrea C. Nunez, Julie A.I. Thoms, Qing Liu
Purpose: MLH1 is a major tumor suppressor gene involved in the pathogenesis of Lynch syndrome and various sporadic cancers. Despite their potential pathogenic importance, genomic regions capable of regulating MLH1 expression over long distances have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a3f18094497583ba0bbffe0939160b
https://doi.org/10.1158/1078-0432.c.6527256.v1
https://doi.org/10.1158/1078-0432.c.6527256.v1
Autor:
John E. Pimanda, Mathew A. Sloane, Luke B. Hesson, Jason W.H. Wong, Robyn L. Ward, Nicholas J. Hawkins, Dominik Beck, Rachel Williams, Rebecca C. Poulos, Deborah Packham, Kathy Knezevic, Yizhou Huang, Andrea C. Nunez, Julie A.I. Thoms, Qing Liu
Supplemental methods and supplemental figures 1-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165f16ab60276a916c80fd6281b2dc50
https://doi.org/10.1158/1078-0432.22469439
https://doi.org/10.1158/1078-0432.22469439
Autor:
John E. Pimanda, Rebecca C. Poulos, Deborah Packham, Rachel Williams, Qing Liu, Mathew A. Sloane, Luke B. Hesson, Jason W. H. Wong, Dominik Beck, Julie A. I. Thoms, Robyn L. Ward, Andrea Nuñez, Yizhou Huang, Nicholas J. Hawkins, Kathy Knezevic
Publikováno v:
Clinical Cancer Research. 24:4602-4611
Purpose: MLH1 is a major tumor suppressor gene involved in the pathogenesis of Lynch syndrome and various sporadic cancers. Despite their potential pathogenic importance, genomic regions capable of regulating MLH1 expression over long distances have
Autor:
Luke B Hesson, Vibha Patil, Mathew A Sloane, Andrea C Nunez, Jia Liu, John E Pimanda, Robyn L Ward
Publikováno v:
PLoS Genetics, Vol 9, Iss 7, p e1003636 (2013)
Hypomethylating agents reactivate tumor suppressor genes that are epigenetically silenced in cancer. Inevitably these genes are resilenced, leading to drug resistance. Using the MLH1 tumor suppressor gene as a model, we showed that decitabine-induced
Externí odkaz:
https://doaj.org/article/a7c73f1b66484fd68949921b4f7fc45a
Publikováno v:
Clinical Epigenetics ISBN: 9789811389573
In a clinical pathology setting, epigenetic testing is rare and underutilised. In this chapter, we describe a patient with early-onset colorectal cancer caused by a constitutional epimutation. This case study emphasises the importance of epigenetic t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c386b69a1d1486065c2587424d2d9b0
https://doi.org/10.1007/978-981-13-8958-0_11
https://doi.org/10.1007/978-981-13-8958-0_11
Publikováno v:
The Journal of Pathology: Clinical Research
Serrated polyposis is a rare disorder characterised by the presence of multiple serrated polyps in the large intestine, and an increased personal and familial risk of colorectal cancer. Knowledge of the molecular characteristics of colonic lesions wh