Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mathew A. Coban"'
Structural and Functional Characterization of the Most Frequent Pathogenic PRKN Substitution p.R275W
Autor:
Bernardo A. Bustillos, Liam T. Cocker, Mathew A. Coban, Caleb A. Weber, Jenny M. Bredenberg, Paige K. Boneski, Joanna Siuda, Jaroslaw Slawek, Andreas Puschmann, Derek P. Narendra, Neill R. Graff-Radford, Zbigniew K. Wszolek, Dennis W. Dickson, Owen A. Ross, Thomas R. Caulfield, Wolfdieter Springer, Fabienne C. Fiesel
Publikováno v:
Cells, Vol 13, Iss 18, p 1540 (2024)
Mutations in the PINK1 and PRKN genes are the most frequent genetic cause of early-onset Parkinson disease. The pathogenic p.R275W substitution in PRKN is the most frequent substitution observed in patients, and thus far has been characterized mostly
Externí odkaz:
https://doaj.org/article/5d6ad57649a348b39690f2d65abfc257
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
The study of protein-protein interactions (PPIs) and the engineering of protein-based inhibitors often employ two distinct strategies. One approach leverages the power of combinatorial libraries, displaying large ensembles of mutant proteins, for exa
Externí odkaz:
https://doaj.org/article/be8d1e8857ee478aad14844512aafaed
Autor:
Mathew A. Coban, Juliet Morrison, Sushila Maharjan, David Hyram Hernandez Medina, Wanlu Li, Yu Shrike Zhang, William D. Freeman, Evette S. Radisky, Karine G. Le Roch, Carla M. Weisend, Hideki Ebihara, Thomas R. Caulfield
Publikováno v:
Biomolecules, Vol 11, Iss 6, p 787 (2021)
COVID-19 is a devastating respiratory and inflammatory illness caused by a new coronavirus that is rapidly spreading throughout the human population. Over the past 12 months, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus res
Externí odkaz:
https://doaj.org/article/5259dd92bbc94afa8affdae5de62738b
Autor:
Mathew A. Coban, Patrick R. Blackburn, Murray L. Whitelaw, Mieke M. van Haelst, Paldeep S. Atwal, Thomas R. Caulfield
Publikováno v:
Biomolecules, Vol 10, Iss 9, p 1314 (2020)
Single-minded homologue 1 (SIM1) is a transcription factor with numerous different physiological and developmental functions. SIM1 is a member of the class I basic helix-loop-helix-PER-ARNT-SIM (bHLH–PAS) transcription factor family, that includes
Externí odkaz:
https://doaj.org/article/fd9cee8ddfeb498d9b1ad6472beae06f
Publikováno v:
Current Drug Discovery Technologies. 18:365-378
Diseases are often caused by mutant proteins. Many drugs have limited effectiveness and/or toxic side effects because of a failure to selectively target the disease-causing mutant variant, rather than the functional wild type protein. Otherwise, the
Autor:
Oleksandr V. Savytskyi, Tiffany N.H. Sirmans, Mathew A. Coban, Caleb A. Weber, Melissa E. Murray, Thomas R. Caulfield
Publikováno v:
Biophysical Journal. 122:471a
Autor:
Erin Miller, Mathew A. Coban, S. John Weroha, Derek C. Radisky, Christine Mehner, Alexandra Hockla, Evette S. Radisky
Publikováno v:
Oncogene
A major clinical challenge of ovarian cancer is the development of malignant ascites accompanied by widespread peritoneal metastasis. In ovarian clear cell carcinoma (OCCC), a challenging subtype of ovarian cancer, this problem is compounded by near-
Autor:
Paldeep S. Atwal, Mathew A. Coban, Murray L. Whitelaw, Patrick R. Blackburn, Thomas R. Caulfield, Mieke M. van Haelst
Publikováno v:
Biomolecules, Vol 10, Iss 1314, p 1314 (2020)
Biomolecules, 10(9):1314, 1-17. Multidisciplinary Digital Publishing Institute (MDPI)
Biomolecules
Volume 10
Issue 9
Coban, M A, Blackburn, P R, Whitelaw, M L, van Haelst, M M, Atwal, P S & Caulfield, T R 2020, ' Structural models for the dynamic effects of loss-of-function variants in the human sim1 protein transcriptional activation domain ', Biomolecules, vol. 10, no. 9, 1314, pp. 1-17 . https://doi.org/10.3390/biom10091314
Biomolecules, 10(9):1314, 1-17. Multidisciplinary Digital Publishing Institute (MDPI)
Biomolecules
Volume 10
Issue 9
Coban, M A, Blackburn, P R, Whitelaw, M L, van Haelst, M M, Atwal, P S & Caulfield, T R 2020, ' Structural models for the dynamic effects of loss-of-function variants in the human sim1 protein transcriptional activation domain ', Biomolecules, vol. 10, no. 9, 1314, pp. 1-17 . https://doi.org/10.3390/biom10091314
Single-minded homologue 1 (SIM1) is a transcription factor with numerous different physiological and developmental functions. SIM1 is a member of the class I basic helix-loop-helix-PER-ARNT-SIM (bHLH&ndash
PAS) transcription factor family, that
PAS) transcription factor family, that
Autor:
Yu Shrike Zhang, David Hyram Hernandez Medina, Thomas R. Caulfield, Wanlu Li, Karine G. Le Roch, Sushila Maharjan, Juliet Morrison, Evette S. Radisky, Mathew A. Coban, Hideki Ebihara, Carla Weisend, William D. Freeman
Publikováno v:
Biomolecules
Volume 11
Issue 6
Biomolecules, Vol 11, Iss 787, p 787 (2021)
Biomolecules, vol 11, iss 6
Volume 11
Issue 6
Biomolecules, Vol 11, Iss 787, p 787 (2021)
Biomolecules, vol 11, iss 6
COVID-19 is a devastating respiratory and inflammatory illness caused by a new coronavirus that is rapidly spreading throughout the human population. Over the past 12 months, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus res
Autor:
Lori A. Hazlehurst, Karen E. Hayes, Yushi Qiu, Han W. Tun, Amy L. Lane, Takehiko Yoshimitsu, Joon Seok Oh, Thomas R. Caulfield, Mathew A. Coban, John A. Copland
Publikováno v:
Biomolecules
Volume 10
Issue 10
Biomolecules, Vol 10, Iss 1407, p 1407 (2020)
Volume 10
Issue 10
Biomolecules, Vol 10, Iss 1407, p 1407 (2020)
Chloroethylagelastatin A (CEAA) is an analogue of agelastatin A (AA), a natural alkaloid derived from a marine sponge. It is under development for therapeutic use against brain tumors as it has excellent central nervous system (CNS) penetration and p