Evaluation of Anti-Trypanosoma cruzi Activity of Chemical Constituents from Baccharis sphenophylla Isolated Using High-Performance Countercurrent Chromatography

Autor: Matheus L. Silva, Felipe S. Sales, Erica V. C. Levatti, Guilherme M. Antar, Andre G. Tempone, João Henrique G. Lago, Gerold Jerz

Publikováno v: Molecules, Vol 29, Iss 1, p 212 (2023)

Endemic in 21 countries, Chagas disease, also known as American Trypanosomiasis, is a neglected tropical disease (NTD) caused by the protozoan parasite Trypanosoma cruzi. The available drugs for the treatment of this disease, benznidazole and nifurti

Externí odkaz: https://doaj.org/article/db14e826885d4677b2e6cfeaa51f20b6

Leishmanicidal Activity and Ultrastructural Changes of Maslinic Acid Isolated from Hyptidendron canum

Autor: Jéssica Adriana Jesus, Márcia Dalastra Laurenti, Matheus L. Silva, João Henrique G. Lago, Luiz Felipe Domingues Passero

Publikováno v: Evidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP

Made available in DSpace on 2022-04-29T08:29:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 The therapeutic arsenal for the treatment of leishmaniasis is limited and has serious obstacles, such as variable activity, high toxicity, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da14f66f02ad0afc018100f58a139936
https://doi.org/10.1155/2021/9970983

Selective cytotoxicity of ent ‐kaurene diterpenoids isolated from Baccharis lateralis and Baccharis retusa (Asteraceae)

Autor: Matheus L. Silva, Cyntia S. Oliveira, Wagner J. O. dos Santos, Vani X. Oliveira, Guilherme M. Antar, João H. G. Lago, Giselle Cerchiaro

Publikováno v: Archiv der Pharmazie. 355:2200083

This study presents the cytotoxic activity evaluation of the natural diterpenes ent-kaurenoic acid (1) and its 15β-hydroxy (2), 15β-senecioyloxy (3), and 15β-tiglinoyloxy (4) derivatives, isolated from Brazilian native plants, Baccharis retusa and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089669ff663ddb0616f8c45b4a576c9b
https://doi.org/10.1002/ardp.202200083