Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Matheswaran Kandasamy"'
Autor:
Matheswaran Kandasamy, Uzi Gileadi, Pramila Rijal, Tiong Kit Tan, Lian N Lee, Jili Chen, Gennaro Prota, Paul Klenerman, Alain Townsend, Vincenzo Cerundolo
Publikováno v:
eLife, Vol 12 (2023)
Virus-based tumour vaccines offer many advantages compared to other antigen-delivering systems. They generate concerted innate and adaptive immune response, and robust CD8+ T cell responses. We engineered a non-replicating pseudotyped influenza virus
Externí odkaz:
https://doaj.org/article/19381c4da57642bb86445baca9176ae3
Autor:
Olivia K Burn, Kathryn Farrand, Tara Pritchard, Sarah Draper, Ching‐wen Tang, Anna H Mooney, Alfonso J Schmidt, Sung H Yang, Geoffrey M Williams, Margaret A Brimble, Matheswaran Kandasamy, Andrew J Marshall, Kate Clarke, Gavin F Painter, Ian F Hermans, Robert Weinkove
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 7, Pp n/a-n/a (2022)
Abstract Objectives Metastasis is the principal cause of breast cancer mortality. Vaccines targeting breast cancer antigens have yet to demonstrate clinical efficacy, and there remains an unmet need for safe and effective treatment to reduce the risk
Externí odkaz:
https://doaj.org/article/3c9b77a20a6e4b3da7b8452985eb9f84
Autor:
Ramar Perumal Samy, Stephen P. Mackessy, Alagarmalai Jeyasankar, Mano Ranjana Ponraj, Octavio Luiz Franco, Matthew A. Cooper, Matheswaran Kandasamy, Tapan Kumar Mohanta, Jebasingh Bhagavathsingh, Sakthivel Vaiyapuri
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4359 (2023)
Infections caused by multi-drug-resistant (MDR) bacteria are a global threat to human health. As venoms are the source of biochemically diverse bioactive proteins and peptides, we investigated the antimicrobial activity and murine skin infection mode
Externí odkaz:
https://doaj.org/article/e336fa1efb004257ac5e1b3f9724d139
Autor:
Vincenzo Cerundolo, Eugene Shenderov, Matheswaran Kandasamy, Uzi Gileadi, Jili Chen, Dawn Shepherd, James Gibbs, Gennaro Prota, Jonathan D Silk, Jonathan W Yewdell
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Background NY-ESO-1 is a tumor-specific, highly immunogenic, human germ cell antigen of the MAGE-1 family that is a promising vaccine and cell therapy candidate in clinical trial development. The mouse genome does not encode an NY-ESO-1 homolog there
Externí odkaz:
https://doaj.org/article/a24b481c56034796b4410d660f7ec87d
Autor:
Julianna Han, Jasmine T. Perez, Cindy Chen, Yan Li, Asiel Benitez, Matheswaran Kandasamy, Yoontae Lee, Jorge Andrade, Benjamin tenOever, Balaji Manicassamy
Publikováno v:
Cell Reports, Vol 23, Iss 2, Pp 596-607 (2018)
Summary: The emergence of influenza A viruses (IAVs) from zoonotic reservoirs poses a great threat to human health. As seasonal vaccines are ineffective against zoonotic strains, and newly transmitted viruses can quickly acquire drug resistance, ther
Externí odkaz:
https://doaj.org/article/484a6b7b2a1e4ea8ada4e227090cb69a
Publikováno v:
Microbiome, Vol 6, Iss 1, Pp 1-17 (2018)
Abstract Background Microbiota integrity is essential for a growing number of physiological processes. Consequently, disruption of microbiota homeostasis correlates with a variety of pathological states. Importantly, commensal microbiota provide a sh
Externí odkaz:
https://doaj.org/article/cc6cee20053146cba52329a7b662c8d0
Autor:
Smanla Tundup, Matheswaran Kandasamy, Jasmine T Perez, Nacho Mena, John Steel, Tamas Nagy, Randy A Albrecht, Balaji Manicassamy
Publikováno v:
PLoS Pathogens, Vol 13, Iss 3, p e1006270 (2017)
The cellular and molecular mechanisms underpinning the unusually high virulence of highly pathogenic avian influenza H5N1 viruses in mammalian species remains unknown. Here, we investigated if the cell tropism of H5N1 virus is a determinant of enhanc
Externí odkaz:
https://doaj.org/article/02dce94abd574257b95f79b205a92cac
Autor:
Matheswaran Kandasamy, Amol Suryawanshi, Smanla Tundup, Jasmine T Perez, Mirco Schmolke, Santhakumar Manicassamy, Balaji Manicassamy
Publikováno v:
PLoS Pathogens, Vol 12, Iss 7, p e1005754 (2016)
Retinoic acid inducible gene-I (RIG-I) is an innate RNA sensor that recognizes the influenza A virus (IAV) RNA genome and activates antiviral host responses. Here, we demonstrate that RIG-I signaling plays a crucial role in restricting IAV tropism an
Externí odkaz:
https://doaj.org/article/847215f233cd4663a1b973a9c87fa811
Autor:
Shirong Cai, Matheswaran Kandasamy, Juwita N. Rahmat, Sin Mun Tham, Boon Huat Bay, Yuan Kun Lee, Ratha Mahendran
Publikováno v:
Journal of Immunology Research, Vol 2016 (2016)
This study evaluates the ability of Lactobacillus rhamnosus GG (LGG) to activate DC and neutrophils and modulate T cell activation and the impact of bacterial dose on these responses. Murine bone marrow derived DC or neutrophils were stimulated with
Externí odkaz:
https://doaj.org/article/f03d3d83483e4455ab29e9a5068ec240
Autor:
Ramar Perumal Samy, Matheswaran Kandasamy, Ponnampalam Gopalakrishnakone, Bradley G Stiles, Edward G Rowan, David Becker, Muthu K Shanmugam, Gautam Sethi, Vincent T K Chow
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e80199 (2014)
Basic phospholipase A2 was identified from the venom of the eastern diamondback rattlesnake. The Crotalus adamanteus toxin-II (CaTx-II) induced bactericidal effects (7.8 µg/ml) on Staphylococcus aureus, while on Burkholderia pseudomallei (KHW), and
Externí odkaz:
https://doaj.org/article/5ade61f0dd7f4795b1c20628fab59e9e