Rationally modified SNX-class Hsp90 inhibitors disrupt extracellular fibronectin assembly without intracellular Hsp90 activity.

Autor: Mathenjwa GS; Department of Chemistry, University of Cape Town Rondebosch Cape Town 7701 South Africa clinton.veale@uct.ac.za.; School of Chemistry and Physics, University of KwaZulu-Natal Private Bag X01 Scottsville 3209 South Africa., Chakraborty A; The Biomedical Biotechnology Research Unit (BioBRU), Department of Biochemistry and Microbiology, Rhodes University Makhanda 6139 South Africa a.edkins@ru.ac.za., Chakraborty A; The Biomedical Biotechnology Research Unit (BioBRU), Department of Biochemistry and Microbiology, Rhodes University Makhanda 6139 South Africa a.edkins@ru.ac.za., Muller R; School of Chemistry and Physics, University of KwaZulu-Natal Private Bag X01 Scottsville 3209 South Africa., Akerman MP; School of Chemistry and Physics, University of KwaZulu-Natal Private Bag X01 Scottsville 3209 South Africa., Bode ML; Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand Private Bag 3, PO WITS 2050 Johannesburg South Africa., Edkins AL; The Biomedical Biotechnology Research Unit (BioBRU), Department of Biochemistry and Microbiology, Rhodes University Makhanda 6139 South Africa a.edkins@ru.ac.za., Veale CGL; Department of Chemistry, University of Cape Town Rondebosch Cape Town 7701 South Africa clinton.veale@uct.ac.za.

Publikováno v: RSC medicinal chemistry [RSC Med Chem] 2024 Sep 02. Date of Electronic Publication: 2024 Sep 02.