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pro vyhledávání: '"Mathematical genetics"'
Akademický článek
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Autor:
Ananthamohan Kalyani, Parshuram J. Sonawane, Nitish R. Mahapatra, Lakshmi Subramanian, Ajit S. Mullasari, Georg Ehret, Abrar A. Khan
Publikováno v:
Journal of Molecular Biology, Vol. 427, No 16 (2015) pp. 2629-2646
Renalase, a recently identified oxidoreductase, is emerging as a novel regulator of cardiovascular and metabolic disease states. The mechanism of regulation of renalase gene, especially at the post-transcriptional level, is completely unknown. We set
Autor:
O’Donald, Peter
Publikováno v:
Heredity. May2000, Vol. 84 Issue 5, p620-621. 2p.
Autor:
Krohn, J, Krohn, Jonathan
Anxiety and depression are highly prevalent diseases with common heritable elements, but the particular genetic mechanisms and biological pathways underlying them are poorly understood. Part of the challenge in understanding the genetic basis of thes
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https://ora.ox.ac.uk/objects/uuid:1e8e40bd-9a98-405f-9463-e9423f0a60ca
Autor:
Rivas Cruz, Manuel A.
Genome-wide association studies have greatly improved our understanding of the contribution of common variants to the genetic architecture of complex traits. However, two major limitations have been highlighted. First, common variant associations typ
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.664835
Autor:
Randall, J, Randall, Joshua Charles
Recent advances in genotyping technology coupled with an improved understanding of the architecture of linkage disequilibrium across the human genome have resulted in genome-wide association studies (GWAS) becoming a useful and widely applied tool fo
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Autor:
Venn, O
In eukaryotes, recombination plays a critical role in both the production of viable gametes and as a population genetic process. Here, we are interested in studying recombination as it provides insight into a process that has shaped variation. To thi
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Autor:
Hechter, E
Genome-wide association studies (GWAS) exploit the correlation in ge- netic diversity along chromosomes in order to detect effects on disease risk without having to type causal loci directly. The inevitable downside of this approach is that, when the
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https://ora.ox.ac.uk/objects/uuid:d883f20e-7dad-4216-8851-b006993832fd
Autor:
Hosseini, M
Variation at regulatory elements, identified through hypersensitivity to digestion by Deoxyribonuclease I (DNase I), is believed to contribute to variation in complex traits, but the extent and consequences of this variation are poorly characterized.
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Autor:
Wilson, D
Neisseria meningitidis is the bacterium responsible for meningococcal meningitis and septicaemia in humans. Meningococcal disease is primarily a disease of young children, characterized by rapid deterioration from first symptoms to death, with an 11%
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