Zobrazeno 1 - 10
of 532
pro vyhledávání: '"Mathematical biosciences"'
Autor:
Nadine Benhamouda, Anissa Besbes, Rebecca Bauer, Nesrine Mabrouk, Gauthier Gadouas, Corinne Desaint, Lucie Chevrier, Maeva Lefebvre, Anne Radenne, Marie Roelens, Béatrice Parfait, Daniela Weiskopf, Alessandro Sette, Nadège Gruel, Marie Courbebaisse, Victor Appay, Stephane Paul, Guy Gorochov, Jacques Ropers, Said Lebbah, Jean-Daniel Lelievre, Ludger Johannes, Jonathan Ulmer, David Lebeaux, Gerard Friedlander, Xavier De Lamballerie, Patrice Ravel, Marie Paule Kieny, Fréderic Batteux, Christine Durier, Odile Launay, Eric Tartour
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110441- (2024)
Summary: Coordinating immune responses – humoral and cellular – is vital for protection against severe Covid-19. Our study evaluates a multicytokine CD4+T cell signature’s predictive for post-vaccinal serological and CD8+T cell responses. A cyt
Externí odkaz:
https://doaj.org/article/bae9b74a735344409d5106899f8ed864
Autor:
Luciano M. Matzkin, Jeremy M. Bono, Helen K. Pigage, Carson W. Allan, Fernando Diaz, John R. McCoy, Clinton C. Green, Jeffrey B. Callan, Stephen P. Delahunt, II
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110442- (2024)
Summary: Although RNA is found in the seminal fluid of diverse organisms, it is unknown whether it is functional within females. We developed a proteomic method (VESPA, Variant Enabled SILAC Proteomic Analysis) to test the hypothesis that Drosophila
Externí odkaz:
https://doaj.org/article/0f8b2f07785c4a4c88fdd3adc8d298a5
Autor:
Paras Jain, Ramanarayanan Kizhuttil, Madhav B. Nair, Sugandha Bhatia, Erik W. Thompson, Jason T. George, Mohit Kumar Jolly
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110310- (2024)
Summary: Cancer cell populations comprise phenotypes distributed among the epithelial-mesenchymal (E-M) spectrum. However, it remains unclear which population-level processes give rise to the observed experimental distribution and dynamical changes i
Externí odkaz:
https://doaj.org/article/5f1ae3eab23e4434bf004a430eb4ab45
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110262- (2024)
Summary: Positive autoregulation (PAR), one type of network motifs, provides a high phenotypic heterogeneity for cells to better adapt to their microenvironments. Typical mechanosensitive proteins can also form PAR, e.g., integrin mediated PAR, but t
Externí odkaz:
https://doaj.org/article/a9640baa201646a293f0fb4b89aee312
Autor:
Sarthak Sahoo, Soundharya Ramu, Madhumathy G. Nair, Maalavika Pillai, Beatriz P. San Juan, Heloisa Zaccaron Milioli, Susmita Mandal, Chandrakala M. Naidu, Apoorva D. Mavatkar, Harini Subramaniam, Arpita G. Neogi, Christine L. Chaffer, Jyothi S. Prabhu, Jason A. Somarelli, Mohit Kumar Jolly
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110116- (2024)
Summary: Intra-tumoral phenotypic heterogeneity promotes tumor relapse and therapeutic resistance and remains an unsolved clinical challenge. Decoding the interconnections among different biological axes of plasticity is crucial to understand the mol
Externí odkaz:
https://doaj.org/article/184f963418524796bef6f9437338f851
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109833- (2024)
Summary: Insulin plays a crucial role in regulating the metabolism of blood glucose, amino acids (aa), and lipids in humans. However, the mechanisms by which insulin selectively regulates these metabolites are not fully understood. To address this qu
Externí odkaz:
https://doaj.org/article/365d925c20a64d08ac312c140eff6e90
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110134- (2024)
Summary: Effective immune-cell responses depend on collective decision-making mediated by diffusible intercellular signaling proteins called cytokines. Here, we designed a three-dimensional spatiotemporal modeling framework and a precise finite-eleme
Externí odkaz:
https://doaj.org/article/7747eb6c10914b7daea23b8e59e28d9d
Autor:
Oscar O. Ortega, Mustafa Ozen, Blake A. Wilson, James C. Pino, Michael W. Irvin, Geena V. Ildefonso, Shawn P. Garbett, Carlos F. Lopez
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109989- (2024)
Summary: Mathematical models of biomolecular networks are commonly used to study cellular processes; however, their usefulness to explain and predict dynamic behaviors is often questioned due to the unclear relationship between parameter uncertainty
Externí odkaz:
https://doaj.org/article/45524559fe434959b7d7a8039ede7510
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109708- (2024)
Summary: During aging, skin homeostasis is essential for maintaining appearance, as well as biological defense of the human body. In this study, we identified thrombospondin-1 (THBS1) and fibromodulin (FMOD) as positive and negative regulators, respe
Externí odkaz:
https://doaj.org/article/7df7f493cf824435be08125f652181d1
Autor:
José Antonio Romero-Rosales, David G. Aragones, José Escribano-Serrano, Marisa González Borrachero, Alfredo Michán Doña, Francisco J. Macías López, María Angeles Santos Mata, Inmaculada Naranjo Jiménez, María Jesús Casamitjana Zamora, Hélia Serrano, Juan Belmonte-Beitia, María Rosa Durán, Gabriel F. Calvo
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109369- (2024)
Summary: Metabolic biomarkers, particularly glycated hemoglobin and fasting plasma glucose, are pivotal in the diagnosis and control of diabetes mellitus. Despite their importance, they exhibit limitations in assessing short-term glucose variations.
Externí odkaz:
https://doaj.org/article/eaff09f7adae4cd284225b8ceca1ca4d