Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Mathäus Niemietz"'
Autor:
Theodoros Karagiannis, Mathäus Niemietz, Carlo Unverzagt, Mónica Martínez-Orts, Marie Lott, Nahid Razi, James C. Paulson, Dimitri Ott, Steffen Eller, Ángeles Canales, Markus Weishaupt, Michael Weiss
Publikováno v:
Chembiochem
In human serum immunoglobulin G (IgG), a rare modification of biantennary complex N‐glycans lead to a β1,4‐galactosylated bisecting GlcNAc branch. We found that the bisecting GlcNAc on a biantennary core‐fucosylated N‐glycan was enzymaticall
Autor:
Cathrin Wirkner, Janika Walcher, Matthias Pischl, Joanna Hoffman, Dimitri Ott, Manuel Mönnich, Markus Weishaupt, Theodoros Karagiannis, Carlo Unverzagt, Rachel G. Lichtenstein, Lukas Perkams, Mathäus Niemietz, Lukas Berger, Thomas Luber, Steffen Eller
Publikováno v:
Angewandte Chemie. 128:10643-10648
Die Gegenwart von N-Glycanen mit einer bisecting GlcNAc-Modifikation auf Glycoproteinen hat viele Auswirkungen in der Entwicklungs- und Immunbiologie. Allerdings ist es schwierig diese N-Glycane aus der Natur oder durch Synthese zu erhalten. Fur bise
Autor:
Dimitri Ott, Manuel Mönnich, Joanna Hoffman, Matthias Pischl, Markus Weishaupt, Lukas Berger, Theodoros Karagiannis, Mathäus Niemietz, Janika Walcher, Carlo Unverzagt, Lukas Perkams, Thomas Luber, Steffen Eller
Publikováno v:
Angewandte Chemie (International ed. in English). 57(44)
The occurrence of α1,6-linked core fucose on the N-glycans of mammalian glycoproteins is involved in tumor progression and reduces the bioactivity of antibodies in antibody-dependent cell-mediated cytotoxicity (ADCC). Since core-fucosylated N-glycan
Autor:
Markus Weishaupt, Manuel Mönnich, Joanna Hoffman, Janika Walcher, Lukas Perkams, Thomas Luber, Matthias Pischl, Dimitri Ott, Carlo Unverzagt, Lukas Berger, Theodoros Karagiannis, Mathäus Niemietz, Cathrin Wirkner, Steffen Eller, Rachel G. Lichtenstein
Publikováno v:
Angewandte Chemie (International ed. in English). 55(35)
The occurrence of N-glycans with a bisecting GlcNAc modification on glycoproteins has many implications in developmental and immune biology. However, these particular N-glycans are difficult to obtain either from nature or through synthesis. We have
Autor:
Manuel Mönnich, Joachim Seifert, Carlo Unverzagt, Janna Guder, Ingo Prahl, Mathäus Niemietz, Dimitri Ott, Joanna Hoffman
Publikováno v:
European Journal of Organic Chemistry. 2012:5054-5068
A modular synthesis of complex-type N-glycans containing the core fucosyl motif was optimized. The core trisaccharide building block was protected by a methoxyphenyl group for convenient core fucosylation. The trisaccharide was obtained on a large sc
Publikováno v:
Tetrahedron Letters. 51:2648-2651
A straightforward chemical synthesis was developed for multiantennary N-glycans of the complex-type containing a bisecting GlcNAc moiety. It was found that a bisecting GlcNAc can be introduced as the final residue despite considerable steric hindranc
Autor:
Claudia Raps, Gislinde Gundel, Mathäus Niemietz, Ralf Schuberth, Matthias Pischl, Joachim Seifert, Steffen Eller, Harald Weiss, Carlo Unverzagt
Publikováno v:
Chemistry - A European Journal. 15:12292-12302
A modular set of oligosaccharide building blocks was developed for the synthesis of multiantennary N-glycans of the complex type, which are commonly found on glycoproteins. The donor building blocks were laid out for the elongation of a core trisacch