Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Mateusz Jakub Lezyk"'
Autor:
Maria Dalgaard Mikkelsen, Hang Thi Thuy Cao, Thomas Roret, Nanna Rhein-Knudsen, Jesper Holck, Van Thi Thanh Tran, Thuan Thi Nguyen, Vy Ha Nguyen Tran, Mateusz Jakub Lezyk, Jan Muschiol, Thinh Duc Pham, Mirjam Czjzek, Anne S. Meyer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Fucoidans are sulfated, fucose-rich marine polysaccharides primarily found in cell walls of brown seaweeds (macroalgae). Fucoidans are known to possess beneficial bioactivities depending on their structure and sulfation degree. Here, we repo
Externí odkaz:
https://doaj.org/article/cc38177e7dd745e28e3da788539a2bda
Autor:
Mirjam Czjzek, Anne S. Meyer, Van Thi Thanh Tran, Thuan Thi Nguyen, Thomas Roret, Nanna Rhein-Knudsen, Vy Ha Nguyen Tran, Jesper Holck, Thinh Duc Pham, Jan Muschiol, Hang Thi Thuy Cao, Maria Dalgaard Mikkelsen, Mateusz Jakub Lezyk
Publikováno v:
Scientific Reports
Scientific Reports, Nature Publishing Group, 2021, 11 (1), ⟨10.1038/s41598-021-98588-3⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Mikkelsen, M D, Cao, H T T, Roret, T, Rhein-Knudsen, N, Holck, J, Tran, V T T, Nguyen, T T, Tran, V H N, Lezyk, M J, Muschiol, J, Pham, T D, Czjzek, M & Meyer, A S 2021, ' A novel thermostable prokaryotic fucoidan active sulfatase PsFucS1 with an unusual quaternary hexameric structure ', Scientific Reports, vol. 11, 19523 . https://doi.org/10.1038/s41598-021-98588-3
Scientific Reports, Nature Publishing Group, 2021, 11 (1), ⟨10.1038/s41598-021-98588-3⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Mikkelsen, M D, Cao, H T T, Roret, T, Rhein-Knudsen, N, Holck, J, Tran, V T T, Nguyen, T T, Tran, V H N, Lezyk, M J, Muschiol, J, Pham, T D, Czjzek, M & Meyer, A S 2021, ' A novel thermostable prokaryotic fucoidan active sulfatase PsFucS1 with an unusual quaternary hexameric structure ', Scientific Reports, vol. 11, 19523 . https://doi.org/10.1038/s41598-021-98588-3
Fucoidans are sulfated, fucose-rich marine polysaccharides primarily found in cell walls of brown seaweeds (macroalgae). Fucoidans are known to possess beneficial bioactivities depending on their structure and sulfation degree. Here, we report the fi
Autor:
Ly Minh Bui, Mateusz Jakub Lezyk, Artem S. Silchenko, Bang H Truong, Jesper Holck, Mikhail I. Kusaykin, Maria Dalgaard Mikkelsen, Hang T T Cao, Anne S. Meyer, Thinh Duc Pham, Van Thi Thanh Tran
Publikováno v:
Marine Drugs, Vol 16, Iss 11, p 422 (2018)
Marine Drugs
Cao, H T T, Mikkelsen, M D, Lezyk, M J, Bui, L M, Tran, V T T, Silchenko, A S, Kusaykin, M I, Pham, T D, Truong, B H, Holck, J & Meyer, A S 2018, ' Novel Enzyme Actions for Sulphated Galactofucan Depolymerisation and a New Engineering Strategy for Molecular Stabilisation of Fucoidan Degrading Enzymes ', Marine Drugs, vol. 16, no. 11, 422 . https://doi.org/10.3390/md16110422
Volume 16
Issue 11
Marine Drugs
Cao, H T T, Mikkelsen, M D, Lezyk, M J, Bui, L M, Tran, V T T, Silchenko, A S, Kusaykin, M I, Pham, T D, Truong, B H, Holck, J & Meyer, A S 2018, ' Novel Enzyme Actions for Sulphated Galactofucan Depolymerisation and a New Engineering Strategy for Molecular Stabilisation of Fucoidan Degrading Enzymes ', Marine Drugs, vol. 16, no. 11, 422 . https://doi.org/10.3390/md16110422
Volume 16
Issue 11
Fucoidans from brown macroalgae have beneficial biomedical properties but their use as pharma products requires homogenous oligomeric products. In this study, the action of five recombinant microbial fucoidan degrading enzymes were evaluated on fucoi
Autor:
Anne S. Meyer, Mateusz Jakub Lezyk, Birgitte Zeuner, Mattias Raae Gedde, Jan Muschiol, Jørn Dalgaard Mikkelsen, Carsten Jers, Jesper Holck
Publikováno v:
Zeuner, B, Muschiol, J, Holck, J, Lezyk, M, Gedde, M R, Jers, C, Mikkelsen, J D & Meyer, A S 2018, ' Substrate specificity and transfucosylation activity of GH29 α-l-fucosidases for enzymatic production of human milk oligosaccharides ', New Biotechnology, vol. 41, pp. 34-45 . https://doi.org/10.1016/j.nbt.2017.12.002
Human milk oligosaccharides (HMOs) constitute a unique family of bioactive lactose-based molecules present in human breast milk. HMOs are of major importance for infant health and development but also virtually absent from bovine milk used for infant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6907f967507ccdd76afb617d2b3cdb62
https://orbit.dtu.dk/en/publications/162963af-31aa-4ddd-851b-535e4a104d94
https://orbit.dtu.dk/en/publications/162963af-31aa-4ddd-851b-535e4a104d94
Homology to peptide pattern for annotation of carbohydrate-active enzymes and prediction of function
Publikováno v:
Busk, P K, Pilgaard, B, Lezyk, M J, Meyer, A S & Lange, L 2017, ' Homology to peptide pattern for annotation of carbohydrate-active enzymes and prediction of function ', B M C Bioinformatics, vol. 18, 214 . https://doi.org/10.1186/s12859-017-1625-9
BMC Bioinformatics
BMC Bioinformatics, Vol 18, Iss 1, Pp 1-9 (2017)
BMC Bioinformatics
BMC Bioinformatics, Vol 18, Iss 1, Pp 1-9 (2017)
Background Carbohydrate-active enzymes are found in all organisms and participate in key biological processes. These enzymes are classified in 274 families in the CAZy database but the sequence diversity within each family makes it a major task to id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e22452525d5f92ccb0c222fcdb7f0017
https://orbit.dtu.dk/en/publications/17122a95-abc6-4153-af5c-8f40ad24eefe
https://orbit.dtu.dk/en/publications/17122a95-abc6-4153-af5c-8f40ad24eefe
Autor:
Charlotte Held Gotfredsen, Maria Dalgaard Mikkelsen, Louise Kjaerulff, Jørn Dalgaard Mikkelsen, Carsten Jers, Mateusz Jakub Lezyk
Publikováno v:
Lezyk, M J, Jers, C, Kjaerulff, L, Gotfredsen, C H, Mikkelsen, M D & Mikkelsen, J D 2016, ' Novel α-L-Fucosidases from a Soil Metagenome for Production of Fucosylated Human Milk Oligosaccharides ', P L o S One, vol. 11, no. 1, e0147438 . https://doi.org/10.1371/journal.pone.0147438
Lezyk, M J, Jers, C, Kjærulff, L, Gotfredsen, C H, Mikkelsen, M D & Mikkelsen, J D 2016, ' Novel α-L-fucosidases from a soil metagenome for production of fucosylated human milk oligosaccharides ', P L o S One, vol. 11, no. 1, e0147438 . https://doi.org/10.1371/journal.pone.0147438
PLoS ONE, Vol 11, Iss 1, p e0147438 (2016)
PLoS ONE
Lezyk, M J, Jers, C, Kjærulff, L, Gotfredsen, C H, Mikkelsen, M D & Mikkelsen, J D 2016, ' Novel α-L-fucosidases from a soil metagenome for production of fucosylated human milk oligosaccharides ', P L o S One, vol. 11, no. 1, e0147438 . https://doi.org/10.1371/journal.pone.0147438
PLoS ONE, Vol 11, Iss 1, p e0147438 (2016)
PLoS ONE
This paper describes the discovery of novel α-L-fucosidases and evaluation of their potential to catalyse the transglycosylation reaction leading to production of fucosylated human milk oligosaccharides. Seven novel α-L-fucosidase-encoding genes we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2afd2706e73e6ef5a418320b0413a70
https://orbit.dtu.dk/en/publications/12cde837-45d3-4cb1-bf7f-901125d9a783
https://orbit.dtu.dk/en/publications/12cde837-45d3-4cb1-bf7f-901125d9a783
Publikováno v:
Sitarz, A K, Mikkelsen, J D, Meyer, A S & Lezyk, M J Mar. 20 2014, A Novel Laccase from Ganoderma Lucidum Capable of Enhancing Enzymatic Degradation of Lignocellulolytic Biomass, Patent No. WO2014041030 .
Technical University of Denmark Orbit
Technical University of Denmark Orbit
The invention addresses the need for enzymes that can enhance the yield of fermentable sugar from the hydrolysis of lignocellulose biomass, for example sugar cane bagasse, barley straw and wheat straw, such that the use of this biomass can become eco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::9eabbd18fe68b41effe2d12fcc2031a8
https://orbit.dtu.dk/en/publications/b7639607-5424-43b0-83cf-7b5916bb99d8
https://orbit.dtu.dk/en/publications/b7639607-5424-43b0-83cf-7b5916bb99d8
Autor:
Peter Ruhdal Jensen, Christian Solem, Jun Chen, Søren Helmark, Mateusz Jakub Lezyk, Jakob Vang Rytter
Publikováno v:
Applied microbiology and biotechnology. 98(6)
The ability to modulate gene expression is an important genetic tool in systems biology and biotechnology. Here, we demonstrate that a previously published easy and fast PCR-based method for modulating gene expression in lactic acid bacteria is also