Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Mateusz Daśko"'
Autor:
Karol Biernacki, Olga Ciupak, Mateusz Daśko, Janusz Rachon, Damian Flis, Justyna Budka, Iwona Inkielewicz-Stępniak, Anna Czaja, Janusz Rak, Sebastian Demkowicz
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractIn the present work, we report a new series of potent SARS-CoV-2 Main Protease (Mpro) inhibitors based on maleimide derivatives. The inhibitory activities were tested in an enzymatic assay using recombinant Mpro (3CL Protease from coronavirus
Externí odkaz:
https://doaj.org/article/cdb6c235654144bfbb03ab8413a8952f
Autor:
Maja Przybyłowska, Krystyna Dzierzbicka, Szymon Kowalski, Sebastian Demkowicz, Mateusz Daśko, Iwona Inkielewicz-Stepniak
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1012-1022 (2022)
In this work, we designed, synthesised and biologically investigated a novel series of 14 N- and O-phosphorylated tacrine derivatives as potential anti-Alzheimer’s disease agents. In the reaction of 9-chlorotacrine and corresponding diamines/aminoa
Externí odkaz:
https://doaj.org/article/58e48df46aaa456083f2bc23928b953c
Autor:
Juliusz Maksymilian Walczak, Dorota Iwaszkiewicz-Grześ, Michalina Ziomkowska, Magdalena Śliwka-Kaszyńska, Mateusz Daśko, Piotr Trzonkowski, Grzegorz Cholewiński
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2725-2741 (2022)
The group of 18 new amide derivatives of mycophenolic acid (MPA) and selected heterocyclic amines was synthesised as potential immunosuppressive agents functioning as inosine-5′-monophosphate dehydrogenase (IMPDH) uncompetitive inhibitors. The synt
Externí odkaz:
https://doaj.org/article/498254b97d354c888722d7f34919fc29
Autor:
Olga Ciupak, Mateusz Daśko, Karol Biernacki, Janusz Rachon, Maciej Masłyk, Konrad Kubiński, Aleksandra Martyna, Sebastian Demkowicz
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 239-248 (2021)
In the present work, we report a new class of potent steroid sulphatase (STS) inhibitors based on 6-(1-phenyl-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives. Within the set of new STS inhibitors, 6-(1-(1,2,3-trifluorophenyl)-1H-1,2,3-tr
Externí odkaz:
https://doaj.org/article/1d8fdeadde00449b96ff653055b93fa6
Autor:
Mateusz Daśko, Sebastian Demkowicz, Karol Biernacki, Olga Ciupak, Witold Kozak, Maciej Masłyk, Janusz Rachon
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1163-1184 (2020)
The purpose of this review article is to provide an overview of recent achievements in the synthesis of novel steroid sulphatase (STS) inhibitors. STS is a crucial enzyme in the biosynthesis of active hormones (including oestrogens and androgens) and
Externí odkaz:
https://doaj.org/article/f089a2247d0c42ee9b6e9c28a518045c
Autor:
Angelika A. Adamus-Grabicka, Mateusz Daśko, Pawel Hikisz, Joachim Kusz, Magdalena Malecka, Elzbieta Budzisz
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 11, p 6061 (2022)
In this study, we evaluated the antiproliferative potential, DNA damage, crystal structures, and docking calculation of two spiropyrazoline derivatives. The main focus of the research was to evaluate the antiproliferative potential of synthesized com
Externí odkaz:
https://doaj.org/article/d616b3377c834243a3c754b08c61379b
Publikováno v:
Molecules, Vol 27, Iss 3, p 715 (2022)
Histone deacetylases (HDACs) are a large family of epigenetic metalloenzymes that are involved in gene transcription and regulation, cell proliferation, differentiation, migration, and death, as well as angiogenesis. Particularly, disorders of the HD
Externí odkaz:
https://doaj.org/article/28cd7ed2bb8f4c65b356cf75d261a784
Autor:
Sylwia Belica-Pacha, Mateusz Daśko, Vyacheslav Buko, Ilya Zavodnik, Katarzyna Miłowska, Maria Bryszewska
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 22, p 12357 (2021)
The interaction between sertraline hydrochloride (SRT) and randomly methylated β-cyclodextrin (RMβCD) molecules have been investigated at 298.15 K under atmospheric pressure. The method used—Isothermal Titration Calorimetry (ITC) enabled to deter
Externí odkaz:
https://doaj.org/article/c6b103e71a044f9bb59c222e259b487b
Autor:
Sylwia Belica-Pacha, Magdalena Małecka, Mateusz Daśko, Katarzyna Miłowska, Maria Bryszewska, Grażyna Budryn, Joanna Oracz, Bartłomiej Pałecz
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9419 (2021)
One tetracyclic antidepressant, mianserin hydrochloride (MIA), has quite significant side effects on a patients’ health. Cyclodextrins, which are most commonly used to reduce the undesirable features of contained drugs within their hydrophobic inte
Externí odkaz:
https://doaj.org/article/53cba216010247c78fb3a13fff845af6
Autor:
Mateusz Daśko, Anna Dołęga, Magdalena Siedzielnik, Karol Biernacki, Olga Ciupak, Janusz Rachon, Sebastian Demkowicz
Publikováno v:
Molecules, Vol 26, Iss 13, p 4059 (2021)
Herein, we present the synthesis and crystal structures determination of five 4-(1-phenyl-1H-1,2,3-triazol-4-yl)phenol derivatives containing halogen atoms, 6a–e, which may be used as an excellent mimic of steroids in the drug development process.
Externí odkaz:
https://doaj.org/article/aed464f0ec7e4020bc5648ce1c254479