Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Mateusz, Opyrchal"'
Autor:
Jessica Young, Pawel Kalinski, Mateusz Opyrchal, Kathleen M Kokolus, Sacha Gnjatic, Jianming Wang, Shipra Gandhi, Kristopher Attwood, Tracey O’Connor, Kazuaki Takabe, Victoria Fitzpatrick, Eduardo Cortes Gomez, Stephen Edge, Janine Miller, Ronald T Slomba, Ellis G Levine, Sinem Ozbey, Giorgio Ioannou, Cayla Janes, Igor De Souza, Vladimir Roudko, Prasanna Kumar, Suresh Kalathil, Helen Cappuccino
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 11 (2024)
Background Higher cytotoxic T lymphocyte (CTL) numbers in the tumor microenvironment (TME) predict pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) and positive long-term outcomes in triple-negative breast cancer (TNBC). pCR to NA
Externí odkaz:
https://doaj.org/article/d569717b5be14a588e378c08cde71fa3
Autor:
Dejan Juric, Minal Barve, Ulka Vaishampayan, Desamparados Roda, Aitana Calvo, Noelia Martinez Jañez, Jose Trigo, Alastair Greystoke, R. Donald Harvey, Anthony J. Olszanski, Mateusz Opyrchal, Alexander Spira, Fiona Thistlethwaite, Begoña Jiménez, Jessica Huck Sappal, Karuppiah Kannan, Jason Riley, Cheryl Li, Cong Li, Richard C. Gregory, Harry Miao, Shining Wang
Publikováno v:
Cancer Medicine, Vol 13, Iss 5, Pp n/a-n/a (2024)
Abstract Mivavotinib (TAK‐659/CB‐659), a dual SYK/FLT3 inhibitor, reduced immunosuppressive immune cell populations and suppressed tumor growth in combination with anti‐PD‐1 therapy in cancer models. This dose‐escalation/expansion study inv
Externí odkaz:
https://doaj.org/article/543c6b5130f7472f8fd3b9ea9ea6f7e2
Autor:
Stephanie L. Tzetzo, Elliot D. Kramer, Hemn Mohammadpour, Minhyung Kim, Spencer R. Rosario, Han Yu, Melissa R. Dolan, Chetan C. Oturkar, Brian G. Morreale, Paul N. Bogner, Aimee B. Stablewski, Fernando J. Benavides, Craig M. Brackett, John M.L. Ebos, Gokul M. Das, Mateusz Opyrchal, Michael J. Nemeth, Sharon S. Evans, Scott I. Abrams
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109187- (2024)
Summary: Tissue-resident macrophages (TRMs) are abundant immune cells within pre-metastatic sites, yet their functional contributions to metastasis remain incompletely understood. Here, we show that alveolar macrophages (AMs), the main TRMs of the lu
Externí odkaz:
https://doaj.org/article/b0dead588580421280f878bb0ac7259a
Autor:
Lauren Williams, Paul K Wallace, Pawel Kalinski, Mateusz Opyrchal, Kathleen M Kokolus, Shipra Gandhi, Kristopher Attwood, Agnieszka Witkiewicz, Hans Minderman, Kah Teong Soh, Melissa J Grimm, Ronald T Slomba, Adrienne Groman, Mary Lynne Tarquini, Orla Maguire, Tracey L O’Connor, Amy P Early, Ellis G Levine
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 11 (2023)
Background Presence of cytotoxic T lymphocytes (CTL) in the tumor microenvironment (TME) predicts the effectiveness of cancer immunotherapies. The ability of toll-like receptor 3 (TLR3) ligands, interferons (IFNs) and COX2 inhibitors to synergistical
Externí odkaz:
https://doaj.org/article/2d1ecf8be6c34222ae25dc9f47cf3dc6
Autor:
Brendan Curti, Igor Puzanov, Mateusz Opyrchal, Christopher J Nirschl, Mehmet A Bilen, Kristin Morris, Justin C Moser, Ildefonso Rodriguez Rivera, Saero Park, Marissa Bruno, Paul Windt, Kulandayan K Subramanian, Sameer S Chopra, Randi Isaacs
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/2c535f528fe849388924b327f27fc65e
Autor:
Foluso O. Ademuyiwa, Donald W. Northfelt, Tracey O’Connor, Ellis Levine, Jingqin Luo, Yu Tao, Jeremy Hoog, Marie L. Laury, Tracy Summa, Trish Hammerschmidt, Zhanfang Guo, Ashley Frith, Katherine Weilbaecher, Mateusz Opyrchal, Rebecca Aft, Katherine Clifton, Rama Suresh, Nusayba Bagegni, Ian S. Hagemann, Michael D. Iglesia, Cynthia X. Ma
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract Patients with ER+/HER2+ breast cancer (BC) are less likely to achieve pathological complete response (pCR) after chemotherapy with dual HER2 blockade than ER−/HER2+ BC. Endocrine therapy plus trastuzumab is effective in advanced ER+/HER2+
Externí odkaz:
https://doaj.org/article/49d5c74d8dba4b95b0b0ea0d7e2de4d4
Autor:
Zhuolong Zhou, Kevin Van der Jeught, Yujing Li, Samantha Sharma, Tao Yu, Ishara Moulana, Sheng Liu, Jun Wan, Paul R. Territo, Mateusz Opyrchal, Xinna Zhang, Guohui Wan, Xiongbin Lu
Publikováno v:
Advanced Science, Vol 10, Iss 23, Pp n/a-n/a (2023)
Abstract Pancreatic ductal adenocarcinoma (PDA) is a clinically challenging disease with limited treatment options. Despite a small percentage of cases with defective mismatch DNA repair (dMMR), PDA is included in the most immune‐resistant cancer t
Externí odkaz:
https://doaj.org/article/7fca9f29a3c545f6888c8ed0b4356d4e
Autor:
Eriko Katsuta, Mateusz Opyrchal
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/605b6e07445a4d05822fef4d4a57ad0b
Autor:
Sean H. Colligan, Andrea M. Amitrano, Robert A. Zollo, Jennifer Peresie, Elliot D. Kramer, Brian Morreale, Joseph Barbi, Prashant K. Singh, Han Yu, Jianmin Wang, Mateusz Opyrchal, David B. Sykes, Michael J. Nemeth, Scott I. Abrams
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 23 (2022)
While immune checkpoint inhibitors (ICIs) have transformed the therapeutic landscape in oncology, they are effective in select subsets of patients. Efficacy may be limited by tumor-driven immune suppression, of which 1 key mechanism is the developmen
Externí odkaz:
https://doaj.org/article/0a0122b323af493baa53eae9ada9561e
Autor:
Andrew A. Davis, Lorenzo Gerratana, Katherine Clifton, Arielle J. Medford, Marko Velimirovic, Whitney L. Hensing, Leslie Bucheit, Ami N. Shah, Paolo D'Amico, Carolina Reduzzi, Qiang Zhang, Charles S. Dai, Elyssa N. Denault, Nusayba A. Bagegni, Mateusz Opyrchal, Foluso O. Ademuyiwa, Ron Bose, William J. Gradishar, Amir Behdad, Cynthia X. Ma, Aditya Bardia, Massimo Cristofanilli
Publikováno v:
EBioMedicine, Vol 86, Iss , Pp 104316- (2022)
Summary: Background: Limited data exist to characterise molecular differences in circulating tumour DNA (ctDNA) for patients with invasive lobular carcinoma (ILC). We analysed metastatic breast cancer patients with ctDNA testing to assess genomic dif
Externí odkaz:
https://doaj.org/article/07b125b3c92b42acba72a92a3f8e5d48