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Anomalous AMPK-regulated angiotensin AT1R expression and SIRT1-mediated mitochondrial biogenesis at RVLM in hypertension programming of offspring to maternal high fructose exposure

Autor: Yung-Mei Chao, Kay L. H. Wu, Pei-Chia Tsai, You-Lin Tain, Steve Leu, Wei-Chia Lee, Julie Y. H. Chan

Publikováno v: Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-18 (2020)

Abstract Background Tissue oxidative stress, sympathetic activation and nutrient sensing signals are closely related to adult hypertension of fetal origin, although their interactions in hypertension programming remain unclear. Based on a maternal hi

Externí odkaz: https://doaj.org/article/ada45c778a214767aff495205233790e

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Protection by -Biotics against Hypertension Programmed by Maternal High Fructose Diet: Rectification of Dysregulated Expression of Short-Chain Fatty Acid Receptors in the Hypothalamic Paraventricular Nucleus of Adult Offspring

Autor: Yung-Mei Chao, Julie Y.H. Chan, Hong-Ren Yu, You-Lin Tain, Wei-Chia Lee, Kay L.H. Wu

Publikováno v: Nutrients; Volume 14; Issue 20; Pages: 4306

The role of short-chain fatty acids (SCFAs) in the brain on the developmental programming of hypertension is poorly understood. The present study explored dysregulated tissue levels of SCFAs and expression of SCFA-sensing receptors in the hypothalami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d9829611cb621694d52f9b4c92fa78c
https://doi.org/10.3390/nu14204306

Environmental Stimulation Counteracts the Suppressive Effects of Maternal High-Fructose Diet on Cell Proliferation and Neuronal Differentiation in the Dentate Gyrus of Adult Female Offspring via Histone Deacetylase 4

Autor: Mu-Hui Fu, Julie Y.H. Chan, Chih-Kuang Liang, You-Lin Tain, Chun-Ying Hung, Pi-Lien Hung, Hong-Ren Yu, Lee Wei Chen, Wen-Chung Liu, Kay L.H. Wu, Chih-Wei Wu, I-Chun Chen

Publikováno v: International Journal of Environmental Research and Public Health
Volume 17
Issue 11
International Journal of Environmental Research and Public Health, Vol 17, Iss 3919, p 3919 (2020)

Maternal high-fructose diets (HFD) impair the learning and memory capacity of adult female offspring via histone deacetylase 4 (HDAC4). Hippocampal adult neurogenesis is important for supporting the function of existing neural circuits. In this study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58595dccefaef09b8c39d7731c28b8d2