Zobrazeno 1 - 10
of 259
pro vyhledávání: '"Maternal embryonic leucine zipper kinase"'
Autor:
Dipranjan Laha, Robert R.C. Grant, Prachi Mishra, Myriem Boufraqech, Min Shen, Ya-Qin Zhang, Matthew D. Hall, Martha Quezado, Michelly Sampaio De Melo, Jaydira Del Rivero, Martha Zeiger, Naris Nilubol
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-16 (2022)
Abstract Background Adrenocortical cancer (ACC) is a rare and aggressive cancer with dismal 5-year survival due to a lack of effective treatments. We aimed to identify a new effective combination of drugs and investigated their synergistic efficacy i
Externí odkaz:
https://doaj.org/article/dedbd92387774c66a2f1443d619c0eaa
Computational exploration of maternal embryonic leucine zipper kinase (MELK) as a cancer drug target
Autor:
Nahlah Makki Almansour
Publikováno v:
Saudi Journal of Biological Sciences, Vol 29, Iss 7, Pp 103335- (2022)
Maternal embryonic leucine zipper kinase (MELK) is of vital importance due to its significant role in cancer development and its association with poor prognosis in different cancers. Here, we employed several computer aided drug design approaches to
Externí odkaz:
https://doaj.org/article/a79b375c57c947a7880536c0c68cb5c9
Autor:
Xu Zhang, Jie Wang, Yifeng Wang, Guanzheng Liu, Huan Li, Jiefeng Yu, Runqiu Wu, Jun Liang, Rutong Yu, Xuejiao Liu
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/72f0966e6c8345f7a5f7c9f5c8452fad
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-16 (2020)
Abstract Background Cervical cancer is the most prevalent gynecological malignancies accompanied by high mortality, where finding a more effective therapeutic option for cervical cancer is necessary. The inhibitory role of microRNAs (miRNAs) derived
Externí odkaz:
https://doaj.org/article/649eb4b34e2b45f0ba4a918ebba0cae4
Autor:
Xu Zhang, Jie Wang, Yifeng Wang, Guanzheng Liu, Huan Li, Jiefeng Yu, Runqiu Wu, Jun Liang, Rutong Yu, Xuejiao Liu
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Glioblastoma multiforme (GBM) is a devastating disease yet no effective drug treatment has been established to date. Glioblastoma stem-like cells (GSCs) are insensitive to treatment and may be one of the reasons for the relapse of GBM. Maternal embry
Externí odkaz:
https://doaj.org/article/4fa613d9ff674403808cee7244c8f256
Akademický článek
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Publikováno v:
Biochemical Genetics. 60:576-597
Colorectal cancer (CRC) is a malignant cancer with an increasing incidence. Circular RNA (circRNA) is recently found to participate in the regulation of CRC progression. However, the role of circ_0007031 in CRC malignant progression remains elusive.
Publikováno v:
Journal of Human Genetics
Breast cancer is a heterogeneous disease that develops through a multistep process via the accumulation of genetic/epigenetic alterations in various cancer-related genes. Current treatment options for breast cancer patients include surgery, radiother
Publikováno v:
Bulletin of the National Research Centre, Vol 45, Iss 1, Pp 1-20 (2021)
Background Cancer of the breast is known to be among the top spreading diseases on the globe. Triple-negative breast cancer is painstaking the most destructive type of mammary tumor because it spreads faster to other parts of the body, with high chan
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-18 (2021)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
BackgroundNon-small cell lung cancer (NSCLC) is a major histological subtype of lung cancer with high mortality and morbidity. A substantial amount of evidence demonstrates long non-coding RNAs (lncRNA) as critical regulators in tumorigeneis and mali