Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Matej Usaj"'
Autor:
Yuko Arita, Griffin Kim, Zhijian Li, Helena Friesen, Gina Turco, Rebecca Y Wang, Dale Climie, Matej Usaj, Manuel Hotz, Emily H Stoops, Anastasia Baryshnikova, Charles Boone, David Botstein, Brenda J Andrews, R Scott McIsaac
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 6, Pp 1-23 (2021)
Abstract The ability to switch a gene from off to on and monitor dynamic changes provides a powerful approach for probing gene function and elucidating causal regulatory relationships. Here, we developed and characterized YETI (Yeast Estradiol strain
Externí odkaz:
https://doaj.org/article/e823bfdfa6794a8b99835ae6fd0838ee
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 11, Pp 3969-3976 (2020)
Externí odkaz:
https://doaj.org/article/32e3139a2bdd4ebf9ebf61bffb2eba26
Autor:
Mojca Mattiazzi Usaj, Nil Sahin, Helena Friesen, Carles Pons, Matej Usaj, Myra Paz D Masinas, Ermira Shuteriqi, Aleksei Shkurin, Patrick Aloy, Quaid Morris, Charles Boone, Brenda J Andrews
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 2, Pp 1-27 (2020)
Abstract Our ability to understand the genotype‐to‐phenotype relationship is hindered by the lack of detailed understanding of phenotypes at a single‐cell level. To systematically assess cell‐to‐cell phenotypic variability, we combined auto
Externí odkaz:
https://doaj.org/article/7986b1484d9d4e6cac836c9b612e4d93
Autor:
Traver Hart, Amy Hin Yan Tong, Katie Chan, Jolanda Van Leeuwen, Ashwin Seetharaman, Michael Aregger, Megha Chandrashekhar, Nicole Hustedt, Sahil Seth, Avery Noonan, Andrea Habsid, Olga Sizova, Lyudmila Nedyalkova, Ryan Climie, Leanne Tworzyanski, Keith Lawson, Maria Augusta Sartori, Sabriyeh Alibeh, David Tieu, Sanna Masud, Patricia Mero, Alexander Weiss, Kevin R. Brown, Matej Usaj, Maximilian Billmann, Mahfuzur Rahman, Michael Constanzo, Chad L. Myers, Brenda J. Andrews, Charles Boone, Daniel Durocher, Jason Moffat
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 8, Pp 2719-2727 (2017)
The adaptation of CRISPR/SpCas9 technology to mammalian cell lines is transforming the study of human functional genomics. Pooled libraries of CRISPR guide RNAs (gRNAs) targeting human protein-coding genes and encoded in viral vectors have been used
Externí odkaz:
https://doaj.org/article/d4b448c162324c49bda2645179b12775
Autor:
Matej Usaj, Yizhao Tan, Wen Wang, Benjamin VanderSluis, Albert Zou, Chad L. Myers, Michael Costanzo, Brenda Andrews, Charles Boone
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 5, Pp 1539-1549 (2017)
Providing access to quantitative genomic data is key to ensure large-scale data validation and promote new discoveries. TheCellMap.org serves as a central repository for storing and analyzing quantitative genetic interaction data produced by genome-s
Externí odkaz:
https://doaj.org/article/8d6661a9770d4d72b591bcb9c7ff28de
Autor:
Barbara Mair, Jelena Tomic, Sanna N. Masud, Peter Tonge, Alexander Weiss, Matej Usaj, Amy Hin Yan Tong, Jamie J. Kwan, Kevin R. Brown, Emily Titus, Michael Atkins, Katherine S.K. Chan, Lise Munsie, Andrea Habsid, Hong Han, Marion Kennedy, Brenda Cohen, Gordon Keller, Jason Moffat
Publikováno v:
Cell Reports, Vol 27, Iss 2, Pp 599-615.e12 (2019)
Summary: Human pluripotent stem cells (hPSCs) provide an invaluable tool for modeling diseases and hold promise for regenerative medicine. For understanding pluripotency and lineage differentiation mechanisms, a critical first step involves systemati
Externí odkaz:
https://doaj.org/article/b48e7be0191349729bde89c8056e0021
Autor:
Sergey V. Venev, Athma A. Pai, Matej Usaj, Katherine S. K. Chan, Barbara Mair, Amy Hin Yan Tong, Jason Moffat, Eraj Khokhar, Job Dekker, Anne-Laure Valton
Publikováno v:
Nat Struct Mol Biol
SUMMARYCohesin-mediated loop extrusion folds interphase chromosomes at the ten to hundreds kilobases scale. This process produces structural features such as loops and topologically associating domains. We identify three types of cis-elements that de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707f36c9ae1b2c5f86f9ff94cbb3fd01
https://doi.org/10.1038/s41594-022-00890-9
https://doi.org/10.1038/s41594-022-00890-9
Autor:
Brenda J. Andrews, Charles Boone, Quaid Morris, Patrick Aloy, Aleksei Shkurin, Ermira Shuteriqi, Myra Paz David Masinas, Matej Usaj, Carles Pons, Helena Friesen, Nil Sahin, Mojca Mattiazzi Usaj
Our ability to understand the genotype-to-phenotype relationship is hindered by the lack of detailed understanding of phenotypes at a single-cell level. To systematically assess cell-to-cell phenotypic variability, we combined automated yeast genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4505e863eaa31d61b4a9b49192895d13
https://doi.org/10.32920/22149032.v1
https://doi.org/10.32920/22149032.v1
Autor:
Maximillian Billmann, Zhen Yuan Lin, Katherine Chan, Kevin R. Brown, Chad L. Myers, Mahfuzur Rahman, Amy Hin Yan Tong, Lucy Nedyalkova, Charles Boone, Hala Abdouni, Keith A. Lawson, Michael Costanzo, Alexander Weiss, Andrea Habsid, Cassandra J. Wong, Jason Moffat, Brenda J. Andrews, Patricia Mero, Olga Sizova, James W. Dennis, Anne-Claude Gingras, Judy Pawling, Matej Usaj, Michael Aregger, Catherine Ross
Publikováno v:
Nature metabolism
The de novo synthesis of fatty acids has emerged as a therapeutic target for various diseases, including cancer. Because cancer cells are intrinsically buffered to combat metabolic stress, it is important to understand how cells may adapt to the loss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53dc33a202fc94ae5c2a2cb90d35e89a
https://doi.org/10.1038/s42255-020-0211-z
https://doi.org/10.1038/s42255-020-0211-z
Autor:
Elizabeth N. Koch, Catherine Ross, Bryan Joseph San Luis, Brenda J. Andrews, Michael Costanzo, Carles Pons, Chad L. Myers, Benjamin VanderSluis, Vincent Messier, Patrick Aloy, Matej Usaj, Charles Boone, Emira Shuteriqi, Mahfuzur Rahman, Justin Nelson, Wen Wang, Jing Hou
Publikováno v:
Science
Environmental impacts on gene networks A phenotype can be affected by genes interacting with other genes, the environment, or both other genes and the environment (a differential interaction). To better understand how these interactions function in y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba40cb2b299076333691f88ae0666239
https://doi.org/10.1126/science.abf8424
https://doi.org/10.1126/science.abf8424