Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Matej Janežič"'
Autor:
Barbara Herlah, Matej Janežič, Iza Ogris, Simona Golič Grdadolnik, Katja Kološa, Sonja Žabkar, Bojana Žegura, Andrej Perdih
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116676- (2024)
The molecular nanomachine, human DNA topoisomerase IIα, plays a crucial role in replication, transcription, and recombination by catalyzing topological changes in the DNA, rendering it an optimal target for cancer chemotherapy. Current clinical topo
Externí odkaz:
https://doaj.org/article/84def9e8971e4b6086da3e4625586de0
Autor:
Matej Janežič, Katja Valjavec, Kaja Bergant Loboda, Barbara Herlah, Iza Ogris, Mirijam Kozorog, Marjetka Podobnik, Simona Golič Grdadolnik, Gerhard Wolber, Andrej Perdih
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13474 (2021)
In this study, we utilized human DNA topoisomerase IIα as a model target to outline a dynophore-based approach to catalytic inhibitor design. Based on MD simulations of a known catalytic inhibitor and the native ATP ligand analog, AMP-PNP, we derive
Externí odkaz:
https://doaj.org/article/d9e7b114d1e74972aed9ab20e7944e36
Publikováno v:
Proceedings, Vol 22, Iss 1, p 78 (2019)
Cancer constitutes a group of diseases linked to abnormal cell growth that can potentially spread to other parts of the body and is one of the most common causes of death. [...]
Externí odkaz:
https://doaj.org/article/881781a6f6464cac8bd1690d1a786004
Publikováno v:
Journal of chemical information and modeling, vol. 62, no. 16, 2022.
Human DNA topoisomerase IIα is a biological nanomachine that regulates the topological changes of the DNA molecule and is considered a prime target for anticancer drugs. Despite intensive research, many atomic details about its mechanism of action r
Publikováno v:
Journal of Cellular Biochemistry. 122:787-800
Missense mutations of human choline acetyltransferase (CHAT) are mainly associated with congenital myasthenic syndrome (CMS). To date, several pathogenic mutations have been reported, but due to the rarity and genetic complexity of CMS and difficult
Autor:
Murali Aarthy, Bidisha Acharya, Priyanka Aggarwal, Nabeel Ahmad, Natarajan Aiswarya, Hakan Alici, Khattab Al-Khafaji, Anshul Assaiya, Saurabh Bansal, Suparna Bhar, Aparna Bhardwaj, Dhiraj Bhatia, Neel Sarovar Bhavesh, Joanna Bons, Krishnananda Chattopadhyay, Purna Bahadur Chetri, Orkid Coskuner-Weber, Soumya De, Veronica Isabel Dodero, Jack A. Elias, Agusti Emperador, Roberto Giambruno, Marco Giampà, Rajanish Giri, Steffen P. Graether, Akshita Gupta, Smita Gupta, Md Anzarul Haque, Orkun Hasekioglu, Md Imtaiyaz Hassan, Prajna N. Hebbar, A. Hema Naveena, Maria Georgina Herrera, Alexander-Maurice Illig, Asimul Islam, Matej Janežič, Jeyaraman Jeyakanthan, Suchitra Kamle, Kota Kasahara, Punit Kaur, Heena Khan, Janesh Kumar, Prateek Kumar, Ritesh Kumar, Saravanan Kumar, Vijay Kumar, Pooja Kumari, Varsha Kumari, Bishwajit Kundu, Chun Geun Lee, Dawei Li, Xubo Lin, Snigdha Maiti, Narattam Mandal, Anil Mhashal, Parul Mishra, Ajitha Mohan, Sandip Mukherjee, Sunandan Mukherjee, Niharika Nag, Koomity V. Nageswar, Fouzia Nasim, Santoshi Nayak, Siddharth Neog, Chandran Nithin, Amy O’Broin, Olujide O. Olubiyi, Laura Orellana, Aditya K. Padhi, Amrita Arpita Padhy, Dipak N. Patil, Vijay Kumar Prajapati, Insaf Ahmed Qureshi, Chandrashekar Narayanan Rahul, Anjali Rajwar, Kristijan Ramadan, S. Rashmi, Tadi Sai Ratnakar, Arun Kumar Rawat, Jacob Rose, Anwesha Roy, Jakob Rupert, Subhashree Sahoo, Nikita V. Saibo, Suman Samantray, Nikhil H. Samarth, Madhumathi Sanjeevi, Achinta Sannigrahi, Santanu Sasidharan, Prakash Saudagar, Birgit Schilling, Kanagaraj Sekar, Mansi Sharma, Pradeep Sharma, Sujata Sharma, Vinita Sharma, Kummari Shivani, Abhay Narayan Singh, Anamika Singh, Appu K. Singh, Meenakshi Singh, Sanjeev Kumar Singh, Satyendra Singh, Shailza Singh, Shalini Singh, Sudhir Kumar Singh, Tej P. Singh, Tugba Taskin-Tok, Arianne L. Theiss, Nicolo Tonali, Timir Tripathi, Vishal Trivedi, Vladimir N. Uversky, Payal Vaswani, K. Venuprasad, Elsa Zacco, Kam Y.J. Zhang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ebc2116dc18e4be848d6c848acde5d9
https://doi.org/10.1016/b978-0-323-90264-9.09988-8
https://doi.org/10.1016/b978-0-323-90264-9.09988-8
Autor:
Stane Pajk, Kaja Bergant, Bojana Žegura, Katja Valjavec, Metka Filipič, Matej Janežič, Izidor Sosič, Andrej Perdih, Martina Štampar, Stanislav Gobec
Publikováno v:
European Journal of Medicinal Chemistry. 175:330-348
Human DNA topoisomerases represent one of the key targets of modern chemotherapy. An emerging group of catalytic inhibitors of human DNA topoisomerase IIα comprises a new paradigm directed to circumvent the known limitations of topoisomerase II pois
Autor:
Metka Filipič, Martina Štampar, Andrej Perdih, Bojana Žegura, Kaja Bergant Loboda, Matej Janežič
Publikováno v:
Journal of Chemical Information and Modeling
Journal of chemical information and modeling, vol. 60, no. 7, pp. 3662-3678, 2020.
Journal of chemical information and modeling, vol. 60, no. 7, pp. 3662-3678, 2020.
Human type II topoisomerases, molecular motors that alter the DNA topology, are a major target of modern chemotherapy. Groups of catalytic inhibitors represent a new approach to overcome the known limitations of topoisomerase II poisons such as cardi
Publikováno v:
Computers & Education. 118:56-69
In this paper we present a new approach for modeling a learning organization using molecular network framework. For the purpose of this study, we have developed a new FUTURE-O-DYN model for simulation of learning organization by combining the FUTURE-
Publikováno v:
ChemistrySelect. 2:480-488
Catalytic inhibitors represent an attractive possibility of revisiting the established anticancer target human DNA topoisomerase IIα, taking advantage of the many different inhibition steps in its catalytic cycle. In this study we present our effort