Výsledky vyhledávání - "Matej Horvath"

Akademický článek

14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites

Autor: Matej Horvath, Olivia Petrvalska, Petr Herman, Veronika Obsilova, Tomas Obsil

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)

Horvath et al. structurally and biochemically characterize the full-length human DAPK2-14-3-3 complex to investigate the effects of binding to DAPK2 on its dimerization, activation by dephosphorylation of Ser318, and Ca2+/calmodulin binding. Their re

Externí odkaz: https://doaj.org/article/b760ecb751c143968c2d8af2223e83c8

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Lengthening the Guanidine–Aryl Linker of Phenylpyrimidinylguanidines Increases Their Potency as Inhibitors of FOXO3-Induced Gene Transcription

Autor: Klara Kohoutova, Vojtěch Dočekal, Michael J. Ausserlechner, Nora Kaiser, Andrej Tekel, Raju Mandal, Matej Horvath, Veronika Obsilova, Jan Vesely, Judith Hagenbuchner, Tomas Obsil

Publikováno v: ACS Omega. 7:34632-34646

Increased FOXO3 nuclear localization is involved in neuroblastoma chemoresistance and tumor angiogenesis. Accordingly, FOXO3 inhibition is a promising strategy for boosting antitumor immune responses and suppressing FOXO3-mediated therapy resistance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dda95a2e0a4642aa5af146779455398
https://doi.org/10.1021/acsomega.2c04613

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FOXO4 interacts with p53 TAD and CRD and inhibits its binding to DNA

Autor: Raju Mandal, Klara Kohoutova, Olivia Petrvalska, Matej Horvath, Pavel Srb, Vaclav Veverka, Veronika Obsilova, Tomas Obsil

Publikováno v: Protein Sci

Transcription factor p53 protects cells against tumorigenesis when subjected to various cellular stresses. Under these conditions, p53 interacts with transcription factor Forkhead box O (FOXO) 4, thereby inducing cellular senescence by upregulating t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b06a2218f77da4470582b652fd55a0d
https://doi.org/10.1002/pro.4287

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14‐3‐3 protein binding blocks the dimerization interface of caspase‐2

Autor: Veronika Obsilova, Olivia Petrvalska, Frantisek Filandr, Dana Kalabova, Tomas Obsil, Miroslava Alblova, Matej Horvath, Petr Man

Publikováno v: The FEBS Journal. 287:3494-3510

Among all species, caspase-2 (C2) is the most evolutionarily conserved caspase required for effective initiation of apoptosis following death stimuli. C2 is activated through dimerization and autoproteolytic cleavage and inhibited through phosphoryla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5572cfa84538f4ab1a4f8ebefe2e2d
https://doi.org/10.1111/febs.15215

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14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites

Autor: Matej, Horvath, Olivia, Petrvalska, Petr, Herman, Veronika, Obsilova, Tomas, Obsil

Publikováno v: Communications biology 4(1), 986 (1-14) (2021). doi:10.1038/s42003-021-02518-y
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology

Communications biology 4(1), 986 (1-14) (2021). doi:10.1038/s42003-021-02518-y
Death-associated protein kinase 2 (DAPK2) is a CaM-regulated Ser/Thr protein kinase, involved in apoptosis, autophagy, granulocyte differentiation and motility regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57100261c28451bc4142d7cfccb2e8c
https://bib-pubdb1.desy.de/record/465582

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Molecular Basis of 14‐3‐3 Protein Dependent Regulation of Caspase‐2

Autor: Dana Kalabova, Tomas Obsil, Frantisek Filandr, Miroslava Alblova, Matej Horvath, Petr Man, Veronika Obsilova, Olivia Petrvalska

Publikováno v: The FASEB Journal. 34:1-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5afaa094edf61466adb04c3431da589c
https://doi.org/10.1096/fasebj.2020.34.s1.02861

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The silent information regulator 1 (Sirt1) is a positive regulator of the Notch pathway in Drosophila

Autor: Zorana Mihajlovic, Yuri M. Moshkin, Raquel Perez-Gomez, Matej Horvath, Alena Krejci, Vera Slaninova

Publikováno v: The Biochemical journal. 473(22)

The silent information regulator 1 (Sirt1) has been shown to have negative effects on the Notch pathway in several contexts. We bring evidence that Sirt1 has a positive effect on Notch activation in Drosophila, in the context of sensory organ precurs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5bab570a74636f870f41d4f970a4d30
https://pubmed.ncbi.nlm.nih.gov/27623778

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