Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Matej Adámik"'
Autor:
Robert Helma, Pavla Bažantová, Marek Petr, Matej Adámik, Daniel Renčiuk, Vlastimil Tichý, Alena Pastuchová, Zuzana Soldánová, Petr Pečinka, Richard P. Bowater, Miroslav Fojta, Marie Brázdová
Publikováno v:
Molecules, Vol 24, Iss 11, p 2078 (2019)
Expansions of trinucleotide repeats (TNRs) are associated with genetic disorders such as Friedreich’s ataxia. The tumor suppressor p53 is a central regulator of cell fate in response to different types of insults. Sequence and structure-selective m
Externí odkaz:
https://doaj.org/article/70db4fdf9c134e1897137d5b357ca167
Autor:
Marie Brázdová, Vlastimil Tichý, Robert Helma, Pavla Bažantová, Alena Polášková, Aneta Krejčí, Marek Petr, Lucie Navrátilová, Olga Tichá, Karel Nejedlý, Martin L Bennink, Vinod Subramaniam, Zuzana Bábková, Tomáš Martínek, Matej Lexa, Matej Adámik
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167439 (2016)
Triplex DNA is implicated in a wide range of biological activities, including regulation of gene expression and genomic instability leading to cancer. The tumor suppressor p53 is a central regulator of cell fate in response to different type of insul
Externí odkaz:
https://doaj.org/article/b3f101886c88485e8b58765be1c7d627
Autor:
Marie Brázdová, Lucie Navrátilová, Vlastimil Tichý, Kateřina Němcová, Matej Lexa, Roman Hrstka, Petr Pečinka, Matej Adámik, Borivoj Vojtesek, Emil Paleček, Wolfgang Deppert, Miroslav Fojta
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59567 (2013)
Hot spot mutant p53 (mutp53) proteins exert oncogenic gain-of-function activities. Binding of mutp53 to DNA is assumed to be involved in mutp53-mediated repression or activation of several mutp53 target genes. To investigate the importance of DNA top
Externí odkaz:
https://doaj.org/article/98421fb53bf44268a1a6c6b347e71eca
Autor:
Petr Fajkus, Matej Adámik, Andrew D L Nelson, Agata M Kilar, Michal Franek, Michal Bubeník, Radmila Čapková Frydrychová, Alena Votavová, Eva Sýkorová, Jiří Fajkus, Vratislav Peška
Publikováno v:
Nucleic acids research.
In contrast to the catalytic subunit of telomerase, its RNA subunit (TR) is highly divergent in size, sequence and biogenesis pathways across eukaryotes. Current views on TR evolution assume a common origin of TRs transcribed with RNA polymerase II i
Autor:
Marek Petr, Marie Brázdová, Miroslav Fojta, Alena Pastuchová, Pavla Bažantová, Richard P. Bowater, Matej Adámik, Petr Pečinka, Vlastimil Tichý, Robert Helma, Daniel Renčiuk, Zuzana Soldánová
Publikováno v:
Molecules
Volume 24
Issue 11
Molecules, Vol 24, Iss 11, p 2078 (2019)
Volume 24
Issue 11
Molecules, Vol 24, Iss 11, p 2078 (2019)
Expansions of trinucleotide repeats (TNRs) are associated with genetic disorders such as Friedreich&rsquo
s ataxia. The tumor suppressor p53 is a central regulator of cell fate in response to different types of insults. Sequence and structure-se
s ataxia. The tumor suppressor p53 is a central regulator of cell fate in response to different types of insults. Sequence and structure-se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00276e22a3ee1b2f09344c265eefa218
https://ueaeprints.uea.ac.uk/id/eprint/71402/
https://ueaeprints.uea.ac.uk/id/eprint/71402/
Autor:
Marek Petr, Marie Brázdová, Pavla Bažantová, Daniel Renčiuk, Iva Kejnovská, Michaela Vorlíčková, Matej Adámik
Publikováno v:
Biochimie. :83-91
The tumor suppressor protein p53 is a key factor in genome stability and one of the most studied of DNA binding proteins. This is the first study on the interaction of wild-type p53 with guanine quadruplexes formed by the human telomere sequence. Usi
Autor:
Lucie Holaňová, Pavla Bažantová, Petr Pečinka, Vlastimil Tichý, Lucie Navrátilová, Alena Polášková, Matej Adámik, Marie Brázdová
Publikováno v:
Biochemical and Biophysical Research Communications. 456:29-34
Site-specific DNA recognition and binding activity belong to common attributes of all three members of tumor suppressor p53 family proteins: p53, p63 and p73. It was previously shown that heavy metals can affect p53 conformation, sequence-specific bi
Autor:
Matej Adámik, Marek Petr, Alena Polášková, Aneta Krejčí, Iva Kejnovská, Zuzana Dvořáková, Marie Brázdová, Lucie Navrátilová, Robert Helma, Michaela Vorlíčková
Publikováno v:
Bioscience Reports
We found that the p53 tumour suppressor protein binds specifically to the G-quadruplex DNA formed by MYC promoter sequence. We propose that p53 binding to G-quadruplexes can participate in regulation of p53 target genes.
G-quadruplexes are four-
G-quadruplexes are four-
Publikováno v:
Journal of Electroanalytical Chemistry. 848:113300
Methods which can distinguish between specific and non-specific protein interactions leading to the identification of hubs and nodes are still desired. This work shows utilization of chronopotentiometric stripping analysis in combination with a mercu
Autor:
Martin L. Bennink, Robert Helma, Olga Tichá, Matej Lexa, Marek Petr, Pavla Bažantová, Marie Brázdová, Vinod Subramaniam, Karel Nejedlý, Lucie Navrátilová, Vlastimil Tichý, Aneta Krejčí, Matej Adámik, Tomáš Martínek, Alena Polášková, Zuzana Bábková
Publikováno v:
PLoS ONE, 11(12). Public Library of Science
PLoS ONE, Vol 11, Iss 12, p e0167439 (2016)
PLoS ONE, 11(12):e0167439. Public Library of Science
Brázdová, M, Tichý, V, Helma, R, Bažantová, P, Polášková, A, Krejčí, A, Petr, M, Navrátilová, L, Tichá, O, Nejedlý, K, Bennink, M L, Subramaniam, V, Bábková, Z, Martínek, T, Lexa, M & Adámik, M 2016, ' p53 Specifically Binds Triplex DNA In Vitro and in Cells ', PLoS ONE, vol. 11, no. 12, pp. e0167439 . https://doi.org/10.1371/journal.pone.0167439
PLoS ONE
PLoS ONE, Vol 11, Iss 12, p e0167439 (2016)
PLoS ONE, 11(12):e0167439. Public Library of Science
Brázdová, M, Tichý, V, Helma, R, Bažantová, P, Polášková, A, Krejčí, A, Petr, M, Navrátilová, L, Tichá, O, Nejedlý, K, Bennink, M L, Subramaniam, V, Bábková, Z, Martínek, T, Lexa, M & Adámik, M 2016, ' p53 Specifically Binds Triplex DNA In Vitro and in Cells ', PLoS ONE, vol. 11, no. 12, pp. e0167439 . https://doi.org/10.1371/journal.pone.0167439
PLoS ONE
Triplex DNA is implicated in a wide range of biological activities, including regulation of gene expression and genomic instability leading to cancer. The tumor suppressor p53 is a central regulator of cell fate in response to different type of insul