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pro vyhledávání: '"Matea Rob"'
Autor:
Nikolina Prtenjaca, Matea Rob, Muhammad S. Alam, Andrea Markovinovic, Cristiana Stuani, Emanuele Buratti, Ivana Munitic
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 12, p 6829 (2022)
Mutations in optineurin, a ubiquitin-binding adaptor protein, cause amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease of motor neurons linked to chronic inflammation and protein aggregation. The majority of ALS patients, includin
Externí odkaz:
https://doaj.org/article/6a1832d3947d402ea9603aa034434013
Autor:
Beatrice Paola Festa, Farah H. Siddiqi, Maria Jimenez-Sanchez, Hyeran Won, Matea Rob, Alvin Djajadikerta, Eleanna Stamatakou, David C. Rubinsztein
In neurodegenerative diseases, microglia switch to an activated state, which results in excessive secretion of pro-inflammatory factors. Our work aims to investigate how this paracrine signaling affects neuronal function. Here, we show that activated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9179a9f5a4fa0cfae51048a9b30f2113
Publikováno v:
Current Opinion in Pharmacology
Autophagy is a lysosomal degradation pathway and the main clearance route of many toxic protein aggregates. The molecular pathology of Alzheimer's disease (AD) manifests in the form of protein aggregates—extracellular amyloid-β depositions and int
Publikováno v:
The Journal of Immunology. 206:52.22-52.22
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease marked by protein aggregation and neuroinflammation. Protein aggregates in >95% of ALS cases are cytoplasmic and contain ubiquitinated and phosphorylated TAR DNA binding protein 43 kD