Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Matan Thangavelu Thangavelu"'
Autor:
Ankur Sharma, Elaine Yiqun Cao, Vibhor Kumar, Xiaoqian Zhang, Hui Sun Leong, Angeline Mei Lin Wong, Neeraja Ramakrishnan, Muhammad Hakimullah, Hui Min Vivian Teo, Fui Teen Chong, Shumei Chia, Matan Thangavelu Thangavelu, Xue Lin Kwang, Ruta Gupta, Jonathan R. Clark, Giridharan Periyasamy, N. Gopalakrishna Iyer, Ramanuj DasGupta
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Drug resistance is one of the major causes of cancer-related deaths. Here, the authors using single cell RNA-seq of oral squamous cell carcinoma patient samples pre- and post-cisplatin treatment show that phenotypically homogenous cell populations di
Externí odkaz:
https://doaj.org/article/4c8180ac64824e05a63db761c9056b3c
Autor:
Joo-Leng Low, Dawn Pingxi Lau, Xiaoqian Zhang, Xue-Lin Kwang, Neha Rohatgi, Jane Vin Chan, Fui-Teen Chong, Stephen Qi Rong Wong, Hui-Sun Leong, Matan Thangavelu Thangavelu, Shivaji Rikka, Anders Martin Jacobsen Skanderup, Daniel Shao Weng Tan, Giridharan Periyasamy, Judice Lie Yong Koh, N Gopalakrishna Iyer, Ramanuj DasGupta
Publikováno v:
EBioMedicine, Vol 66, Iss , Pp 103297- (2021)
Externí odkaz:
https://doaj.org/article/efc7e7970bf04a188a2b4cbd40df635d
Autor:
Joo-Leng Low, Dawn Pingxi Lau, Xiaoqian Zhang, Xue-Lin Kwang, Neha Rohatgi, Jane Vin Chan, Fui-Teen Chong, Stephen Qi Rong Wong, Hui-Sun Leong, Matan Thangavelu Thangavelu, Shivaji Rikka, Anders Martin Jacobsen Skanderup, Daniel Shao Weng Tan, Giridharan Periyasamy, Judice Lie Yong Koh, N Gopalakrishna Iyer, Ramanuj DasGupta
Publikováno v:
EBioMedicine, Vol 64, Iss , Pp 103220- (2021)
Background: Overexpression of epidermal growth factor receptor (EGFR), and downstream pathway activation appears to be a common oncogenic driver in the majority of head and neck squamous cell cancers (HNSCCs); yet targeting EGFR for the treatment of
Externí odkaz:
https://doaj.org/article/a859aa922a95418fb03d43002f362811
Autor:
Tuan Zea Tan, Srinivasaraghavan Kannan, Lingzhi Wang, Thi Bich Uyen Le, Richard Weijie Ong, Giridharan Periyasamy, Chandra S. Verma, Nur Afiqah Binte Mohamed Salleh, Jane Vin Chan, Li Ren Kong, David P. Lane, Matan Thangavelu Thangavelu, Chit Fang Cheok, Wee Joo Chng, Chwee Ming Lim, Lie Yong Judice Koh, Jieying Amelia Lau, Ashok R. Venkitaraman, Miyoung Lee, Boon Cher Goh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Gain of function (GOF) DNA binding domain (DBD) mutations of TP53 upregulate chromatin regulatory genes that promote genome-wide histone methylation and acetylation. Here, we therapeutically exploit the oncogenic GOF mechanisms of p53 codon 158 (Arg1
Autor:
Raghuvaran Shanmugam, Mert Burak Ozturk, Joo-Leng Low, Semih Can Akincilar, Joelle Yi Heng Chua, Matan Thangavelu Thangavelu, Giridharan Periyasamy, Ramanuj DasGupta, Vinay Tergaonkar
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Mutations in hTERT promoter are seen in over 19% of human cancers, irrespective of the cancer type. Understanding the molecular players that regulate Mut-hTERT promoters may help the design of effective targeting strategies to inhibit te
Autor:
Matan Thangavelu Thangavelu, Hui Min Vivian Teo, Fui Teen Chong, Jonathan R. Clark, Ankur Sharma, Ruta Gupta, Muhammad Hakimullah, Giridharan Periyasamy, Vibhor Kumar, Elaine Yiqun Cao, Xue Lin Kwang, Neeraja Ramakrishnan, Hui Sun Leong, Shumei Chia, N. Gopalakrishna Iyer, Angeline Mei Lin Wong, Xiaoqian Zhang, Ramanuj DasGupta
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Chemo-resistance is one of the major causes of cancer-related deaths. Here we used single-cell transcriptomics to investigate divergent modes of chemo-resistance in tumor cells. We observed that higher degree of phenotypic intra-tumor heterogeneity (
Autor:
Neha Rohatgi, Hui-Sun Leong, Anders Jacobsen Skanderup, Stephen Qi Rong Wong, Giridharan Periyasamy, Matan Thangavelu Thangavelu, Judice Lie Yong Koh, Fui-Teen Chong, Xiaoqian Zhang, Ramanuj DasGupta, N. Gopalakrishna Iyer, Dawn Pingxi Lau, Daniel Shao Weng Tan, Jane Vin Chan, Xue-Lin Kwang, Joo-Leng Low, Shivaji Rikka
Publikováno v:
EBioMedicine
EBioMedicine, Vol 64, Iss, Pp 103220-(2021)
EBioMedicine, Vol 64, Iss, Pp 103220-(2021)
Background Overexpression of epidermal growth factor receptor (EGFR), and downstream pathway activation appears to be a common oncogenic driver in the majority of head and neck squamous cell cancers (HNSCCs); yet targeting EGFR for the treatment of H
Autor:
Patrick Tan, Giridharan Periyasamy, Matan Thangavelu Thangavelu, Judice L. Y. Koh, Hiang Khoon Tan, Shen Yon Toh, Daniel Shao-Weng Tan, Joo-Leng Low, Yan Su, Ankur Sharma, Thakshayeni Skanthakumar, Jacqueline S.G. Hwang, Alexander Lezhava, Iain Beehuat Tan, Hannes Hentze, Hui-Sun Leong, Shumei Chia, N. Gopalakrishna Iyer, Xue-Lin Kwang, Kok-Hing Lim, Xiaoqian Zhang, Ramanuj DasGupta, Siang Hui Choo, Fui-Teen Chong, Denis Bertrand
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications
Nature Communications
Genomics-driven cancer therapeutics has gained prominence in personalized cancer treatment. However, its utility in indications lacking biomarker-driven treatment strategies remains limited. Here we present a “phenotype-driven precision-oncology”
Autor:
May Yin Lee, Zhi Han Lim, Yun Shen Chan, Feng Li, Atsushi Suzuki, Edward Kai-Hua Chow, Glenn Kunnath Bonney, John M. Asara, Alicia Stein, Matan Thangavelu Thangavelu, Yoganathan Kanagasundaram, Tan Boon Toh, Guo-Dong Lu, Joanna Z. Yeo, Hong Kee Tan, Kol Jia Yong, Siyu Wang, Justin L. Tan, Chung Yan Leong, Yock Young Dan, Chan Shuo Wu, Giridharan Periyasamy, Zi Hui Tan, Bee Hui Liu, Siming Ma, Wai Leong Tam, Huck-Hui Ng, Guo Hao Ng, Siew Bee Ng, Lissa Hooi, Nikki R. Kong, Tim Chan, Daniel G. Tenen, Li Chai, Kia Ngee Low, Mahmoud A. Bassal, Yue Wu
Publikováno v:
Gastroenterology
Background & Aims Some oncogenes encode transcription factors, but few drugs have been successfully developed to block their activity specifically in cancer cells. The transcription factor SALL4 is aberrantly expressed in solid tumor and leukemia cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d870803882ebda006613d11fea7366ed
https://europepmc.org/articles/PMC7309153/
https://europepmc.org/articles/PMC7309153/
Autor:
Giridharan Periyasamy, Bee Hui Liu, Li Chai, Yue Wu, Kol Jia Yong, May Yin Lee, Siyu Wang, Glenn Kunath Bonney, Justin L. Tan, Yoganathan Kanagasundaram, Atsushi Suzuki, Yun Shen Chan, Zi Hui Tan, John M. Asara, Zhi Han Lim, Tan Boon Toh, Chan-Shuo Wu, Nikki R. Kong, Feng Li, Hon Man Chan, Yock Young Dan, Guo-Dong Lu, Edward Kai-Hua Chow, Alicia Stein, Wai Leong Tam, Huck-Hui Ng, Lissa Hooi, Guo Hao Ng, Siew Bee Ng, Joanna Z. Yeo, Chung Yan Leong, Daniel Geoffrey Tenen, Matan Thangavelu Thangavelu, Hong Kee Tan, Kia Ngee Low, Mahmoud A. Bassal, Siming Ma
Publikováno v:
Cancer Research. 80:1788-1788
Transcription factors are important drivers of cancer but the development of therapeutics against these factors has had limited success. We developed a stringent high-throughput chemical genetic screening platform to identify compounds that target on