Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Matan Arbel"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8646 (2024)
The fidelity of replication, especially in the presence of DNA damage, is essential for the proper function of cells. Mutations that inactivate genes involved in DNA damage repair or bypass are enriched in several types of cancer cells. Thus, it is i
Externí odkaz:
https://doaj.org/article/4061806ed0674fe5bdbeda98541debe0
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 6, p 3359 (2024)
DNA Damage Tolerance (DDT) mechanisms allow cells to bypass lesions in the DNA during replication. This allows the cells to progress normally through the cell cycle in the face of abnormalities in their DNA. PCNA, a homotrimeric sliding clamp complex
Externí odkaz:
https://doaj.org/article/d71a08ded0404a74a66622328efd3d45
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1568 (2023)
Timely and complete replication of the genome is essential for life. The PCNA ring plays an essential role in DNA replication and repair by contributing to the processivity of DNA polymerases and by recruiting proteins that act in DNA replication-ass
Externí odkaz:
https://doaj.org/article/2609b142bf3d44f884fdc5a47c298783
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT During DNA replication, stalling can occur when the replicative DNA polymerases encounter lesions or hard-to replicate regions. Under these circumstances, the processivity factor PCNA gets ubiquitylated at lysine 164, inducing the DNA damage
Externí odkaz:
https://doaj.org/article/c6fb9d83f3524b178fcfaa153a1f91ba
Publikováno v:
Genes, Vol 12, Iss 1812, p 1812 (2021)
Genes
Genes
During each cell duplication, the entirety of the genomic DNA in every cell must be accurately and quickly copied. Given the short time available for the chore, the requirement of many proteins, and the daunting amount of DNA present, DNA replication
Publikováno v:
FEMS microbiology reviews. 45(1)
What is the origin of mutations? In contrast to the naïve notion that mutations are unfortunate accidents, genetic research in microorganisms has demonstrated that most mutations are created by genetically encoded error-prone repair mechanisms. Howe
Publikováno v:
mBio, Vol 11, Iss 3, p e00705-20 (2020)
mBio
mBio, Vol 11, Iss 3 (2020)
mBio
mBio, Vol 11, Iss 3 (2020)
PCNA, the ring that encircles DNA maintaining the processivity of DNA polymerases, is modified by ubiquitin and SUMO. Whereas ubiquitin is required for bypassing lesions through the DNA damage tolerance (DDT) pathways, we show here that SUMOylation r
Publikováno v:
Current genetics. 66(5)
DNA polymerases sometimes stall during DNA replication at sites where DNA is damaged, or upon encounter with proteins or secondary structures of DNA. When that happens, the polymerase clamp PCNA can become modified with a single ubiquitin moiety at l
During DNA replication stalling can occur when the replicative DNA polymerases encounter lesions or hard-to replicate regions. Under these circumstances the processivity factor PCNA gets ubiquitylated at lysine 164, inducing the DNA damage tolerance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9632aa9fe89664c58f60ed2efb3f7f00
Publikováno v:
AIP Advances, Vol 6, Iss 2, Pp 025314-025314-8 (2016)
A simulation study and measurements of the electrical conductance in a PbSe and PbS spherical Nano-crystal 3D matrix layer was carried out focusing on its dependences of Nano-crystal size distribution and size gradient along the layer thickness (z-di
Externí odkaz:
https://doaj.org/article/db2a656d1c93444f9f0cf8af695c462f