Cytosolic and Acrosomal pH Regulation in Mammalian Sperm

Autor: Julio C. Chávez, Gabriela Carrasquel-Martínez, Sandra Hernández-Garduño, Arturo Matamoros Volante, Claudia L. Treviño, Takuya Nishigaki, Alberto Darszon

Publikováno v: Cells, Vol 13, Iss 10, p 865 (2024)

As in most cells, intracellular pH regulation is fundamental for sperm physiology. Key sperm functions like swimming, maturation, and a unique exocytotic process, the acrosome reaction, necessary for gamete fusion, are deeply influenced by pH. Sperm

Externí odkaz: https://doaj.org/article/e52fa18d2dd749298c48152739ed3527

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TRPV4 activity regulates nuclear Ca 2+ and transcriptional functions of β‐catenin in a renal epithelial cell model

Autor: Heidi Espadas-Álvarez, Jacqueline Martínez-Rendón, Isabel Larre, Angélica Rueda, Arturo Matamoros-Volante, Tamara Rosenbaum, Tatiana Romero-Garcia, Refugio García-Villegas

Publikováno v: Journal of Cellular Physiology. 236:3599-3614

TRPV4 is a nonselective cationic channel responsive to several physical and chemical stimuli. Defects in TRPV4 channel function result in human diseases, such as skeletal dysplasias, arthropathies, and peripheral neuropathies. Nonetheless, little is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0abc7a3814a8beeffbf2a451ceea278
https://doi.org/10.1002/jcp.30096

Hyperpolarization induces cytosolic alkalization of mouse sperm flagellum probably through sperm Na+/H+ exchanger

Autor: Sandra Hernández-Garduño, Julio C Chávez, Arturo Matamoros-Volante, Yoloxochitl Sánchez-Guevara, Paulina Torres, Claudia L Treviño, Takuya Nishigaki

Publikováno v: Reproduction (Cambridge, England). 164(4)

In brief Hyperpolarization of the membrane potential is a crucial step for mammalian sperm maturation. This work demonstrates that this membrane potential change likely activates a sperm-specific sodium/proton exchanger to induce alkalization in mous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fbf6947900585d119e015fe7aa2b15e
https://pubmed.ncbi.nlm.nih.gov/35900329

Sperm physiology varies according to ultradian and infradian rhythms

Autor: Ayelen Moreno-Irusta, Laura Cecilia Giojalas, Maria J. Figueras, Carlos A. N. Mercado, Héctor Alejandro Guidobaldi, Claudia L. Treviño, Jackelyn Melissa Kembro, Maria Noel Gallea, Esteban M. Domínguez, Nelso A. Paina, Rosa V. Molina, Ana Babini, Arturo Matamoros-Volante

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
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Scientific Reports

The spermatozoon must be physiologically prepared to fertilize the egg, process called capacitation. Human sperm samples are heterogeneous in their ability to capacitate themselves, which leads to variability between samples from the same or differen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8fe538839509fedbc2d71499585321
http://link.springer.com/article/10.1038/s41598-019-42430-4