Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Mataleena Parikka"'
Autor:
Milka Marjut Hammarén, Hanna Luukinen, Alina Sillanpää, Kim Remans, Karine Lapouge, Tânia Custódio, Christian Löw, Henna Myllymäki, Toni Montonen, Markus Seeger, Joseph Robertson, Tuula A. Nyman, Kirsi Savijoki, Mataleena Parikka
Publikováno v:
mSystems, Vol 8, Iss 3 (2023)
ABSTRACT The antibiotic-tolerant biofilms present in tuberculous granulomas add an additional layer of complexity when treating mycobacterial infections, including tuberculosis (TB). For a more efficient treatment of TB, the biofilm forms of mycobact
Externí odkaz:
https://doaj.org/article/501c037b6eb44b27a27fb1103b3d93a8
Publikováno v:
Cancers, Vol 15, Iss 24, p 5821 (2023)
Approximately 25% of children with B-cell precursor acute lymphoblastic leukemia (pB-ALL) harbor the t(12;21)(p13;q22) translocation, leading to the ETV6::RUNX1 (E::R) fusion gene. This translocation occurs in utero, but the disease is much less comm
Externí odkaz:
https://doaj.org/article/cd997880f31f4fa0bbc1aad83ea0375c
Autor:
Anni K Saralahti, Sanna-Kaisa E Harjula, Tommi Rantapero, Meri I E Uusi-Mäkelä, Mikko Kaasinen, Maiju Junno, Hannaleena Piippo, Matti Nykter, Olli Lohi, Samuli Rounioja, Mataleena Parikka, Mika Rämet
Publikováno v:
PLoS Genetics, Vol 19, Iss 1, p e1010586 (2023)
Streptococcus pneumoniae (pneumococcus) is one of the most frequent causes of pneumonia, sepsis and meningitis in humans, and an important cause of mortality among children and the elderly. We have previously reported the suitability of the zebrafish
Externí odkaz:
https://doaj.org/article/f53fb5fd72f74df4a0fa392e67b0badb
Autor:
Ashok Aspatwar, Milka Hammaren, Mataleena Parikka, Seppo Parkkila, Fabrizio Carta, Murat Bozdag, Daniela Vullo, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 65-71 (2020)
We investigated a panel of 14 compounds belonging to the monothiocarbamate (MTC) and dithiocarbamate (DTC) series against the β-carbonic anhydrase 3 (β-CA3) of Mycobacterium tuberculosis (Mtb). We also evaluated all compounds for toxicity using 1
Externí odkaz:
https://doaj.org/article/fcacb8f3654e4041b4b76e82ca83d910
Autor:
Kirsi Savijoki, Paola San-Martin-Galindo, Katriina Pitkänen, Minnamari Edelmann, Annika Sillanpää, Cim van der Velde, Ilkka Miettinen, Jayendra Z. Patel, Jari Yli-Kauhaluoma, Mataleena Parikka, Adyary Fallarero, Pekka Varmanen
Publikováno v:
Foods, Vol 12, Iss 1, p 90 (2022)
Disrupting bacterial quorum sensing (QS) signaling is a promising strategy to combat pathogenic biofilms without the development of antibiotic resistance. Here, we report that food-associated bacteria can interfere with the biofilm formation of a Gra
Externí odkaz:
https://doaj.org/article/556dfc00201844e498df96082efd4abb
Autor:
Kirsi Savijoki, Henna Myllymäki, Hanna Luukinen, Lauri Paulamäki, Leena-Maija Vanha-aho, Aleksandra Svorjova, Ilkka Miettinen, Adyary Fallarero, Teemu O. Ihalainen, Jari Yli-Kauhaluoma, Tuula A. Nyman, Mataleena Parikka
Publikováno v:
mSystems, Vol 6, Iss 3 (2021)
Mycobacteria are naturally resilient, and mycobacterial infections are notoriously difficult to treat with antibiotics, with biofilm formation being the main factor complicating the successful treatment of tuberculosis (TB). The present study shows t
Externí odkaz:
https://doaj.org/article/16725e605e6c4de2aaa60e074a5c7d62
Autor:
Ahmed Al-Samadi, Katja Tuomainen, Anne Kivimäki, Abdelhakim Salem, Sakhr Al-Kubati, Aini Hyytiäinen, Mataleena Parikka, Karri Mesimäki, Tommy Wilkman, Antti Mäkitie, Reidar Grenman, Tuula Salo
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-6 (2019)
Abstract Background Currently, in vivo model for personalised cancer drug testing is challenging. A zebrafish larvae xenograft model has been applied in recent years to cancer research, particularly for drug testing purposes, showing promising result
Externí odkaz:
https://doaj.org/article/82e9f47114a541f2941ddf4f5511e016
Autor:
Ashok Aspatwar, Holger M. Becker, Nanda Kumar Parvathaneni, Milka Hammaren, Aleksandra Svorjova, Harlan Barker, Claudiu T. Supuran, Ludwig Dubois, Philippe Lambin, Mataleena Parikka, Seppo Parkkila, Jean-Yves Winum
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1064-1073 (2018)
Carbonic anhydrase (CA) IX is a hypoxia inducible enzyme that is highly expressed in solid tumours. Therefore, it has been considered as an anticancer target using specific chemical inhibitors. The nitroimidazoles DTP338 and DTP348 have been shown to
Externí odkaz:
https://doaj.org/article/ee9b009ec2c749c69bb0b9778d5a058c
Autor:
Ashok Aspatwar, Milka Hammarén, Sanni Koskinen, Bruno Luukinen, Harlan Barker, Fabrizio Carta, Claudiu T. Supuran, Mataleena Parikka, Seppo Parkkila
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 832-840 (2017)
Inhibition of novel biological pathways in Mycobacterium tuberculosis (Mtb) creates the potential for alternative approaches for treating drug-resistant tuberculosis. In vitro studies have shown that dithiocarbamate-derived β-carbonic anhydrase (β-
Externí odkaz:
https://doaj.org/article/3713130df848413ea6187a1befd2b0f7
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 3 (2018)
Roughly one third of the human population carries a latent Mycobacterium tuberculosis infection, with a 5-10% lifetime risk of reactivation to active tuberculosis and further spreading the disease. The mechanisms leading to the reactivation of a late
Externí odkaz:
https://doaj.org/article/0674eb9a865949698e60407d6d1edb3d