Overcoming Limited Access to Virus Infection Rapid Testing: Development of a Lateral Flow Test for SARS-CoV-2 with Locally Available Resources

Autor: Estefanía S. Peri Ibáñez, Agostina Mazzeo, Carolina Silva, Maria Juliana Juncos, Guadalupe S. Costa Navarro, Horacio M. Pallarés, Virginia J. Wolos, Gabriel L. Fiszman, Silvia L. Mundo, Julio J. Caramelo, Marcelo J. Yanovsky, Matías Fingermann, Alejandro A. Castello, Andrea V. Gamarnik, Ana S. Peinetti, Daiana A. Capdevila

Publikováno v: Biosensors, Vol 14, Iss 9, p 416 (2024)

The COVID-19 pandemic highlighted testing inequities in developing countries. Lack of lateral flow test (LFT) manufacturing capacity was a major COVID-19 response bottleneck in low- and middle-income regions. Here we report the development of an open

Externí odkaz: https://doaj.org/article/9dc9f3d5a6334918b0ec18dc478aff3f

Biotechnological potential of Phospholipase D for Loxosceles antivenom development

Autor: Matías Fingermann, Adolfo Rafael de Roodt, Osvaldo Cascone, María Victoria Miranda

Publikováno v: Toxicon: X, Vol 6, Iss , Pp - (2020)

Loxoscelism is one of the most important forms of araneism in South America. The Health Authorities from countries with the highest incidence and longer history in registering loxoscelism cases indicate that specific antivenom should be administered

Externí odkaz: https://doaj.org/article/539e3ac668ea43a4892ce3eb450ebe9c

A simple and economic three-step process for producing highly purified Fab’ fragments directly from the egg yolk water-soluble fraction

Autor: Myriam Belén González Viacava, Carlos Leónidas Leiva, María Eugenia Tavarone, José Christian Dokmetjian, Osvaldo Cascone, Pablo Chacana, Matías Fingermann

Although mammals are still the main source of polyclonal antibodies production, the use of egg yolk immunoglobulins (IgY) is increasing, and thus improvement of its safety to reduce undesired reactions is needed. Removal of IgY constant domains by pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca511aa28681672024b5e52e35cff3e
https://biblio.vub.ac.be/vubir/a-simple-and-economic-threestep-process-for-producing-highly-purified-fab-fragments-directly-from-the-egg-yolk-watersoluble-fraction(28766dcc-c6d9-42d3-8bc6-2527efd61c86).html

Critical aspects on traditional antivenom production processes and their optimization by factorial analysis

Autor: Osvaldo Cascone, Matías Fingermann, Belén González Viacava, Eugenia Tavarone, Beatriz Norma Zurbano, J. Dokmetjian

Publikováno v: Biologicals. 68:65-73

Most antivenoms are produced by techniques developed over 50 years ago, with minor modifications. Herein we revise the core of traditional antivenom production processes aiming to optimize key determinants for both consistent antivenom production and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c22139472cd5b3549f9199400987ee10
https://doi.org/10.1016/j.biologicals.2020.08.005

Rapid and cost-effective process based on insect larvae for scale-up production of SARS-COV-2 spike protein for serological COVID-19 testing

Autor: Aldana Trabucchi, Matías Fingermann, Silvina Noemi Valdez, Osvaldo Cascone, María Gabriela López, Ruben F. Iacono, Susana Vázquez, Leonardo G. Alonso, Federico Javier Wolman, Silvina Sonia Bombicino, Joaquín Manuel Birenbaum, Juan Ignacio Marfía, Gregorio Juan Mc Callum, Juan Mauricio Minoia, María Victoria Miranda, Alexandra Marisa Targovnik, Oscar Taboga, Adriana Victoria Sabljic, Ignacio Smith

Publikováno v: Biotechnology and Bioengineering
Biotechnology and Bioengineering 118 (10) : 4129-4137 (October 2021)
INTA Digital (INTA)
Instituto Nacional de Tecnología Agropecuaria
instacron:INTA
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Serology testing for COVID‐19 is important in evaluating active immune response against SARS‐CoV‐2, studying the antibody kinetics, and monitoring reinfections with genetic variants and new virus strains, in particular, the duration of antibodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98a7c9692d222d13481d4dcbbb2e2639
https://pubmed.ncbi.nlm.nih.gov/34264519