Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Matías A. Ávila"'
Autor:
Carla Rojo, María Gárate-Rascón, Miriam Recalde, Ane Álava, María Elizalde, María Azkona, Iratxe Aldabe, Elisabet Guruceaga, Amaya López-Pascual, M Ujue Latasa, Bruno Sangro, Maite G. Fernández-Barrena, Matías A. Ávila, María Arechederra, Carmen Berasain
Publikováno v:
JHEP Reports, Vol 6, Iss 8, Pp 101118- (2024)
Background & Aims: The homeostasis of the cellular transcriptome depends on transcription and splicing mechanisms. Moreover, the fidelity of gene expression, essential to preserve cellular identity and function is secured by different quality control
Externí odkaz:
https://doaj.org/article/839678c118424464b7ef2ce1b0908674
Autor:
Kang Zheng, Fengjie Hao, Sandra Medrano-Garcia, Chaobo Chen, Feifei Guo, Laura Morán-Blanco, Sandra Rodríguez-Perales, Raúl Torres-Ruiz, María Isabel Peligros, Javier Vaquero, Rafael Bañares, Manuel Gómez del Moral, José R. Regueiro, Eduardo Martínez-Naves, Mohamed Ramadan Mohamed, Rocío Gallego-Durán, Douglas Maya, Javier Ampuero, Manuel Romero-Gómez, Albert Gilbert-Ramos, Sergi Guixé-Muntet, Anabel Fernández-Iglesias, Jordi Gracia-Sancho, Mar Coll, Isabel Graupera, Pere Ginès, Andreea Ciudin, Jesús Rivera-Esteban, Juan M. Pericàs, María Dolores Frutos, Bruno Ramos Molina, José María Herranz, Matías A. Ávila, Yulia A. Nevzorova, Edgar Fernández-Malavé, Francisco Javier Cubero
Publikováno v:
Cell Death and Disease, Vol 14, Iss 8, Pp 1-12 (2023)
Abstract Progressive hepatic damage and fibrosis are major features of chronic liver diseases of different etiology, yet the underlying molecular mechanisms remain to be fully defined. N-RAS, a member of the RAS family of small guanine nucleotide-bin
Externí odkaz:
https://doaj.org/article/01a591f664c741c59cc9c983321052fd
Autor:
Amaya Lopez-Pascual, Marc Cusachs, María Arechederra, Carmen Berasain, Matías A. Ávila, Maite G. Fernández-Barrena
Publikováno v:
Exploration of Digestive Diseases, Vol 1, Iss 2, Pp 80-96 (2022)
Caspases are key factors in the regulation of the apoptotic and/or inflammatory responses, both crucial in the pathogenesis of diverse diseases. Caspase-2 is the most evolutionary conserved albeit functionally poorly defined member of the caspase fam
Externí odkaz:
https://doaj.org/article/d92e9ff5315d42238b0b96d2e9861c93
Autor:
Hui Ye, Chaobo Chen, Hanghang Wu, Kang Zheng, Beatriz Martín-Adrados, Esther Caparros, Rubén Francés, Leonard J. Nelson, Manuel Gómez del Moral, Iris Asensio, Javier Vaquero, Rafael Bañares, Matías A. Ávila, Raúl J. Andrade, M. Isabel Lucena, Maria Luz Martínez-Chantar, Helen L. Reeves, Steven Masson, Richard S. Blumberg, Jordi Gracia-Sancho, Yulia A. Nevzorova, Eduardo Martínez-Naves, Francisco Javier Cubero
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-13 (2022)
Abstract Acetaminophen (APAP) hepatotoxicity induces endoplasmic reticulum (ER) stress which triggers the unfolded protein response (UPR) in hepatocytes. However, the mechanisms underlying ER stress remain poorly understood, thus reducing the options
Externí odkaz:
https://doaj.org/article/1cfd4329e56e47219aae65911f141a1f
Autor:
Daniel Jericó, Karol M. Córdoba, Lei Jiang, Caroline Schmitt, María Morán, Ana Sampedro, Manuel Alegre, María Collantes, Eva Santamaría, Estíbaliz Alegre, Corinne Culerier, Ander Estella-Hermoso de Mendoza, Julen Oyarzabal, Miguel A. Martín, Iván Peñuelas, Matías A. Ávila, Laurent Gouya, Paolo G.V. Martini, Antonio Fontanellas
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 25, Iss , Pp 207-219 (2021)
Variegate porphyria (VP) results from haploinsufficiency of protoporphyrinogen oxidase (PPOX), the seventh enzyme in the heme synthesis pathway. There is no VP model that recapitulates the clinical manifestations of acute attacks. Combined administra
Externí odkaz:
https://doaj.org/article/f0e88f862dcd434c9fb48ea42beb448a
Autor:
Miriam Longo, Daniel Jericó, Karol M. Córdoba, José Ignacio Riezu-Boj, Raquel Urtasun, Isabel Solares, Ana Sampedro, María Collantes, Ivan Peñuelas, María Jesús Moreno-Aliaga, Matías A. Ávila, Elena Di Pierro, Miguel Barajas, Fermín I. Milagro, Paola Dongiovanni, Antonio Fontanellas
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 11938 (2023)
Acute intermittent porphyria (AIP) is a metabolic disorder caused by mutations in the porphobilinogen deaminase (PBGD) gene, encoding the third enzyme of the heme synthesis pathway. Although AIP is characterized by low clinical penetrance (~1% of PBG
Externí odkaz:
https://doaj.org/article/4f05cfbbec6f45b288b2bf102e5b5aba
Autor:
Daniel Jericó, Karol M. Córdoba, Ana Sampedro, Lei Jiang, Gilles Joucla, Charlotte Cabanne, José Luis Lanciego, Paolo G. V. Martini, Pedro Berraondo, Matías A. Ávila, Antonio Fontanellas
Publikováno v:
Life, Vol 12, Iss 11, p 1858 (2022)
Rare diseases, especially monogenic diseases, which usually affect a single target protein, have attracted growing interest in drug research by encouraging pharmaceutical companies to design and develop therapeutic products to be tested in the clinic
Externí odkaz:
https://doaj.org/article/e85dc083829242d0a9443dcdb8a9237a
Autor:
María Gárate-Rascón, Miriam Recalde, Carla Rojo, Maite G. Fernández-Barrena, Matías A. Ávila, María Arechederra, Carmen Berasain
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13411 (2022)
SLU7 (Splicing factor synergistic lethal with U5 snRNA 7) was first identified as a splicing factor necessary for the correct selection of 3′ splice sites, strongly impacting on the diversity of gene transcripts in a cell. More recent studies have
Externí odkaz:
https://doaj.org/article/baa076ee88a54570b82ca350d497856b
Autor:
Sheila Maestro, Karol M. Córdoba, Cristina Olague, Josepmaria Argemi, Matías A. Ávila, Gloria González-Aseguinolaza, Cristian Smerdou, Antonio Fontanellas
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 137, Iss , Pp 111384- (2021)
Antiviral agents with different mechanisms of action could induce synergistic effects against SARS-CoV-2 infection. Some reports suggest the therapeutic potential of the heme oxygenase-1 (HO-1) enzyme against virus infection. Given that hemin is a na
Externí odkaz:
https://doaj.org/article/06c7ce1a5c244222b6eb2ffd0ababdb7
Autor:
Miriam Recalde, María Gárate-Rascón, José María Herranz, María Elizalde, María Azkona, Juan P. Unfried, Loreto Boix, María Reig, Bruno Sangro, Maite G. Fernández-Barrena, Puri Fortes, Matías A. Ávila, Carmen Berasain, María Arechederra
Publikováno v:
Cancers, Vol 14, Iss 9, p 2048 (2022)
Background: Long noncoding RNAs (lncRNAs) are emerging as key players in cancer, including hepatocellular carcinoma (HCC). Here we identify the mechanism implicated in the HCC inhibition of a set of lncRNAs, and their contribution to the process of h
Externí odkaz:
https://doaj.org/article/1e105d39c9164887aeea05b8fd9047eb