Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Masumi Asakura"'
In vitro chromosomal aberrations induced by various shapes of multi‐walled carbon nanotubes (MWCNTs)
Autor:
Taku Katagiri, Shoji Fukushima, Masumi Asakura, Tatsuya Kasai, Toshiaki Sasaki, Chigusa Ishioka
Publikováno v:
Journal of Occupational Health
Objectives IARC has classified one type of multi-walled carbon nanotubes (MWCNTs), MWNT-7, as possibly carcinogenic to humans (Group 2B); however, other types of MWCNT were categorized as not classifiable as to their carcinogenicity to humans (Group
Autor:
Nana Ishii, Sawako Kasamoto, Fukutaro Mizuhashi, Kamala Pant, Kumiko Hayashi, Kiyoshi Sasaki, Jamie E. Sly, Shannon W. Bruce, Noriho Tanaka, Hideki Hirose, Makoto Umeda, Shojiro Yamazaki, Ayako Sakai, Miho Nagai, Dai Muramatsu, Albrecht Poth, Shoko Arai, Sachiko Kuroda, Masumi Asakura, Nobuko Endou, Susanne Bohnenberger, Thorsten Kunkelmann
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 725:57-77
The Bhas 42 cell transformation assay is a sensitive short-term system for predicting chemical carcinogenicity. Bhas 42 cells were established from BALB/c 3T3 cells by the transfection of v-Ha-ras gene and postulated to have acquired an initiated sta
Autor:
Heihachiro Arito, Kasuke Nagano, Mitsutoshi Takaya, Masumi Asakura, Toshie Sugiyama, Shoji Fukushima, Shigeki Koda, Toshiaki Sasaki
Publikováno v:
Journal of Occupational Health. 52:155-166
Objectives: The potential applications and industrial production of multi-wall carbon nanotubes (MWCNT) have raised serious concerns about their safety for human health and the environment. The present study was designed to examine the in vitro cytot
Autor:
Shigetoshi Aiso, Kasuke Nagano, Hisayo Kubota, Masumi Asakura, Naoki Ikawa, Mitsutoshi Takaya, Shoji Fukushima, Heihachiro Arito, Kazunori Yamazaki, Fumio Serita
Publikováno v:
Industrial Health. 48:452-459
Much concern has been raised over the health consequences of workers exposed to carbon nanotubes. In order to characterize multi-wall carbon nanotubes (MWCNT) suspended in a phosphate-buffered saline containing 0.1% Tween 80 for an intratracheal inst
Autor:
Kazunori Yamazaki, Yumi Umeda, Masumi Asakura, Hirokazu Kano, Heihachiro Arito, Masaaki Suzuki, Kasuke Nagano, Michiharu Matsumoto, Shoji Fukushima
Publikováno v:
Journal of Occupational Health. 51:249-260
Objectives: This study was carried out to clarify the subchronic and chronic toxicity, and carcinogenicity of 2-amino-4-chlorophenol(ACP). Methods: Carcinogenicity, and chronic and subchronic toxicity of ACP were examined by feeding 10 rats of both s
Autor:
Shoji Fukushima, Toshiaki Sasaki, Toshie Sugiyama, Heihachiro Arito, Masumi Asakura, Taijiro Matsushima
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 652:122-130
A gas exposure system using rotating vessels was improved for exposure of cultured mammalian cells to gaseous compounds in the chromosomal aberration assay. This system was composed of 12 square culture vessels, a device for preparation of air contai
Autor:
Satoshi Sasaki, Kiyomi Ohmori, Tetsu Nakamura, Hidetoshi Oishi, Kiyoshi Sasaki, Shuichi Hamada, Shin Asada, Noriho Tanaka, Makoto Umeda, Eiji Yamamura, Satoshi Yajima, Toshiyuki Tsuchiya, Isao Yoshimura, Tomoko Yatsushiro, Yoshiyuki Nakamura, Yasuhito Yamamoto, Nobuko Kitou, Hiroki Takagi, Sawako Shimada, Masataka Washizuka, Harumi Araki, Ayako Sakai, Masumi Asakura, Yuichi Fushiwaki, Hiroshi Baba, Yoshifumi Uno
Publikováno v:
Alternatives to Laboratory Animals. 33:619-639
The Bhas promotion assay is a cell culture transformation assay designed as a sensitive and economical method for detecting the tumour-promoting activities of chemicals. In order to validate the transferability and applicability of this assay, an int
Autor:
Shinobu Wakuri, Fumio Mizuno, Yuko Takeda, Daisaku Miura, Shuichi Hamada, Chitose Takahashi, Shozo Ajimi, Youji Ebe, Nobuhiro Yajima, Sawako Shimada, Masayoshi Kawabata, Masumi Asakura, Toshiyuki Tsuchiya, Kaori Mashiko, Yuichi Fushiwaki, Yumiko Iwase, Isao Yoshimura, Yasuaki Dewa, Satoshi Yajima, Madoka Nakajima, Yoshitsugu Kajiwara, Emiko Kitada, Miho Sato, Fukutaro Mizuhashi, Hiroshi Nishiyama, Kinya Kubo, Noriho Tanaka, Toshie Sugiyama, Hiroshi Baba, Hidetoshi Oishi, Naoko Nobe, Chikako Toyoizumi, Yoshiyuki Nakamura, Ayako Sakai, Makoto Umeda, Tetsuo Hamamura, Makoto Hayashi, Takeki Tsutsui, Erina Ota, Yasushi Kasahara
Publikováno v:
Alternatives to laboratory animals : ATLA. 27(4)
The Non-genotoxic Carcinogen Study Group of the Environmental Mutagen Society of Japan organised the first step of an interlaboratory validation study on an improved cell transformation assay employing Balb/c 3T3 A31-1-1 cells. Nineteen laboratories
Autor:
Tatsuya Kasai, Yumi Umeda, Takamasa Kido, Hideki Senoh, Masashi Tsunoda, Masumi Asakura, Yoshiharu Aizawa, Shoji Fukushima, Hiroyuki Yanagisawa, Toshiaki Sasaki
Publikováno v:
Inhalation toxicology. 26(12)
The toxicity of multi-walled carbon nanotubes (MWCNT) may be related to the immune system. The objective of this study was to obtain information for immunotoxic mechanisms of MWCNT in situ.Using whole-body inhalation, male and female rats were expose
Autor:
K. Odawara, T. Noguchi, Noriho Tanaka, K. Watanabe, Yukimi Takahashi, Kohji Yamakage, Y. Kasahara, M. Hatanaka, S. Wakuri, S. Nakayama, Masaki Hara, Kunihiko F. Miura, Takeshi Morita, Hirokazu Kusakabe, H. Shimada, Makoto Hayashi, Motoi Ishidate, A. Matsuoka, Toshie Sugiyama, Masumi Asakura, Toshio Sofuni
Publikováno v:
Mutation Research/Genetic Toxicology. 369:243-252
In a collaborative study organized under the JEMS MMS, nine mouse lymphoma assay (MLA) "unique positive' NTP rodent carcinogens were re-evaluated by an in vitro chromosomal aberration assay using Chinese hamster lung fibroblast cells (CHL/IU). Six of