Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Masumi, Taki"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3525 (2023)
Monoclonal antibody therapies targeting immuno-modulatory targets such as checkpoint proteins, chemokines, and cytokines have made significant impact in several areas, including cancer, inflammatory disease, and infection. However, antibodies are com
Externí odkaz:
https://doaj.org/article/65370de06ff043bb939e6ac3765904c3
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7778 (2022)
A major obstacle to the therapeutic application of an aptamer is its susceptibility to nuclease digestion. Here, we confirmed the acquisition of relative nuclease resistance of a DNA-type thrombin binding aptamer with a warhead (TBA3) by covalent bin
Externí odkaz:
https://doaj.org/article/b27eda1322da42748394efcc5cad9418
Autor:
Riku, Katsuki, Tsubasa, Numayama, Yudai, Tabuchi, Jaiyam, Sharma, Naohito, Satake, Adarsh, Sandhu, Masumi, Taki
Publikováno v:
Analytical and Bioanalytical Chemistry. 414:4803-4807
We have previously established a selection system to obtain a solvatochromic protein binder from a peptidic fluoroprobe library via the extended T7 phage display. Here, we use the peptidic binder as a fluororeporter in this proof-of-concept study of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0be8257453c9b6cab51df35eeb207f
https://doi.org/10.1007/s00216-022-04128-x
https://doi.org/10.1007/s00216-022-04128-x
Akademický článek
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Publikováno v:
Molecules, Vol 19, Iss 2, Pp 2481-2496 (2014)
We have achieved site-specific conjugation of several haloacetamide derivatives into designated cysteines on bacteriophage T7-displayed peptides, which are fused to T7 capsid protein gp10. This easiest gp10 based-thioetherification (10BASEd-T) underg
Externí odkaz:
https://doaj.org/article/ac72260a2b884aa4b2f2a6403447a7df
Publikováno v:
Chemical Communications. 57(20):2483-2486
Alleviating the potential risk of irreversible adverse drug effects has been an important and challenging issue for the development of covalent drugs. Here we created a DNA-aptamer-type covalent drug by introducing a sulfonyl fluoride warhead at appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::084ae0e17522aa6975f0145f13a678cc
http://id.nii.ac.jp/1438/00009979/
http://id.nii.ac.jp/1438/00009979/
Publikováno v:
Organic & Biomolecular Chemistry. 19:146-150
We designed and synthesized a medium-firm drug-candidate library of cryptand-like structures possessing a randomized peptide linker on the bacteriophage T7. From the macrocyclic library with a 10^9 diversity, we obtained a binder toward a cancer-rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31501bec99b5be7b5798eeb0c423a46
https://doi.org/10.1039/d0ob01855d
https://doi.org/10.1039/d0ob01855d
Autor:
Yuji Ito, Tetsuya Kadonosono, Shinichi Sato, Maika Kitazawa, Takahiro Kuchimaru, Tadashi Shiozawa, Masumi Taki, Yumi Ota, Shinae Kizaka-Kondoh, Hiroyuki Nakamura, Wanaporn Yimchuen
Publikováno v:
RSC Advances. 10:15154-15162
Tumor-binding peptides such as human epidermal growth factor receptor 2 (HER2)-binding peptides are attractive therapeutic and diagnostic options for cancer. However, the HER2-binding peptides (HBPs) developed thus far are susceptible to proteolysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ae36a4f9759430d8876a5a04465236
https://doi.org/10.1039/d0ra00427h
https://doi.org/10.1039/d0ra00427h
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 11, p 3682 (2018)
To determine the binding-site of a combinatorially-selected peptide possessing a fluoroprobe, a novel cysteine reactive small photo-crosslinker that can be excited by a conventional long-wavelength ultraviolet handlamp (365 nm) was synthesized via Su
Externí odkaz:
https://doaj.org/article/06504aca3fd14ca79db5fad3d429190d
Publikováno v:
Chemical communications (Cambridge, England). 57(44)
A peptide-type covalent binder for a target protein was obtained by direct and stringent screening of a warhead-modified peptide library on the robust T7 phage. The aryl fluorosulfate (fosylate) warhead was activated only in a matchmaking microenviro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a33309f854c1106c187ba3ff7656bfea
https://pubmed.ncbi.nlm.nih.gov/33978001
https://pubmed.ncbi.nlm.nih.gov/33978001