Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Masterson LA"'
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4
Periodical
Synthesis of Precursors of Novel Morphinan Analogues
Autor: Masterson, LA, Proctor, G R, Midgley, J M
Publikováno v: Journal of Pharmacy and Pharmacology; December 1990, Vol. 42 Issue: 1, Number 1 Supplement 1 p38P-38P, 1p
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5
Akademický článek
Efficacy, Tolerability, and Pharmacokinetic Studies of Antibody-Drug Conjugates Containing a Low-Potency Pyrrolobenzodiazepine Dimer.
Autor: Gregson SJ; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom., Pugh K; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom., Patel N; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom., Afif-Rider S; AstraZeneca, One Medimmune Way, Gaithersburg, Maryland., Vijayakrishnan B; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom., Santos K; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom., Riedl J; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom., Hutchinson I; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom., Kang GD; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom., Chooi KP; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom., Beard R; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom., Adams L; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom., Barry CS; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom., Ball K; AstraZeneca, Granta Park, Cambridge, United Kingdom., Masterson LA; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom., McFarlane M; AstraZeneca, Granta Park, Cambridge, United Kingdom., Hartley JA; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom., Howard PW; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom.
Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2022 Sep 06; Vol. 21 (9), pp. 1439-1448.
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6
Akademický článek
Resistance to Pyrrolobenzodiazepine Dimers Is Associated with SLFN11 Downregulation and Can Be Reversed through Inhibition of ATR.
Autor: Mao S; Early Oncology R&D, AstraZeneca, Gaithersburg, Maryland. shenlan.mao@astrazeneca.com john.harper@astrazeneca.com., Chaerkady R; Antibody Discovery & Protein Engineering, AstraZeneca, Gaithersburg, Maryland., Yu W; Bioinformatics, AstraZeneca, Gaithersburg, Maryland., D'Angelo G; Biometrics, AstraZeneca, Gaithersburg, Maryland., Garcia A; Antibody Discovery & Protein Engineering, AstraZeneca, Gaithersburg, Maryland., Chen H; Early Oncology R&D, AstraZeneca, Gaithersburg, Maryland., Barrett AM; Early Oncology R&D, AstraZeneca, Gaithersburg, Maryland., Phipps S; Antibody Discovery & Protein Engineering, AstraZeneca, Gaithersburg, Maryland., Fleming R; Antibody Discovery & Protein Engineering, AstraZeneca, Gaithersburg, Maryland., Hess S; Antibody Discovery & Protein Engineering, AstraZeneca, Gaithersburg, Maryland., Koopmann JO; Early Oncology R&D, AstraZeneca, Gaithersburg, Maryland., Dimasi N; Antibody Discovery & Protein Engineering, AstraZeneca, Gaithersburg, Maryland., Wilson S; Antibody Discovery & Protein Engineering, AstraZeneca, Gaithersburg, Maryland., Pugh K; Spirogen, AstraZeneca, London, United Kingdom., Cook K; Early Oncology R&D, AstraZeneca, Gaithersburg, Maryland., Masterson LA; Spirogen, AstraZeneca, London, United Kingdom., Gao C; Antibody Discovery & Protein Engineering, AstraZeneca, Gaithersburg, Maryland., Wu H; Antibody Discovery & Protein Engineering, AstraZeneca, Gaithersburg, Maryland., Herbst R; Early Oncology R&D, AstraZeneca, Gaithersburg, Maryland., Howard PW; Spirogen, AstraZeneca, London, United Kingdom., Tice DA; Early Oncology R&D, AstraZeneca, Gaithersburg, Maryland., Cobbold M; Early Oncology R&D, AstraZeneca, Gaithersburg, Maryland., Harper J; Early Oncology R&D, AstraZeneca, Gaithersburg, Maryland. shenlan.mao@astrazeneca.com john.harper@astrazeneca.com.
Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2021 Mar; Vol. 20 (3), pp. 541-552.
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7
Akademický článek
Synthesis and evaluation of pyrrolobenzodiazepine dimer antibody-drug conjugates with dual β-glucuronide and dipeptide triggers.
Autor: Gregson SJ; Spirogen, QMB Innovation Centre, 42 New Road, London, E1 2AX, United Kingdom. Electronic address: gregsons@medimmune.com., Barrett AM; AstraZeneca, One MedImmune Way, Gaithersburg, MD, 20878, USA. Electronic address: barretta@astrazeneca.com., Patel NV; Spirogen, QMB Innovation Centre, 42 New Road, London, E1 2AX, United Kingdom. Electronic address: patelnek@medimmune.com., Kang GD; Spirogen, QMB Innovation Centre, 42 New Road, London, E1 2AX, United Kingdom., Schiavone D; AstraZeneca, Granta Park, Cambridge, CB21 6GH, United Kingdom., Sult E; AstraZeneca, One MedImmune Way, Gaithersburg, MD, 20878, USA., Barry CS; Spirogen, QMB Innovation Centre, 42 New Road, London, E1 2AX, United Kingdom., Vijayakrishnan B; Spirogen, QMB Innovation Centre, 42 New Road, London, E1 2AX, United Kingdom., Adams LR; Spirogen, QMB Innovation Centre, 42 New Road, London, E1 2AX, United Kingdom., Masterson LA; Spirogen, QMB Innovation Centre, 42 New Road, London, E1 2AX, United Kingdom., D'Hooge F; Spirogen, QMB Innovation Centre, 42 New Road, London, E1 2AX, United Kingdom., Snaith M; AstraZeneca, Granta Park, Cambridge, CB21 6GH, United Kingdom., Harper J; AstraZeneca, One MedImmune Way, Gaithersburg, MD, 20878, USA., Hartley JA; Spirogen, QMB Innovation Centre, 42 New Road, London, E1 2AX, United Kingdom., Howard PW; Spirogen, QMB Innovation Centre, 42 New Road, London, E1 2AX, United Kingdom.
Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2019 Oct 01; Vol. 179, pp. 591-607. Date of Electronic Publication: 2019 Jun 18.
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8
Akademický článek
Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine.
Autor: Hartley JA; Cancer Research UK Drug DNA Interactions Research Group, UCL Cancer Institute, 72 Huntley Street, London, WC1E 6BT, UK. john.hartley@ucl.ac.uk.; Spirogen Ltd, QMB Innovation Centre, 42 New Road, London, E1 2AX, UK. john.hartley@ucl.ac.uk., Flynn MJ; Cancer Research UK Drug DNA Interactions Research Group, UCL Cancer Institute, 72 Huntley Street, London, WC1E 6BT, UK., Bingham JP; Cancer Research UK Drug DNA Interactions Research Group, UCL Cancer Institute, 72 Huntley Street, London, WC1E 6BT, UK., Corbett S; Cancer Research UK Drug DNA Interactions Research Group, UCL Cancer Institute, 72 Huntley Street, London, WC1E 6BT, UK.; Spirogen Ltd, QMB Innovation Centre, 42 New Road, London, E1 2AX, UK., Reinert H; Cancer Research UK Drug DNA Interactions Research Group, UCL Cancer Institute, 72 Huntley Street, London, WC1E 6BT, UK., Tiberghien A; Spirogen Ltd, QMB Innovation Centre, 42 New Road, London, E1 2AX, UK., Masterson LA; Spirogen Ltd, QMB Innovation Centre, 42 New Road, London, E1 2AX, UK., Antonow D; Spirogen Ltd, QMB Innovation Centre, 42 New Road, London, E1 2AX, UK., Adams L; Spirogen Ltd, QMB Innovation Centre, 42 New Road, London, E1 2AX, UK., Chowdhury S; Spirogen Ltd, QMB Innovation Centre, 42 New Road, London, E1 2AX, UK., Williams DG; Spirogen Ltd, QMB Innovation Centre, 42 New Road, London, E1 2AX, UK., Mao S; MedImmune, One MedImmune Way, Gaithersburg, MD, 20878, USA., Harper J; MedImmune, One MedImmune Way, Gaithersburg, MD, 20878, USA., Havenith CEG; ADC Therapeutics (UK) Limited, QMB Innovation Centre, 42 New Road, London, E1 2AX, UK., Zammarchi F; ADC Therapeutics (UK) Limited, QMB Innovation Centre, 42 New Road, London, E1 2AX, UK., Chivers S; ADC Therapeutics (UK) Limited, QMB Innovation Centre, 42 New Road, London, E1 2AX, UK., van Berkel PH; ADC Therapeutics (UK) Limited, QMB Innovation Centre, 42 New Road, London, E1 2AX, UK., Howard PW; Spirogen Ltd, QMB Innovation Centre, 42 New Road, London, E1 2AX, UK.
Publikováno v: Scientific reports [Sci Rep] 2018 Jul 11; Vol. 8 (1), pp. 10479. Date of Electronic Publication: 2018 Jul 11.
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9
Akademický článek
Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity.
Autor: Wei B; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Gunzner-Toste J; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Yao H; WuXi AppTec , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China., Wang T; WuXi AppTec , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China., Wang J; WuXi AppTec , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China., Xu Z; WuXi AppTec , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China., Chen J; WuXi AppTec , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China., Wai J; WuXi AppTec , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China., Nonomiya J; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Tsai SP; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Chuh J; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Kozak KR; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Liu Y; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Yu SF; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Lau J; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Li G; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Phillips GD; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Leipold D; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Kamath A; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Su D; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Xu K; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Eigenbrot C; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Steinbacher S; Proteros Biostructures GmbH , Bunsenstrasse 7a, D-82152 Martinsried, Germany., Ohri R; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Raab H; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Staben LR; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Zhao G; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Flygare JA; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Pillow TH; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Verma V; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Masterson LA; Spirogen, QMB Innovation Centre, 42 New Road, London E1 2AX, United Kingdom., Howard PW; Spirogen, QMB Innovation Centre, 42 New Road, London E1 2AX, United Kingdom., Safina B; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Feb 08; Vol. 61 (3), pp. 989-1000. Date of Electronic Publication: 2017 Dec 21.
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10
Akademický článek
Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers.
Autor: Gregson SJ; Spirogen , QMB Innovation Centre, 42 New Road, London E1 2AX, United Kingdom., Masterson LA; Spirogen , QMB Innovation Centre, 42 New Road, London E1 2AX, United Kingdom., Wei B; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Pillow TH; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Spencer SD; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Kang GD; Spirogen , QMB Innovation Centre, 42 New Road, London E1 2AX, United Kingdom., Yu SF; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Raab H; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Lau J; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Li G; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Lewis Phillips GD; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Gunzner-Toste J; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Safina BS; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Ohri R; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Darwish M; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Kozak KR; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Dela Cruz-Chuh J; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Polson A; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Flygare JA; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Howard PW; Spirogen , QMB Innovation Centre, 42 New Road, London E1 2AX, United Kingdom.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2017 Dec 14; Vol. 60 (23), pp. 9490-9507. Date of Electronic Publication: 2017 Nov 16.
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